Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling.

scientific article

Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID5835697
P698PubMed publication ID29511600

P2093author name stringYun Wang
Qian Chen
Jing Luo
Bin Cheng
Ronghua Wang
Yawen Li
Jinlin Wang
Si Xiong
Xiju Wang
Zhenxiong Zhao
P2860cites workSignificance of CD90+ cancer stem cells in human liver cancerQ28266933
Hepatocellular carcinomaQ29616359
Accessories to the crime: functions of cells recruited to the tumor microenvironmentQ29620161
Stattic: a small-molecule inhibitor of STAT3 activation and dimerizationQ33264035
Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signalingQ33588191
IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathwayQ33591332
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenograftsQ33883897
Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathwayQ34658803
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinomaQ35808323
CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem CellsQ36007881
The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progressionQ36179636
Impact of stem cell marker expression on recurrence of TACE-treated hepatocellular carcinoma post liver transplantationQ36499912
Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancerQ36758895
Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cellsQ36905769
The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinomaQ36962663
Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.Q36963408
Interleukin-6 enhances cancer stemness and promotes metastasis of hepatocellular carcinoma via up-regulating osteopontin expressionQ37298268
Role of Notch signaling pathway in pancreatic cancerQ37679979
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells.Q37721155
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathwaysQ37820099
Tumor microenvironment for cancer stem cellsQ38585426
Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasisQ38712410
Essential role of Notch4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancerQ38720274
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.Q38735975
Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathwaysQ38769001
Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 SignalingQ38773961
GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs).Q39055237
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signalingQ39071833
The inhibitor of differentiation isoform Id1b, generated by alternative splicing, maintains cell quiescence and confers self-renewal and cancer stem cell-like propertiesQ39211879
STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cellsQ39444950
CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG RegulationQ39512947
Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cellsQ39678922
IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironmentQ39686296
Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cellsQ39899676
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cellsQ42090033
Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathwayQ42367898
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.Q43639734
Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinomaQ44811513
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver CancerQ50350640
LSD1 stimulates cancer-associated fibrobasts to drive Notch3-dependent self-renewal of liver cancer stem-like cellsQ52408144
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.Q53241163
Hepatectomy for hepatocellular carcinoma: toward zero hospital deathsQ74604755
miR-34a Sets the “Sweet Spot” for Notch in Colorectal Cancer Stem CellsQ86711119
P433issue2
P921main subjecthepatocellular carcinomaQ1148337
cancer-associated fibroblastQ42417562
P304page(s)302-316
P577publication date2018-02-01
P1433published inAmerican Journal of Cancer ResearchQ17511667
P1476titleCancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling.
P478volume8

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cites work (P2860)
Q59125685A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma
Q90481740An evolving paradigm of cancer stem cell hierarchies: therapeutic implications
Q91810602Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy
Q64236929Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
Q90625953Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling
Q99547453Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance
Q92977405Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
Q64901779Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression.
Q90235966Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
Q91791494JAK/STAT signaling in hepatocellular carcinoma
Q89578384MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells
Q64058113Peri-tumor fibroblasts promote tumorigenesis and metastasis of hepatocellular carcinoma via Interleukin6/STAT3 signaling pathway
Q64103031Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP
Q89667670Targeting cancer stem cell pathways for cancer therapy
Q64101613The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma
Q90140513The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts

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