The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma

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The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma is …
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scholarly articleQ13442814

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P356DOI10.7150/JCA.26847
P932PMC publication ID6485212
P698PubMed publication ID31031867

P2093author name stringQinfeng Huang
Junhong Li
Jinghui Zheng
Ailing Wei
P2860cites workNovel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells.Q55438944
Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of MiceQ58450501
Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replicationQ58740348
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High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinomaQ81351659
Deregulated expression of Notch receptors in human hepatocellular carcinomaQ81404608
Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathwayQ87366214
The down-regulation of Notch1 inhibits the invasion and migration of hepatocellular carcinoma cells by inactivating the cyclooxygenase-2/Snail/E-cadherin pathway in vitroQ87424241
C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signallingQ24337647
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisQ24608039
Cellular and molecular mechanisms of fibrosisQ24648892
Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?Q27025083
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiencyQ28203380
Cancer stem cell niche: the place to beQ28304007
Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factorsQ28513130
The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activitiesQ28587853
Cancer statistics, 2009Q29547625
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Distinct role of macrophages in different tumor microenvironmentsQ29614304
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesisQ29614537
Tumor metastasis: mechanistic insights and clinical challengesQ29617676
Notch signaling is essential for vascular morphogenesis in miceQ29620377
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesisQ33752236
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology.Q33762356
Notch signaling: the core pathway and its posttranslational regulationQ34017623
Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesisQ34110003
Association of Notch1 with vasculogenic mimicry in human hepatocellular carcinoma cell linesQ34371351
lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling.Q55181025
Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling.Q55333053
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell functionQ34456711
The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinomaQ34612059
Delta-like 4 induces notch signaling in macrophages: implications for inflammationQ34632202
Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signalingQ34986010
The role of non-parenchymal cells in liver growthQ35018045
Notch signaling and inherited disease syndromesQ35095915
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.Q35237526
Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinomaQ35551840
Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.Q35620884
Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in cultureQ35713428
Notch signaling in ocular vasculature development and diseasesQ35719022
Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defectsQ35748038
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicityQ35757997
Notch3 regulates the activation of hepatic stellate cellsQ35872127
Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinomaQ35889547
NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cellsQ36041643
The Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in Hepatocellular Carcinoma Cells via Suppressing Notch SignalingQ36048511
Expression features of SOX9 associate with tumor progression and poor prognosis of hepatocellular carcinomaQ36299435
Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in miceQ36421780
Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathwayQ36642168
Cancer stem cells in the development of liver cancerQ36793453
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinomaQ36881080
Epidemiology of hepatocellular carcinoma: consider the populationQ36930514
The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinomaQ36962663
Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.Q37136259
Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expressionQ37269259
Molecular mechanisms of hepatocellular carcinomaQ37323726
Cutaneous Notch signaling in health and disease.Q37340356
Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeuticsQ37355835
Liver stem cells and hepatocellular carcinomaQ37358938
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.Q37594746
Canonical and non-canonical Notch ligandsQ37785194
The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets.Q37800217
Notch signalling in solid tumours: a little bit of everything but not all the timeQ37867484
Possible roles of DLK1 in the Notch pathway during development and diseaseQ37986963
Hepatic stellate cells--the pericytes in the liverQ38071948
Review of angiogenesis in hepatocellular carcinomaQ38188582
Immunohistochemical localization of CD31, NOTCH1 and JAGGED1 proteins in experimentally induced polycystic ovaries of immature rats.Q38348674
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53Q38453169
Hepatitis B virus X protein and hypoxia‑inducible factor-1α stimulate Notch gene expression in liver cancer cellsQ38731239
Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cellsQ38768645
Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 SignalingQ38773961
The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis.Q38812340
Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy.Q38841311
Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinomaQ38946298
Downregulation of Notch1 inhibits the invasion of human hepatocellular carcinoma HepG2 and MHCC97H cells through the regulation of PTEN and FAK.Q38967283
Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathwayQ38975804
The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitorsQ39074784
Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cellsQ39291000
Morphologic Subtypes of Hepatocellular CarcinomaQ39307606
Notch1-Snail1-E-cadherin pathway in metastatic hepatocellular carcinomaQ39448366
Valproic acid inhibits human hepatocellular cancer cells growth in vitro and in vivoQ39519611
Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serumQ39804134
Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanismQ39869859
Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.Q39939616
Cancer statistics in China, 2015.Q40064386
Aberrant Notch3 and Notch4 expression in human hepatocellular carcinomaQ40094616
Prognostic value of Notch receptors in postsurgical patients with hepatitis B virus-related hepatocellular carcinomaQ40177991
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesisQ40191484
Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.Q40606801
Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver CancerQ40694809
Prognostic significance of Hes-1, a downstream target of notch signaling in hepatocellular carcinomaQ41730236
Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cellsQ42360452
Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinomaQ42652080
RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosisQ45124974
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisQ45345843
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.Q46127843
Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinomaQ46810766
Notch1 increases Snail expression under high reactive oxygen species conditions in hepatocellular carcinoma cellsQ46912092
Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.Q48444479
Lidamycin decreases CD133 expression in hepatocellular carcinoma via the Notch signaling pathway.Q49175481
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.Q51894736
Notch signaling: numb makes the difference.Q52734603
Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma.Q53306826
Downregulation of the Notch signaling pathway inhibits hepatocellular carcinoma cell invasion by inactivation of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor.Q54501578
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)1570-1579
P577publication date2019-01-01
P1433published inJournal of CancerQ6294901
P1476titleThe Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma
P478volume10

Reverse relations

cites work (P2860)
Q98564461Aspartate β-hydroxylase as a target for cancer therapy
Q92029927Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
Q98471403Liver progenitor cell-driven liver regeneration
Q91844086Protein-protein interaction modulators: advances, successes and remaining challenges
Q90724962The Roles of Notch Signaling in Liver Development and Disease

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