Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir

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Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.77.15.8227-8236.2003
P932PMC publication ID165222
P698PubMed publication ID12857891
P5875ResearchGate publication ID10664091

P2093author name stringB Matija Peterlin
Xin Lin
T S Benedict Yen
Laurence Huang
Dan Irwin
Satoshi Kanazawa
Joseph Romeo
P2860cites workDSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologsQ24328838
CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNAQ24550765
The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT proteinQ24680024
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexesQ28116607
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationQ28141291
Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic miceQ28143660
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcriptionQ28206012
The challenge of viral reservoirs in HIV-1 infectionQ28216956
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNAQ28263974
The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivationQ28361880
Reversible phosphorylation of the C-terminal domain of RNA polymerase IIQ29614790
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene productQ29615049
Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 PathwayQ63351477
Recovery of AIDS-associated retroviruses from patients with AIDS or AIDS-related conditions and from clinically healthy individualsQ68943219
Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapyQ77890124
In vivo protein transduction: delivery of a biologically active protein into the mouseQ29615482
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
An inducible transcription factor activates expression of human immunodeficiency virus in T cellsQ29618434
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Control of RNA initiation and elongation at the HIV-1 promoterQ29620157
P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase IIQ29620167
Cellular uptake of the tat protein from human immunodeficiency virusQ29620627
HIV-1 Tat protein trans-activates transcription in vitroQ30411837
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell linesQ33786066
Human immunodeficiency virus long terminal repeat responds to T-cell activation signalsQ34350307
Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latencyQ34362915
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study TeamQ34438252
Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator proteinQ34556566
Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcriptsQ35202038
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 proteinQ35211232
Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.Q36011366
Bidirectional activity of the rat insulin II 5'-flanking region in transgenic miceQ36833124
Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokinesQ36851755
Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology LaboratoriesQ37123606
The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.Q39580108
Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expressionQ39685303
A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells.Q39685470
Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.Q40045693
Secretion of glycosylation site mutants can be rescued by the signal/pro sequence of tissue plasminogen activatorQ40921091
Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.Q40990135
The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.Q41247263
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat proteinQ41349382
Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patientsQ41734588
Abnormal glucose handling by the kidney in response to hypoglycemia in type 1 diabetesQ43719971
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.Q43730164
Recombination: Multiply infected spleen cells in HIV patientsQ43923409
Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapyQ44196959
Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latencyQ44325918
Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gammaQ44506225
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapyQ45760702
Neurotoxicity of peptide analogues of the transactivating protein tat from Maedi-Visna virus and human immunodeficiency virusQ45787004
Expression and characterization of the trans-activator of HTLV-III/LAV virusQ45831293
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
Reduction of the HIV-1-infected T-cell reservoir by immune activation treatment is dose-dependent and restricted by the potency of antiretroviral drugs.Q52078801
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.Q53437454
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemiaQ57075698
Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genesQ59057041
The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic miceQ59060595
Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cellsQ59073388
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)8227-8236
P577publication date2003-08-01
P1433published inJournal of VirologyQ1251128
P1476titleTranscriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir
P478volume77

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