18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.

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18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-27142-5
P932PMC publication ID6008326
P698PubMed publication ID29921924

P50authorZhao-Qi ZhangQ89158536
P2093author name stringJin Chen
Chao Wang
Zhao Huang
Xiao-Ping Chen
Jia Song
Liang Chu
Bi-Xiang Zhang
Hui-Fang Liang
Qiu-Meng Liu
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Q22676705
Regulation of endoplasmic reticulum turnover by selective autophagyQ24337913
Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapyQ26798462
Self-consumption: the interplay of autophagy and apoptosisQ26828473
Glycyrrhizic acid in the treatment of liver diseases: literature reviewQ26851465
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signalingQ45852778
Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells.Q46415201
Autophagy in the Pathogenesis of DiseaseQ27860558
JNK-induced apoptosis, compensatory growth, and cancer stem cellsQ28395713
Methods in mammalian autophagy researchQ29547276
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
How to interpret LC3 immunoblottingQ29614175
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.Q33559643
HMGB1-dependent and -independent autophagyQ34344751
Endoplasmic reticulum architecture: structures in flux.Q34684405
Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cellsQ34690743
JNK signaling in apoptosisQ34713366
Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathwayQ35073336
18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancerQ35138733
The role for autophagy in cancerQ35242506
Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cellsQ36685537
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.Q36870862
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.Q37375192
Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivoQ37482734
Laparoscopic and robotic approach for hepatocellular carcinoma-state of the artQ37568652
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathwayQ37594355
Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning.Q38176242
mTOR: a pharmacologic target for autophagy regulationQ38345168
ER Stress and AutophagyQ38590612
Glycyrrhetinic Acid and Its Derivatives: Anti-Cancer and Cancer Chemopreventive Properties, Mechanisms of Action and Structure- Cytotoxic Activity RelationshipQ38693942
Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2).Q38775227
Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by impairing the p38 MAPK-AP1 signaling axisQ38892406
18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathwayQ39016923
18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathwayQ39070051
Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stressQ39076560
18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathwayQ39302074
Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway.Q39416088
18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cellsQ39512103
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosisQ42207479
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)9365
P577publication date2018-06-19
P1433published inScientific ReportsQ2261792
P1476title18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma
P478volume8

Reverse relations

cites work (P2860)
Q92956445DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma
Q96768625Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?
Q90118163Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury
Q90482975Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway

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