The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.

scientific article published on 4 July 2017

The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2174/1381612823666170704130635
P932PMC publication ID5700838
P698PubMed publication ID28677507

P50authorAndrew P RiceQ55277928
P2093author name stringAndrew P Rice
P2860cites workConserved P-TEFb-interacting domain of BRD4 inhibits HIV transcriptionQ24672881
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactorQ24676286
Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureQ26999858
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 TatQ28247078
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNAQ28263974
Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb ActivationQ28546901
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response elementQ28646726
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell linesQ28647556
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitroQ29614788
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene productQ29615049
miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Q33400321
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell linesQ33786066
Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokinesQ33849629
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitroQ34303073
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeatQ34563887
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.Q34564460
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcriptionQ34896128
T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathwayQ35113716
Reactivation of latent HIV-1 by new semi-synthetic ingenol estersQ35252396
Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.Q35804608
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Q35826285
Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic PatientsQ36076018
PKC phosphorylates HEXIM1 and regulates P-TEFb activity.Q36305691
Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb.Q36601909
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signalingQ36649160
Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivoQ37031659
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase IIQ37103512
Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytesQ37145340
Transcription elongation control by the 7SK snRNP complex: Releasing the pause.Q37194356
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes.Q37429329
RNA polymerase II elongation controlQ37992154
The super elongation complex (SEC) family in transcriptional controlQ38034905
Regulation of HIV-1 latency by chromatin structure and nuclear architecture.Q38235100
Identification of a cyclin subunit required for the function of Drosophila P-TEFbQ38337012
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cellsQ38557763
Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.Q39023875
Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcriptionQ39173861
Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.Q39272683
Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function.Q39685314
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNPQ39703646
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restrictionQ39712159
Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.Q40045693
Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.Q40118214
Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages.Q41039158
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.Q41853689
Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.Q42052356
Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expressionQ42112998
Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.Q43447901
HIV-1 tat trans-activation requires the loop sequence within tar.Q44349676
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongationQ46904254
Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytesQ79254743
Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysisQ79745144
Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophagesQ81579403
P433issue28
P304page(s)4098-4102
P577publication date2017-01-01
P1433published inCurrent Pharmaceutical DesignQ5195068
P1476titleThe HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies
P478volume23

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cites work (P2860)
Q92637590Block-And-Lock Strategies to Cure HIV Infection
Q106453199Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor
Q60927723Focus on Translation Initiation of the HIV-1 mRNAs
Q89685627HIV-associated exosomes promote infection of Kaposi sarcoma-associated herpesvirus via epidermal growth factor receptor
Q90383564Host-HIV-1 Interactome: A Quest for Novel Therapeutic Intervention
Q89555196Human T-Cell Lymphotropic Virus Type 1 Transactivator Tax Exploits the XPB Subunit of TFIIH during Viral Transcription
Q89782162P-TEFb as A Promising Therapeutic Target
Q55285065SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy.
Q54210140Targeting the Latent Reservoir for HIV-1.
Q100503775The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein

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