review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Andrew P Rice | Q55277928 |
P2093 | author name string | Andrew P Rice | |
P2860 | cites work | Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription | Q24672881 |
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor | Q24676286 | ||
Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure | Q26999858 | ||
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat | Q28247078 | ||
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA | Q28263974 | ||
Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation | Q28546901 | ||
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element | Q28646726 | ||
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines | Q28647556 | ||
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro | Q29614788 | ||
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product | Q29615049 | ||
miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1 | Q33400321 | ||
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines | Q33786066 | ||
Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines | Q33849629 | ||
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro | Q34303073 | ||
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat | Q34563887 | ||
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. | Q34564460 | ||
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription | Q34896128 | ||
T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway | Q35113716 | ||
Reactivation of latent HIV-1 by new semi-synthetic ingenol esters | Q35252396 | ||
Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription. | Q35804608 | ||
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes. | Q35826285 | ||
Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients | Q36076018 | ||
PKC phosphorylates HEXIM1 and regulates P-TEFb activity. | Q36305691 | ||
Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb. | Q36601909 | ||
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling | Q36649160 | ||
Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo | Q37031659 | ||
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II | Q37103512 | ||
Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes | Q37145340 | ||
Transcription elongation control by the 7SK snRNP complex: Releasing the pause. | Q37194356 | ||
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes. | Q37429329 | ||
RNA polymerase II elongation control | Q37992154 | ||
The super elongation complex (SEC) family in transcriptional control | Q38034905 | ||
Regulation of HIV-1 latency by chromatin structure and nuclear architecture. | Q38235100 | ||
Identification of a cyclin subunit required for the function of Drosophila P-TEFb | Q38337012 | ||
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells | Q38557763 | ||
Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV. | Q39023875 | ||
Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription | Q39173861 | ||
Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA. | Q39272683 | ||
Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function. | Q39685314 | ||
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP | Q39703646 | ||
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction | Q39712159 | ||
Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function. | Q40045693 | ||
Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR. | Q40118214 | ||
Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages. | Q41039158 | ||
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation. | Q41853689 | ||
Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells. | Q42052356 | ||
Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression | Q42112998 | ||
Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. | Q43447901 | ||
HIV-1 tat trans-activation requires the loop sequence within tar. | Q44349676 | ||
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation | Q46904254 | ||
Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytes | Q79254743 | ||
Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysis | Q79745144 | ||
Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophages | Q81579403 | ||
P433 | issue | 28 | |
P304 | page(s) | 4098-4102 | |
P577 | publication date | 2017-01-01 | |
P1433 | published in | Current Pharmaceutical Design | Q5195068 |
P1476 | title | The HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies | |
P478 | volume | 23 |
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Q89685627 | HIV-associated exosomes promote infection of Kaposi sarcoma-associated herpesvirus via epidermal growth factor receptor |
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Q89555196 | Human T-Cell Lymphotropic Virus Type 1 Transactivator Tax Exploits the XPB Subunit of TFIIH during Viral Transcription |
Q89782162 | P-TEFb as A Promising Therapeutic Target |
Q55285065 | SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy. |
Q54210140 | Targeting the Latent Reservoir for HIV-1. |
Q100503775 | The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein |
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