A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

scientific article

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(00)80939-3
P3181OpenCitations bibliographic resource ID126446
P698PubMed publication ID9491887

P50authorFang ZhouziQ633818
P2093author name stringP Wei
K A Jones
W H Fischer
S M Fang
M E Garber
P2860cites workMajor determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAsQ45188961
Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.Q46000120
Alternative mechanisms of CAK assembly require an assembly factor or an activating kinaseQ46760600
Purification of P-TEFb, a transcription factor required for the transition into productive elongation.Q52539193
Mechanism and regulation of transcriptional elongation and termination by RNA polymerase IIQ63384164
Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complexQ24568316
Novel mechanism and factor for regulation by HIV-1 TatQ24568366
The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzymeQ24646774
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactorQ24676286
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpinQ27730785
A kinase-cyclin pair in the RNA polymerase II holoenzyme.Q27930481
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complexQ27932742
Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I.Q27934205
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinaseQ28247022
A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancerQ28271385
Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 TatQ28292698
CDK-independent activation of estrogen receptor by cyclin D1Q28304020
Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexesQ28304889
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitroQ28379179
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell linesQ28647556
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitroQ29614788
Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinaseQ29614789
PEST sequences and regulation by proteolysisQ29616394
Control of RNA initiation and elongation at the HIV-1 promoterQ29620157
Stress and developmental regulation of the yeast C-type cyclin Ume3p (Srb11p/Ssn8p).Q33887194
Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryosQ34250244
Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpinQ34631467
Synergism between Tat and VP16 in trans-activation of HIV-1 LTR.Q38313551
The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequenceQ38324797
Control of formation of two distinct classes of RNA polymerase II elongation complexes.Q38329037
Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complexQ38342881
Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1.Q40041905
Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR.Q40045425
TAR loop-dependent human immunodeficiency virus trans activation requires factors encoded on human chromosome 12.Q40046655
RNA-protein interactions. Diverse modes of recognitionQ40401623
News on initiation and elongation of transcription by RNA polymerase II.Q40475471
A weak interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2B" proteinQ40531081
RNA recognition by the human immunodeficiency virus Tat and Rev proteinsQ40767437
Does HIV-1 Tat induce a change in viral initiation rights?Q40905875
The U2B'' RNP motif as a site of protein-protein interaction.Q41230779
Taking a new TAK on tat transactivationQ41614227
Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.Q43447901
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic regionQ43480910
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)451-62
P577publication date1998-02-20
P1433published inCellQ655814
P1476titleA novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
P478volume92

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Q37974218HIV latency
Q40361663HIV latency: present knowledge, future directions
Q78128370HIV recent advances in AIDS research: genetics, molecular biology and immunology
Q26995784HIV restriction in quiescent CD4⁺ T cells
Q33292300HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1.
Q40352274HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells
Q39134277HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations.
Q34896128HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription
Q39703646HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
Q37518169HIV-1 Tat directly binds to NFkappaB enhancer sequence: role in viral and cellular gene expression
Q24564896HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
Q40016960HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells
Q44061963HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter
Q41675687HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.
Q33940354HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA.
Q30436450HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum
Q28215081HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110
Q40727461HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription
Q42767857HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear
Q33711447HIV-1 Tat: coping with negative elongation factors
Q47555826HIV-1 Vif's capacity to manipulate the cell cycle is species-specific
Q47964324HIV-1 auxiliary proteins: making connections in a dying cell
Q21245215HIV-1 gene expression: lessons from provirus and non-integrated DNA
Q38204866HIV-1 latency: an update of molecular mechanisms and therapeutic strategies
Q35166833HIV-1 pathogenesis
Q37607912HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes
Q38273477HIV-1 replication and latency are regulated by translational control of cyclin T1
Q22007982HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
Q77891434HIV-1 transcription: activation mediated by acetylation of Tat
Q51981129HIV-1 transgenic rat CD4+ T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation.
Q36407266HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.
Q36901782HMGA1 directly interacts with TAR to modulate basal and Tat-dependent HIV transcription
Q27469600Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding
Q45395775Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells
Q35058535Hide, shield and strike back: how HIV-infected cells avoid immune eradication
Q34291018High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier
Q38808207High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis.
Q39446082Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism
Q38357741Histone deacetylase 6 in health and disease
Q37086989Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9.
