SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin.

scientific article published in May 2018

SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.02408-17
P932PMC publication ID5930302
P698PubMed publication ID29717016

P2093author name stringLi Sun
Shi Jiao
Zhaocai Zhou
Jian-Hua Wang
Xia Jin
Wei-Wei Sun
P2860cites workRecruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencingQ24294385
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.Q24296713
Coupling of the nucleus and cytoplasm: role of the LINC complexQ24299991
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteinsQ24336621
NMR structure of a biologically active peptide containing the RNA-binding domain of human immunodeficiency virus type 1 TatQ24564152
A diverse range of gene products are effectors of the type I interferon antiviral responseQ24626018
Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureQ26999858
Structural insights into SUN-KASH complexes across the nuclear envelopeQ27671858
High-resolution profiling of histone methylations in the human genomeQ27860906
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
Sun2 is a novel mammalian inner nuclear membrane proteinQ28256268
Epigenetic regulation of HIV-1 latency by cytosine methylationQ28475636
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylationQ28477616
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in miceQ28509255
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patientsQ28538015
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelopeQ28587115
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
Yeast genetic analysis reveals the involvement of chromatin reassembly factors in repressing HIV-1 basal transcriptionQ33400343
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and diseaseQ33551452
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell cloneQ33847737
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.Q33859070
Subcellular localization of SUN2 is regulated by lamin A and Rab5Q33927043
Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.Q34057748
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latencyQ34090863
A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexesQ34139815
Capsid is a dominant determinant of retrovirus infectivity in nondividing cellsQ34152408
Current views on HIV-1 latency, persistence, and cure.Q38973362
Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylationQ39173734
Reactivation of latent HIV-1 by inhibition of BRD4.Q39264882
Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G.Q39590547
Distance between homologous chromosomes results from chromosome positioning constraints.Q39630547
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latencyQ39933477
SUN2 Silencing Impairs CD4 T Cell Proliferation and Alters Sensitivity to HIV-1 Infection Independently of Cyclophilin A.Q40375929
Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitinationQ40502162
Regulation of an inducible promoter by an HP1beta-HP1gamma switchQ41767088
Mechanisms of HIV Transcriptional Regulation and Their Contribution to LatencyQ41769072
Chromatin reassembly factors are involved in transcriptional interference promoting HIV latencyQ42059823
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latencyQ42100247
Gene expression, chromosome position and lamin A/C mutationsQ42854627
The inner-nuclear-envelope protein emerin regulates HIV-1 infectivityQ43842116
Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.Q51616068
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.Q52633974
IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production.Q53912559
Inner nuclear membrane proteins: impact on human diseaseQ34252203
Control of RNA polymerase II activity by dedicated CTD kinases and phosphatasesQ34386447
Epigenetic heterogeneity in HIV-1 latency establishmentQ34877762
Gene silencing in HIV-1 latency by polycomb repressive groupQ34980577
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.Q35192959
Histone deacetylase inhibitors in clinical studies as templates for new anticancer agentsQ35214924
Eradicating HIV-1 infection: seeking to clear a persistent pathogenQ35252186
T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisQ35543827
Epigenetic modulations in activated cells early after HIV-1 infection and their possible functional consequences.Q35601948
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.Q35632054
Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin proteinQ35634356
The multifactorial nature of HIV-1 latencyQ35935335
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage responseQ36303518
Molecular mechanisms of HIV latencyQ36515063
The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.Q36673184
SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV.Q36736438
Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV ReplicationQ36850405
The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcriptionQ37023583
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cellsQ37039142
Laminopathies disrupt epigenomic developmental programs and cell fateQ37081776
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cellsQ37148527
Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection.Q37207653
Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4+ T Cells.Q37512889
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirsQ37615893
Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat.Q37638282
Mechanisms of HIV latency: an emerging picture of complexityQ37738147
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individualsQ37771138
Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cellsQ37802560
Stochastic genome-nuclear lamina interactions: modulating roles of Lamin A and BAF.Q38203362
Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathiesQ38284300
HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cellsQ38298509
A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alphaQ38800544
Loss of lamin A function increases chromatin dynamics in the nuclear interior.Q38841598
P433issue3
P577publication date2018-05-01
P1433published inmBioQ15817061
P1476titleSUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin.
P478volume9

Reverse relations

cites work (P2860)
Q64120808Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter
Q90244949PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat (LTR)
Q59359386Scaffold attachment factor B suppresses HIV-1 infection of CD4 T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat
Q92058253Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

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