A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

scientific article published on 23 May 2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2018NatCo...9.2036V
P6179Dimensions Publication ID1104045470
P356DOI10.1038/S41467-018-04376-5
P932PMC publication ID5964249
P698PubMed publication ID29789522

P50authorRoosmarijn VandenbrouckeQ27925463
Marco PrinzQ30055422
Marta Joana Costa JordãoQ91048871
Charlotte ScottQ57340218
Anna SchroederQ59662660
Joris de WitQ61138380
Ori StaszewskiQ61799179
Geert van LooQ81204658
Mohamed LamkanfiQ86768467
Steffen JungQ39989609
Martin GuilliamsQ48148352
Esther HosteQ49057750
P2093author name stringSaskia Lippens
Claude Libert
Patrick Callaerts
Lieselotte Vande Walle
Ki-Wook Kim
Zsuzsanna Callaerts-Vegh
Delphine Demeestere
Nora Hagemeyer
Conor Mc Guire
Mozes Sze
Griet Van Imschoot
Amanda Gonçalves
Arne Martens
Carmen Daems
Hanna-Kaisa Vikkula
Peter Wieghofer
Sofie Voet
P2860cites workNLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceQ24604235
Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationQ24614960
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient miceQ24616207
Origin, fate and dynamics of macrophages at central nervous system interfacesQ27315656
Microglia contact induces synapse formation in developing somatosensory cortex.Q27332174
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.Q27340206
Cryopyrin activates the inflammasome in response to toxins and ATPQ28291313
A20 deficiency causes spontaneous neuroinflammation in miceQ28392084
STAR: ultrafast universal RNA-seq alignerQ29615052
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxietyQ29615160
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionQ29615589
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitisQ30519470
Neurotoxic reactive astrocytes are induced by activated microgliaQ33602850
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.Q33662701
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitisQ33979901
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritisQ34020795
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathwaysQ34035175
Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.Q34059225
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.Q34123789
featureCounts: an efficient general purpose program for assigning sequence reads to genomic featuresQ34384848
Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitisQ34401745
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Q34441257
Innate immunity: the missing link in neuroprotection and neurodegeneration?Q34627260
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisQ34646876
Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpointsQ35657580
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission.Q35708750
Creating reference gene annotation for the mouse C57BL6/J genome assemblyQ36149441
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cellsQ36534480
NLRP3 Inflammasome and MS/EAE.Q36566053
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory diseaseQ36649404
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.Q50982264
Applications of the Morris water maze in the study of learning and memoryQ56442716
Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune EncephalomyelitisQ61709597
Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytesQ86060723
NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responsesQ36670359
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synucleinQ37213687
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activationQ37515104
The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis.Q37635764
A20 in inflammation and autoimmunityQ38163677
Inflammasomes in the CNS.Q38176535
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric diseaseQ38203104
Mechanisms and functions of inflammasomesQ38214128
Microglia Plasticity During Health and Disease: An Immunological Perspective.Q38598038
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems.Q38598043
Central nervous system myeloid cells as drug targets: current status and translational challengesQ38658658
A Unique Microglia Type Associated with Restricting Development of Alzheimer's DiseaseQ38672340
The role of peripheral immune cells in the CNS in steady state and diseaseQ39090618
Ontogeny and homeostasis of CNS myeloid cellsQ39190125
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammationQ39342489
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturationQ39604232
A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouseQ42584977
Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neuronsQ42719160
Reply to Verbeeck and Kearsley: Addressing the challenges of including lianas in global vegetation models.Q43089921
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokinQ45021806
A new fate mapping system reveals context-dependent random or clonal expansion of microgliaQ46046152
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative DiseasesQ47568641
LPA5 receptor plays a role in pain sensitivity, emotional exploration and reversal learningQ47952984
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.Q48137631
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritisQ49050925
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammasome complexQ412405
microgliaQ1622829
neuronitisQ17157137
P304page(s)2036
P577publication date2018-05-23
P1433published inNature CommunicationsQ573880
P1476titleA20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
P478volume9

Reverse relations

cites work (P2860)
Q90798967A20 attenuates hypoxia-induced pulmonary arterial hypertension by inhibiting NF-κB activation and pulmonary artery smooth muscle cell proliferation
Q92000333A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain
Q64259754Cellular Specificity of NF-κB Function in the Nervous System
Q91576425Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity
Q99711187Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
Q89805363Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia
Q97692714Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases
Q64901156Inflammasomes in neuroinflammatory and neurodegenerative diseases.
Q64957718Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
Q92774897MicroRNA-127 Promotes Anti-microbial Host Defense through Restricting A20-Mediated De-ubiquitination of STAT3
Q92778157MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation
Q91711842Nuclear Factor κB (NF-κB)-Mediated Inflammation in Multiple Sclerosis
Q91972897Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease
Q94545415TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
Q64273567The Astrocytic cAMP Pathway in Health and Disease
Q57817925The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Q92358046The NLRP3 inflammasome: a new player in neurological diseases
Q60914917VSIG4 mediates transcriptional inhibition of and β in macrophages
Q92188816Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination
Q64063344miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice

Search more.