Q59357225Host and Viral Factors Influencing Interplay between the Macrophage and HIV-1
Q33455551Host cell factors in HIV replication: meta-analysis of genome-wide studies
Q36390969Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication
Q28243562Hsp90: a chaperone for HIV-1
Q36363829Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells
Q24307731Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation
Q33850701Human GLI-2 is a tat activation response element-independent Tat cofactor
Q40967217Human T-cell leukemia virus type 1 can infect a wide variety of cells in mice
Q39629705Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection
Q89522955Human Tat-specific factor 1 binds the HIV-1 genome and selectively transports HIV-1 RNAs
Q33815080Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate
Q33825196Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS.
Q34545610Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.
Q42829649Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity
Q43193366Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
Q36330062Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication
Q33863026Human immunodeficiency virus Tat associates with a specific set of cellular RNAs
Q33809273Human immunodeficiency virus and AIDS: insights from animal lentiviruses
Q33541775Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy.
Q24564662Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression
Q40004324Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
Q39612144Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process
Q45723766Human immunodeficiency virus type 1 envelope-mediated neuropathogenesis: targeted gene delivery by a Sindbis virus expression vector
Q41039158Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages.
Q39685140Human immunodeficiency virus type 1 nucleocapsid protein nuclear localization mediates early viral mRNA expression
Q40679108Human immunodeficiency virus type 1 subtype C exhibits higher transactivation activity of Tat than subtypes B and E.
Q39595632Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR
Q35906138Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.
Q24310867Human mediator subunit MED26 functions as a docking site for transcription elongation factors
Q35168345Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.
Q56795003Identification of Limiting Steps for Efficient Trans-activation of HIV-1 Promoter by Tat inSaccharomyces cerevisiae
Q39611074Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation
Q28247078Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat
Q24317025Identification of multiple cyclin subunits of human P-TEFb
Q41457054Identification of novel inhibitors against Cyclin Dependent Kinase 9/Cyclin T1 complex as: Anti cancer agent
Q34527341Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction
Q37034627Identification of potential drug targets using genomics and proteomics: a systems approach
Q38714324Imaging HIV-1 Genomic DNA from Entry through Productive Infection
Q26782046Impact of Chromatin on HIV Replication
Q36148507Impact of Tat Genetic Variation on HIV-1 Disease
Q40541599Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway
Q36805433Improving HIV proteome annotation: new features of BioAfrica HIV Proteomics Resource
Q52808328In cell mutational interference mapping experiment (in cell MIME) identifies the 5' polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging.
Q28211352In vitro evidence for a long range pseudoknot in the 5'-untranslated and matrix coding regions of HIV-1 genomic RNA
Q38291138In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes
Q39324883In vitro susceptibility to infection with SIVcpz and HIV-1 is lower in chimpanzee than in human peripheral blood mononuclear cells
Q35066359In vivo SELEX of single-stranded domains in the HIV-1 leader RNA.
Q30439541Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula
Q42554535Indirubin 3'-monoxime, from a Chinese traditional herbal formula, suppresses viremia in humanized mice infected with multidrug-resistant HIV
Q40414692Induction of OGG1 gene expression by HIV-1 Tat.
Q33849629Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines
Q21245103Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content
Q35073696Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1.
Q35192970Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.
Q77219939Inhibition of HIV-1 replication by anti-trans-activation responsive polyamide nucleotide analog
Q53909022Inhibition of HIV-1 replication by cell-penetrating peptides binding Rev.
Q36850296Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant.
Q45049610Inhibition of HIV-1 virus replication using small soluble Tat peptides
Q24298519Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
Q36915824Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors
Q31115718Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies
Q28478188Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
Q35036496Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y.
Q36954414Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).
Q39470193Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells
Q28343602Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species
Q28344365Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors
Q33780297Inhibition of human immunodeficiency virus type-1 by cdk inhibitors
Q39139534Inhibitory function of adapter-related protein complex 2 alpha 1 subunit in the process of nuclear translocation of human immunodeficiency virus type 1 genome
Q37354566Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
Q39676027Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes
Q24548261Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome
Q33890579Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding
Q39601983Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells
Q73408185Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners
Q39581386Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein
Q38358056Interaction of the porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain-containing protein
Q39589026Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1.
