Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine.

scientific article published in February 2018

Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.HELIYON.2018.E00521
P932PMC publication ID5857623
P698PubMed publication ID29560444

P50authorDaisuke KadowakiQ50600194
Yuki KondoQ59705484
Yoichi IshitsukaQ73209250
P2093author name stringTetsumi Irie
Mitsuru Irikura
Minako Nagatome
Yusuke Saishyo
P2860cites workPeroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicityQ46635865
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.Q46775419
Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis modelsQ46814306
Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxicationQ48279965
Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in MiceQ48857460
beta-Amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration.Q50536776
Suppression of Mitochondrial Succinate Dehydrogenase, a Primary Target of β‐Amyloid, and Its Derivative Racemized at Ser ResidueQ50756222
The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.Q50760156
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.Q54343153
Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity.Q54379972
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injuryQ79967745
Ethyl pyruvate: a novel anti-inflammatory agentQ80054477
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injuryQ80077527
Ethyl pyruvate: a novel treatment for sepsisQ80149302
Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horsesQ83861637
Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicityQ84396286
Sterile inflammation in acute liver injury: myth or mystery?Q26799490
Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuriesQ28068263
Targeting Pink1-Parkin-mediated mitophagy for treating liver injuryQ28082937
Acetaminophen-induced hepatotoxicityQ28185453
Mechanisms of hepatotoxicityQ28216749
Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in MiceQ28392505
Paracetamol poisonings in the Czech and Slovak Republic and N-acetylcysteine treatment. Data analysisQ30886845
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationQ34156078
Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.Q34567487
Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicityQ34580637
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicityQ34630779
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicityQ35161427
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicityQ35718640
Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdoseQ36093484
Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting ListQ36437169
Pyruvate is an endogenous anti-inflammatory and anti-oxidant moleculeQ36461570
Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Q36718265
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAsQ36930476
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosisQ37004604
The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compoundsQ37709590
Pyruvate antioxidant roles in human fibroblasts and embryonic stem cellsQ38714417
HMGB1/RAGE axis promotes autophagy and protects keratinocytes from ultraviolet radiation-induced cell deathQ38724486
Trends in rates of acetaminophen-related adverse events in the United StatesQ38946697
Role of the inflammasome in acetaminophen-induced liver injury and acute liver failureQ39027620
Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation.Q39203445
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosisQ40559497
Comparative Effects of Phosphoenolpyruvate, a Glycolytic Intermediate, as an Organ Preservation Agent with Glucose and N-Acetylcysteine against Organ Damage during Cold Storage of Mouse Liver and KidneyQ41875280
Patients with acute liver failure listed for superurgent liver transplantation in France: reevaluation of the Clichy-Villejuif criteriaQ41956652
N-acetylcysteine amide, a promising antidote for acetaminophen toxicityQ42700054
Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cellsQ44625379
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.Q44693987
Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosisQ45243969
Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicityQ45302974
A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypassQ46331601
Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System RegulationQ46477020
P433issue2
P304page(s)e00521
P577publication date2018-02-01
P1433published inHeliyonQ27727019
P1476titleEthyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine
P478volume4