Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

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Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction. is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-018-22830-8
P932PMC publication ID5854571
P698PubMed publication ID29545582

P50authorHeikki RuskoahoQ18633591
Jarno SalonenQ56550083
Sini KinnunenQ59684387
Mika VälimäkiQ59684391
Jouni HirvonenQ61163249
Pauli OhukainenQ92150047
Marja A TölliQ114442475
Jaana RysäQ43523475
Raisa SerpiQ47504213
Ermei MäkiläQ41554703
Hélder A. SantosQ43143343
P2093author name stringErhe Gao
Zoltan Szabo
Alexandra Correia
Mónica P A Ferreira
P2860cites workCsx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heartQ24292433
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactorsQ24314957
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heartQ24606117
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Therapeutic Potential of Stem Cells Strategy for Cardiovascular DiseasesQ28068965
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoAQ28362213
The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene ExpressionQ28504813
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heartQ28509556
The transcription factor GATA-6 regulates pathological cardiac hypertrophyQ28512555
Posttranscriptional control of BNP gene expression in angiotensin II-induced hypertensionQ28569488
GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic programQ28569972
Cardiac p300 Is Involved in Myocyte Growth with Decompensated Heart FailureQ28576829
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factorsQ28589872
Gene regulatory networks in the evolution and development of the heartQ29619086
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytesQ29620599
Essential role of GATA-4 in cell survival and drug-induced cardiotoxicityQ30500787
Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte ViabilityQ57396510
Combinatorial interactions regulating cardiac transcriptionQ57968965
p38 Kinase rescues failing myocardium after myocardial infarction: evidence for angiogenic and anti-apoptotic mechanismsQ60667645
Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathwaysQ43865809
Chemical Enhancement of In Vitro and In Vivo Direct Cardiac ReprogrammingQ46195954
GATA-4 is an angiogenic survival factor of the infarcted heartQ46454363
Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heartQ47857175
Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.Q47877045
Emerging pharmacologic and structural therapies for hypertrophic cardiomyopathy.Q50259289
Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.Q52178778
Pressure overload increases GATA4 binding activity via endothelin-1.Q31825806
Cardiogenic small molecules that enhance myocardial repair by stem cellsQ33329047
Drug permeation across intestinal epithelial cells using porous silicon nanoparticles.Q33782859
Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseasesQ33852885
(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.Q34387893
A novel and efficient model of coronary artery ligation and myocardial infarction in the mouseQ34423842
Small molecules for cell reprogramming and heart repair: progress and perspectiveQ35076609
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failureQ35131260
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivoQ35134084
Natriuretic peptides and myocardial ischaemiaQ35667258
GATA transcription factors in the developing and adult heartQ35833907
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5.Q35862534
Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseasesQ36144681
In search of new therapeutic targets and strategies for heart failure: recent advances in basic scienceQ36364300
Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cellsQ36513042
Epidemiology and aetiology of heart failureQ36905978
Medical therapy for chronic heart failureQ37920401
Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac HypertrophyQ38023555
Early left ventricular gene expression profile in response to increase in blood pressure.Q38302190
Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factorsQ38360604
Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeuticsQ38654054
Adverse Remodeling and Reverse Remodeling After Myocardial InfarctionQ38665321
Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic SignalingQ38676235
In vitro and in vivo assessment of heart-homing porous silicon nanoparticlesQ38877084
Evolving approaches to heart regeneration by therapeutic stimulation of resident cardiomyocyte cell cycle.Q39016129
In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart.Q39166414
Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart DiseaseQ39371869
Ca2+–calmodulin‐dependent protein kinase II represses cardiac transcription of the L‐type calcium channel α1C‐subunit gene (Cacna1c) by DREAM translocationQ39559824
SUMO-1 modification activated GATA4-dependent cardiogenic gene activityQ40520891
Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.Q40675868
Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytesQ40693364
Heart repair by reprogramming non-myocytes with cardiac transcription factorsQ41859789
VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes.Q42031179
Targeting Native Adult Heart Progenitors with Cardiogenic Small MoleculesQ42203093
Combinatorial interactions regulating cardiac transcriptionQ42456434
Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomaliesQ42635760
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)4611
P577publication date2018-03-15
P1433published inScientific ReportsQ2261792
P1476titleCardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction
P478volume8

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cites work (P2860)
Q62923934Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration
Q90415843GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes
Q59792458Role of Overexpressed Transcription Factor FOXO1 in Fatal Cardiovascular Septal Defects in Patau Syndrome: Molecular and Therapeutic Strategies
Q89482564Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds
Q92731445Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators
Q92659552Targeting GATA4 for cardiac repair

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