Q34987620Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T
Q45316630Interactions of Tat with host cellular proteins
Q79745144Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysis
Q28217472Interplay between cdk9 and NF-kappaB factors determines the level of HIV-1 gene transcription in astrocytic cells
Q39921503Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene
Q33853960Invisible RNA state dynamically couples distant motifs
Q34171674Involvement of cyclin K posttranscriptional regulation in the formation of Artemia diapause cysts
Q36143645Iron chelators ICL670 and 311 inhibit HIV-1 transcription
Q36005484Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release
Q47844049Isolation and characterization of the human cyclin T1 promoter
Q40852764Isolation of Cognate Cellular and Viral Ribonucleoprotein Complexes of HIV-1 RNA Applicable to Proteomic Discovery and Molecular Investigations.
Q35131684Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection
Q28376959Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency
Q89673835JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes
Q33799971Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication
Q84654190Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion
Q24646322LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
Q25255905Latency: the hidden HIV-1 challenge
Q47098902Latent HIV-1 TAR Regulates 7SK-responsive P-TEFb Target Genes and Targets Cellular Immune Responses in the Absence of Tat.
Q36155046Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.
Q34452109Lentivirus and foamy virus vectors: novel gene therapy tools
Q34754954Lentiviruses as gene transfer agents for delivery to non-dividing cells
Q35012861Linking cyclins to transcriptional control.
Q27651054Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex
Q37010047Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
Q34075254Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription
Q39804456Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts
Q38091888Lost in transcription: molecular mechanisms that control HIV latency
Q37583411Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA
Q36699534Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.
Q24679741MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner
Q36274198MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding
Q35597624MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.
Q41927990Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription
Q38212042Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.
Q40118214Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.
Q37822089Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise
Q28140555Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style
Q34987465Matrix mediates the functional link between human immunodeficiency virus type 1 RNA nuclear export elements and the assembly competency of Gag in murine cells.
Q40670620Matrix-induced inhibition of membrane binding contributes to human immunodeficiency virus type 1 particle assembly defects in murine cells.
Q33680820Mechanism and regulation of transcriptional elongation by RNA polymerase II.
Q41769072Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency
Q33815611Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse
Q24558697Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression
Q34730602Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
Q21146658Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection
Q61800035Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure
Q24808657Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
Q55405435Molecular Mechanisms of Injury in HIV-Associated Nephropathy.
Q42836979Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication
Q38310688Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV-1.
Q54441914Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5.
Q40374329Molecular dynamics and MM/GBSA-integrated protocol probing the correlation between biological activities and binding free energies of HIV-1 TAR RNA inhibitors.
Q28544421Molecular dynamics simulation and experimental verification of the interaction between cyclin T1 and HIV-1 Tat proteins
Q36515063Molecular mechanisms of HIV latency
Q33864438Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
Q36278085Molecular mechanisms of HIV-1 proviral latency
Q36916993Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration
Q33837992Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly
Q33743566Multifaceted activities of the HIV-1 transactivator of transcription, Tat.
Q47555946Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature
Q34033118Multiple biological roles associated with the repeat (R) region of the HIV-1 RNA genome
Q33603453Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
Q35914370Multiple restrictions of human immunodeficiency virus type 1 in feline cells
Q47822116Mutation of the major 5' splice site renders a CMV-driven HIV-1 proviral clone Tat-dependent: connections between transcription and splicing.
Q39094752Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA
Q35868299Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression
Q42811398Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter
Q30977476NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases
Q30909558NMR characterization of a kissing complex formed between the TAR RNA element of HIV-1 and a DNA aptamer
Q33602605Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat
Q39323907Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression
Q35749130Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline
Q21198772New insights into HIV-1-primary skin disorders
Q34919381New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
Q35122702New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a cercopithecus monkey virus clade
Q42239136New, extended hairpin form of the TAR-2 RNA domain points to the structural polymorphism at the 5' end of the HIV-2 leader RNA.
Q49455798Non-Coding RNAs As Transcriptional Regulators In Eukaryotes
Q49236374Non-coding RNAs and retroviruses.
Q35772862Noncoding RNA localisation mechanisms in chromatin regulation
Q30885539Novel bovine lentiviral vectors based on Jembrana disease virus
Q37547409Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication
Q35635000Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells
Q28177130Nuclear protein phosphatase-1 regulates HIV-1 transcription
Q34101377Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
Q37866370Nuclear remodelling during viral infections
Q25255186Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
Q33178132Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA.
Q39308951Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging
Q39685303Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression
Q39135199Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6.
Q89782162P-TEFb as A Promising Therapeutic Target
Q26741360P-TEFb goes viral
Q38896947P-TEFb goes viral.
