Reactivation of latent HIV: do all roads go through P-TEFb?

scientific article published on July 2013

Reactivation of latent HIV: do all roads go through P-TEFb? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/FVL.13.52
P932PMC publication ID3882155
P698PubMed publication ID24409197

P50authorAndrew P RiceQ55277928
P2093author name stringSona Budhiraja
P2860cites workAntiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infectionQ21142645
Translating the Histone CodeQ22065840
Selective inhibition of BET bromodomainsQ24301009
Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progressionQ24301464
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcriptionQ24316236
Active nuclear import of human immunodeficiency virus type 1 preintegration complexesQ24564507
Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acidQ24596282
7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcriptionQ24634280
Suberoylanilide hydroxamic acid reactivates HIV from latently infected cellsQ24644201
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcriptionQ24672881
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Depletion of latent HIV-1 infection in vivo: a proof-of-concept studyQ28111910
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexesQ28116607
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcriptionQ28206012
Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophagesQ28253165
Controlling the elongation phase of transcription with P-TEFbQ28255518
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4Q28267929
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replicationQ28368051
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosisQ29618035
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcriptionQ30835037
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infectionQ33476165
Chemokines and their receptors in lymphocyte traffic and HIV infectionQ33799800
Transcriptional and posttranscriptional regulation of HIV-1 gene expressionQ34030804
BET bromodomain inhibition as a novel strategy for reactivation of HIV-1Q34032827
Adverse effects of antiretroviral therapyQ34071132
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activityQ34123595
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.Q34249596
Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expressionQ42112998
Prostratin antagonizes HIV latency by activating NF-kappaB.Q43551279
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.Q43730164
Prolonged valproic acid treatment does not reduce the size of latent HIV reservoirQ46558493
OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD4+ T cell depletion.Q52019286
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemiaQ57218660
Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytesQ79254743
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
You bet-cha: a novel family of transcriptional regulatorsQ34327293
The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuitQ34544409
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcriptionQ34896128
HIV-1 pathogenesisQ35166833
Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.Q35804608
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Q35826285
HIV Restriction Factors and Mechanisms of EvasionQ35902681
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoproteinQ36332978
MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes.Q36404157
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitroQ36501927
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signalingQ36649160
The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivationQ36668708
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionQ36781531
DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1Q36828450
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase IIQ37103512
Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells.Q37119662
A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expressionQ37192141
Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitorsQ37257484
The challenge of finding a cure for HIV infectionQ37407598
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes.Q37429329
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirsQ37615893
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategiesQ37644561
Host proteins involved in HIV infection: new therapeutic targets.Q37657826
Facts and fiction: cellular models for high throughput screening for HIV-1 reactivating drugsQ37972644
HIV latencyQ37974218
Reactivation of latent HIV by histone deacetylase inhibitors.Q38091753
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cellsQ38557763
Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcriptionQ39173861
Reactivation of latent HIV-1 by inhibition of BRD4.Q39264882
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infectionQ39686599
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNPQ39703646
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cellsQ40435387
Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cellsQ40976774
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.Q41641646
Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.Q42052356
P433issue7
P577publication date2013-07-01
P1433published inFuture VirologyQ15751230
P1476titleReactivation of latent HIV: do all roads go through P-TEFb?
P478volume8

Reverse relations

cites work (P2860)
Q40391119Assays for precise quantification of total (including short) and elongated HIV-1 transcripts.
Q38213132Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators
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Q36515063Molecular mechanisms of HIV latency
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Q47098415The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.
Q36906001The effects of cocaine on HIV transcription

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