Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.

scientific article published in March 1999

Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.274.12.8231
P698PubMed publication ID10075728

P2093author name stringY Yazaki
T Mizuno
T Yamazaki
S Kudoh
T Oka
I Komuro
E Takimoto
H Akazawa
I Shiojima
K Monzen
R Aikawa
Y Hiroi
P2860cites workThe cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactorsQ24314957
Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcriptionQ24315851
Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factorQ24337170
Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteinsQ24651577
NK-2 homeobox genes and heart developmentQ28290183
The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene ExpressionQ28504813
GATA4 transcription factor is required for ventral morphogenesis and heart tube formationQ28586495
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2CQ28589290
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart developmentQ28589858
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5Q28590994
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesisQ28592331
GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene ExpressionQ33774042
D-mef2 is a target for Tinman activation during Drosophila heart developmentQ33886060
tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of DrosophilaQ34335151
Csx: a murine homeobox-containing gene specifically expressed in the developing heartQ36513213
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.Q36552793
Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5.Q36709632
Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription FactorsQ40432858
Regulation of Cardiac Gene Expression by GATA-4/5/6.Q40897593
Molecular pathways controlling heart developmentQ40978315
The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structuresQ42459873
extradenticle raises the DNA binding specificity of homeotic selector gene productsQ46446845
Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryoQ47072261
XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development.Q48084784
Heart development in Drosophila requires the segment polarity gene winglessQ52207872
Heart development in Drosophila and its relationship to vertebratesQ52210652
dpp induces mesodermal gene expression in DrosophilaQ52212324
The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoproteinQ52541323
DNA bending and orientation-dependent function of YY1 in the c-fos promoterQ52544475
Molecular cloning and characterization of human cardiac homeobox gene CSX1Q71720423
Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac developmentQ72093904
A role for bone morphogenetic proteins in the induction of cardiac myogenesisQ73094521
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcooperationQ380962
P304page(s)8231-8239
P577publication date1999-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleContext-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
P478volume274

Reverse relations

cites work (P2860)
Q40746407A combination of cis-acting elements is required to activate the pro-alpha 1(I) collagen promoter in tendon fibroblasts of transgenic mice
Q42802264A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription
Q54338138A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect
Q24676848A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
Q34363879A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck
Q37506957A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders.
Q28595040Beating is necessary for transdifferentiation of skeletal muscle‐derived cells into cardiomyocytes
Q24554412Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4
Q55334799Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.
Q28510052Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
Q34075718Cell biology of cardiac development
Q28578096Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein
Q33745111Combinatorial codes in signaling and synergy: lessons from pituitary development
Q34126121Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity.
Q24675337Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
Q24307338Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C
Q28581318Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression
Q28508533Differential expression and function of Tbx5 and Tbx20 in cardiac development
Q33563970Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer
Q40693364Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes
Q36777832Extracting sequence features to predict protein-DNA interactions: a comparative study
Q34076853From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation
Q24290106Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
Q53621281Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system.
Q38307415GATA-4 and serum response factor regulate transcription of the muscle-specific carnitine palmitoyltransferase I beta in rat heart
Q28569972GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program
Q54454396GATA4 mutations in Chinese patients with congenital cardiac septal defects
Q90679951Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Q42505146Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes
Q24306881Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism
Q42911045Isolation, characterization, and transplantation of cardiac endothelial cells.
Q24629583Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease
Q37613372Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.
Q39354706Mutation spectrum of the GATA4 gene in patients with idiopathic atrial fibrillation
Q22010903Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Q34128429Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter
Q104070079Precision medicine for heart failure based on molecular mechanisms The Research Achievement Award Lecture
Q35757916Re-employment of developmental transcription factors in adult heart disease
Q34510777Regulation of heart development and function through combinatorial interactions of transcription factors
Q40806167Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
Q48479328Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways
Q24291385Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
Q35033150The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
Q35726290The Drosophila Transcription Factors Tinman and Pannier Activate and Collaborate with Myocyte Enhancer Factor-2 to Promote Heart Cell Fate
Q36695886The disruption of a novel limb cis-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis
Q38215321The functional diversity of essential genes required for mammalian cardiac development.
Q39362608The multifaceted role of natriuretic peptides in metabolic syndrome
Q24550992The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
Q42014461The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes
Q38023555Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac Hypertrophy
Q37493069Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells
Q64377125Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart
Q34562988Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart
Q28589686Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors
Q41974233Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression
Q40300654p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins

Search more.