Q29620167P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
Q37356131P-TEFb- the final frontier
Q40272529PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription
Q36174095PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Q34650866Pathogenesis and treatment of HIV infection: the cellular, the immune system and the neuroendocrine systems perspective
Q33649755Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems
Q34343774Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins
Q46675052Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
Q28487524Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes
Q35805406Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression
Q24806541Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
Q24537588Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation
Q31072762Physical and functional interaction of HIV-1 Tat with E2F-4, a transcriptional regulator of mammalian cell cycle
Q28143919Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation
Q28114798Physical interaction between pRb and cdk9/cyclinT2 complex
Q34973763Polo-like kinase 1 inhibits the activity of positive transcription elongation factor of RNA Pol II b (P-TEFb).
Q40501267Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex
Q33708590Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents
Q31807459Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
Q39682296Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Q35076669Postentry restriction of Mason-Pfizer monkey virus in mouse cells
Q40073989Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101.
Q30879123Potent inhibition of HIV-1 replication by a Tat mutant
Q33814620Potent inhibition of human immunodeficiency virus type 1 (HIV-1) gene expression and virus production by an HIV-2 tat activation-response RNA decoy
Q36821394Premature termination of transcription by RNAP II: the beginning of the end.
Q35980829Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression
Q73182068Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells
Q39704599Productive replication of Vif-chimeric HIV-1 in feline cells
Q41815313Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters
Q36370241Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
Q35633540Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge
Q34654219Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation.
Q41683241Protein and RNA affinity selection techniques using HIV-1 Tat.
Q37950254Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.
Q24318492Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages
Q38293944Proteomics in the investigation of HIV-1 interactions with host proteins
Q40669160Quantification of the HIV transcriptional activator complex in live cells by image-based protein-protein interaction analysis
Q40140632Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET.
Q41918740Quiescence promotes latent HIV infection and resistance to reactivation from latency with histone deacetylase inhibitors
Q39550188R region sequences in the long terminal repeat of a murine retrovirus specifically increase expression of unspliced RNAs.
Q29540749RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template
Q39685491RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication
Q42027880RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
Q40069803Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui.
Q37305160Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation
Q40108650Real-time visualization of chromatin modification in isolated nuclei.
Q33633451Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
Q33958031Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1.
Q24515333Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.
Q33269333Recruitment and activation of RSK2 by HIV-1 Tat
Q42181127Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency
Q40990135Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.
Q37191856Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription
Q36405698Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription
Q24675942Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein
Q37553804Regulation of CDK9 activity by phosphorylation and dephosphorylation.
Q33769035Regulation of HIV-1 transcription
Q33593821Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression
Q34685118Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6.
Q28289216Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein
Q35826285Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.
Q30350982Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.
Q40335491Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding
Q40236968Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2.
Q34816680Regulation of transcription elongation by phosphorylation
Q36571363Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
Q24552532Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter
Q33940913Renal HIV expression is unaffected by serum LPS levels in an HIV transgenic mouse model of LPS induced kidney injury
Q37099750Replication of equine infectious anemia virus in engineered mouse NIH 3T3 cells
Q34467420Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions
Q34263935Repression of MHC determinants in HIV infection
Q24315665Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter
Q28141637Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription
Q43416969Reservoirs for HIV-1.
Q38610855Resveratrol, sirtuins, and viruses
Q35836276Retroviral mRNA nuclear export elements regulate protein function and virion assembly.
Q37183096Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication
Q37895742Retroviral restriction and dependency factors in primates and carnivores
Q58700378Reversible Human Immunodeficiency Virus Type-1 Latency in Primary Human Monocyte-Derived Macrophages Induced by Sustained M1 Polarization
Q39577905Ribosomal scanning on the 5'-untranslated region of the human immunodeficiency virus RNA genome
Q27486874Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication
Q38430337Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription
Q40945481Role of RNA polymerase II carboxy-terminal domain in coordinating transcription with RNA processing
Q34033128Role of chromatin in HIV-1 transcriptional regulation
Q37631411Role of noncoding RNAs in the regulation of P-TEFb availability and enzymatic activity
Q26996314Roles and functions of HIV-1 Tat protein in the CNS: an overview
Q28286819Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
Q24797263SIRT1 regulates HIV transcription via Tat deacetylation
Q39855918SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1.
Q33990712SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA
Q37472861Sam68 functions in nuclear export and translation of HIV-1 RNA.
