Molecular mechanisms of HIV latency

scientific article published on 5 January 2016

Molecular mechanisms of HIV latency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI80565
P932PMC publication ID4731164
P698PubMed publication ID26731470

P2093author name stringB Matija Peterlin
Koh Fujinaga
Daniele C Cary
P2860cites workIsolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Q22242256
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.Q24537283
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase IIQ24605935
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Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureQ26999858
A highly purified RNA polymerase II elongation control systemQ28216031
Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophagesQ28253165
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNAQ28263974
Pneumocystis pneumonia--Los AngelesQ28264042
Exosomes derived from HIV-1-infected cells contain trans-activation response element RNAQ28290390
Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor siteQ71584691
Host factors regulating post-integration latency of HIVQ81627002
The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cellsQ28306379
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitroQ28379179
Epigenetic regulation of HIV-1 latency by cytosine methylationQ28475636
Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesQ28487524
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosingQ28537694
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene ExpressionQ28546918
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response elementQ28646726
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell linesQ28647556
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitroQ29614788
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Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
An inducible transcription factor activates expression of human immunodeficiency virus in T cellsQ29618434
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HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.Q33262230
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Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factorsQ33367106
Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeatQ33602605
Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator TatQ33728518
Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.Q34057748
Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell lineQ34070377
HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostatQ34106191
Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1Q34132738
Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesisQ34257238
Human immunodeficiency virus long terminal repeat responds to T-cell activation signalsQ34350307
Transcriptional interference antagonizes proviral gene expression to promote HIV latencyQ34443670
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeatQ34563887
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studiesQ34607763
Molecular cloning of lymphadenopathy-associated virusQ34707015
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.Q34985945
Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiationQ35071358
The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiationQ35072999
Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processingQ35097083
Visualization of positive transcription elongation factor b (P-TEFb) activation in living cellsQ35121356
Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein productsQ35157534
Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.Q35168379
Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcriptsQ35202038
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 proteinQ35211232
Reactivation of latent HIV-1 by new semi-synthetic ingenol estersQ35252396
Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.Q35720063
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Q35826285
CDK11 in TREX/THOC Regulates HIV mRNA 3' End ProcessingQ36289312
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoproteinQ36332978
Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing.Q36368754
MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes.Q36404157
HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen.Q36534267
Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivoQ37031659
Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signalingQ37041173
Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivoQ37348552
A point mutation in the HIV-1 Tat responsive element is associated with postintegration latencyQ37518835
Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.Q37683410
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.Q37695001
Efficient delivery of lentiviral vectors into resting human CD4 T cellsQ37735112
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcriptionQ38043848
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyondQ38064281
Reactivation of latent HIV: do all roads go through P-TEFb?Q38177273
Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirusQ38905078
Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcriptionQ39173861
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.Q39723092
Effects of prostratin on T-cell activation and human immunodeficiency virus latencyQ39753161
CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicingQ39764495
Detection, characterization and regulation of antisense transcripts in HIV-1.Q40073362
The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cellsQ40588850
Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitroQ40622068
Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genesQ40886843
P-TEFb as a target to reactivate latent HIV: two Brds are now in handQ41641914
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.Q41880147
Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activationQ41885967
Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency.Q42968418
Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough.Q43226911
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.Q43730164
Recombination: Multiply infected spleen cells in HIV patientsQ43923409
Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complexQ45405018
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).Q45838520
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).Q48381924
Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.Q50667759
Purification of P-TEFb, a transcription factor required for the transition into productive elongation.Q52539193
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)448-454
P577publication date2016-01-05
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMolecular mechanisms of HIV latency
P478volume126

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