Q30651338Screening RNA-binding libraries using Tat-fusion system in mammalian cells
Q51868929Screening strategies to identify host factors associated with the early and late stages of HIV-1 life cycle.
Q40439853Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1.
Q33196801Selection of TAR RNA-binding chameleon peptides by using a retroviral replication system
Q37437860Selective control of gene expression by CDK9 in human cells
Q59354479Semen exosomes promote transcriptional silencing of HIV-1 by disrupting NF-kB/Sp1/Tat circuitry
Q24527316Sequence and transcriptional analyses of the fish retroviruses walleye epidermal hyperplasia virus types 1 and 2: evidence for a gene duplication.
Q30870026Sequence of goat cyclin T1 cDNA, gene organisation and expression analysis
Q34656952Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications
Q34293568Small molecule modulators of cyclin-dependent kinases for cancer therapy
Q33824990Species-specific, postentry barriers to primate immunodeficiency virus infection
Q93010915Specific Activation In Vivo of HIV-1 by a Bromodomain Inhibitor from Monocytic Cells in Humanized Mice under Antiretroviral Therapy
Q36675349Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter
Q35059684Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription
Q39016210Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter
Q24537527Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences
Q35761279Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice
Q37352913Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals
Q37137908Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication
Q42468627Stimulation of Tat-associated kinase-independent transcriptional elongation from the human immunodeficiency virus type-1 long terminal repeat by a cellular enhancer
Q35107931Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions
Q28214807Stimulatory effect of splicing factors on transcriptional elongation
Q33835795Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat.
Q27638717Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Q24632055Structural determinants and mechanism of HIV-1 genome packaging
Q27652984Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV
Q58762403Structural insights into the functional diversity of the CDK-cyclin family
Q90258885Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex
Q27622070Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B
Q77914240Structure and function of HIV-1 and SIV Tat proteins based on carboxy-terminal truncations, chimeric Tat constructs, and NMR modeling
Q22009021Structure and function of the human transcription elongation factor DSIF
Q59070952Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Q96431678Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation
Q59087446Structure of paused transcription complex Pol II-DSIF-NELF
Q34449437Structure-based design of a dimeric RNA-peptide complex
Q40275061Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb
Q37101393Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration
Q38356107Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences
Q39545943Surface plasmon resonance kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification
Q34976301Susceptibility of Mink ( Mustera vision )-Derived Cells to Replication by Human Immunodeficiency Virus Type 1
Q39606789Susceptibility of rat-derived cells to replication by human immunodeficiency virus type 1.
Q39852737Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages
Q34796643Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity
Q35091855Systematic approaches towards the development of host-directed antiviral therapeutics
Q35613792T-cell and neuronal apoptosis in HIV infection: implications for therapeutic intervention
Q35113716T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway
Q34030432TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication
Q41852627TAR-RNA recognition by a novel cyclic aminoglycoside analogue.
Q28188877TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription
Q24600874TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes
Q24304062TRIM5α and Species Tropism of HIV/SIV
Q39724730Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression.
Q40079572Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice
Q35910232Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice
Q54210140Targeting the Latent Reservoir for HIV-1.
Q28214887Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication
Q33957746Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase
Q34161703Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.
Q34033142Tat as a transcriptional activator and a potential therapeutic target for HIV-1.
Q35993736Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccine
Q28144181Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection
Q54254325Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages.
Q90292108Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression
Q28116305Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
Q34156984Tat stimulates cotranscriptional capping of HIV mRNA.
Q78873851Tat's seductive side
Q33455685Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs
Q22003803Tat-SF1 protein associates with RAP30 and human SPT5 proteins
Q28138220Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes
Q33786066Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines
Q45316601Tat-mediated elongation of the HIV-1 transcript
Q44720095Techniques to analyze the HIV-1 Tat and TAR RNA-dependent recruitment and activation of the cyclin T1: CDK9 (P-TEFb) transcription elongation factor.
Q41510614The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes
Q28206012The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
Q27676733The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
Q41862317The Brome mosaic virus subgenomic promoter hairpin is structurally similar to the iron-responsive element and functionally equivalent to the minus-strand core promoter stem-loop C.
Q39777846The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Q40731101The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7
Q24596637The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor
Q38286131The HIV-1 Tat protein has a versatile role in activating viral transcription
Q54977707The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
Q40135003The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.
Q36578522The HIV-1 transgenic rat model of neuroHIV.
Q33893725The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly
Q34382921The MHC class II transactivator: prey and hunter in infectious diseases
Q38043907The Mediator complex and transcription elongation
Q37027897The N-end rule and retroviral infection: no effect on integrase
Q91661378The Per-1 Short Isoform Inhibits de novo HIV-1 Transcription in Resting CD4+ T-cells
Q34654513The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells
Q42117931The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency
Q47824549The Sp1 transcription factor does not directly interact with the HIV-1 Tat protein.
Q42431758The TAR hairpin of human immunodeficiency virus type 1 can be deleted when not required for Tat-mediated activation of transcription
Q35829282The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency
Q35973578The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.
Q42508685The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication
Q35072999The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation
Q39580108The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.
Q28189849The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair
Q28254964The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1
Q24316236The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
Q35188989The carboxyl terminus of phage HK022 Nun includes a novel zinc-binding motif and a tryptophan required for transcription termination.
Q37958430The control of HIV transcription: keeping RNA polymerase II on track
Q36906001The effects of cocaine on HIV transcription
Q39005055The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE.
Q24298498The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression
Q24554329The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription
Q28198162The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat
Q24307870The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription
Q24318776The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription
Q33805882The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA packaging
Q35211232The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
Q34362436The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure
Q21136168The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK
Q34544409The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
Q28143137The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells
Q28595060The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2
Q28251761The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
Q39580918The secondary structure of the R region of a murine leukemia virus is important for stimulation of long terminal repeat-driven gene expression.
Q24323313The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Q36119592The transcriptional cycle of HIV-1 in real-time and live cells.
Q40951736The transcriptional inhibitors, actinomycin D and alpha-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain
Q33700143The transcriptional transactivator Tat selectively regulates viral splicing.
Q30413065The use of Nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells
Q33957637The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway
Q34133579Therapeutic targeting of human immunodeficiency virus type-1 latency: current clinical realities and future scientific possibilities
Q28208318Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences
Q37428613Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription
Q44018972Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1.
Q37194356Transcription elongation control by the 7SK snRNP complex: Releasing the pause.
Q24533266Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages
Q39069527Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication.
Q41853689Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
Q36857070Transcription of HIV: Tat and cellular chromatin
Q40856625Transcriptional activity of positive transcription elongation factor b kinase in vivo requires the C-terminal domain of RNA polymerase II.
Q34030804Transcriptional and posttranscriptional regulation of HIV-1 gene expression
Q24554483Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner
Q33591923Transcriptional control by cell-cycle regulators: a review
Q26999858Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure
Q28275557Transcriptional control: Tat cofactors and transcriptional elongation
Q34443670Transcriptional interference antagonizes proviral gene expression to promote HIV latency
Q44786579Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure
Q35155025Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir
Q40932318Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo
Q34620906Transcriptional regulation of HIV-1 gene expression by p53.
Q35186960Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.
Q24534907Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain
Q37690181Transfection of nerve cells.
Q37398621Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells
Q39685314Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function.
Q39272683Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.
Q34381967Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein
Q40190265Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3' end processing
Q34363290Two alternating structures of the HIV-1 leader RNA
Q77716325Ubiquitous expression of goat cyclin T1 in transgenic mice
Q33930482Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation
Q47695033Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice
Q36202709Use of ATP analogs to inhibit HIV-1 transcription
Q45416488Vaccination of mice with replication-defective human immunodeficiency virus induces cellular and humoral immunity and protects against vaccinia virus-gag challenge
Q83393426Viral RNAs: lessons from the enemy
Q33920746Viral cyclins
Q34104253Viral replication and the coactivators p300 and CBP.
Q35026881Viral-host interactions that control HIV-1 transcriptional elongation
Q24813634Virus-host interactions: new insights from the small RNA world.
Q40786197Visualization of in vivo direct interaction between HIV-1 TAT and human cyclin T1 in specific subcellular compartments by fluorescence resonance energy transfer
Q35121356Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells
Q33785258Walleye retroviruses associated with skin tumors and hyperplasias encode cyclin D homologs.
Q33400343Yeast genetic analysis reveals the involvement of chromatin reassembly factors in repressing HIV-1 basal transcription
Q35034218ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter
Q55360108Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells.
Q38295485c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism
Q28204153c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
Q24629119c-Myc regulates transcriptional pause release
Q30479670iRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hinge
Q35641069p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation
Q33292132p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28.
Q36827396tat Exon 1 exhibits functional diversity during HIV-1 subtype C primary infection.

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