Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches.

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Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches. is …
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scholarly articleQ13442814

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P356DOI10.3389/FNEUR.2018.00431
P932PMC publication ID6005348
P698PubMed publication ID29942281

P2093author name stringLaurence Bernard-Demanze
Michel Lacour
Brahim Tighilet
Isabelle Watabe
Jacques Léonard
P2860cites workNeuropharmacology of vestibular system disordersQ24624927
Betahistine for symptoms of vertigoQ26471456
Interaction between Vestibular Compensation Mechanisms and Vestibular Rehabilitation Therapy: 10 Recommendations for Optimal Functional RecoveryQ26825937
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Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig.Q51590373
Histaminergic H3-Heteroreceptors as a Potential Mediator of Betahistine-Induced Increase in Cochlear Blood Flow.Q53441843
Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo.Q53836613
Effects of histamine and betahistine on rat medial vestibular nucleus neurones: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sicknessQ53875138
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Mechanisms of recovery following unilateral labyrinthectomy: a reviewQ69520016
[Compensation deficits in posture and kinetics following unilateral vestibular neurectomy in cats. The role of sensorimotor activity]Q70713465
Betahistine dihydrochloride treatment facilitates vestibular compensation in the catQ72145042
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High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case seriesQ84230069
Betahistine treatment improves the recovery of static symptoms in patients with unilateral vestibular lossQ85183953
Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivoQ34321223
Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of actionQ34432126
Pharmacological treatment of vertigoQ35042682
Molecular mechanisms of brainstem plasticity. The vestibular compensation modelQ36472967
Modulation of histamine synthesis and release in brain via presynaptic autoreceptors and heteroreceptorsQ36601233
Plastic events in the vestibular nuclei during vestibular compensation: the brain orchestration of a "deafferentation" codeQ37677975
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BDNF Signaling Promotes Vestibular Compensation by Increasing Neurogenesis and Remodeling the Expression of Potassium-Chloride Cotransporter KCC2 and GABAA Receptor in the Vestibular NucleiQ39699187
'Vestibular compensation': neural plasticity and its relations to functional recovery after labyrinthine lesions in frogs and other vertebratesQ40418328
Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres diseaseQ40698894
Antivertigo medications and drug-induced vertigo. A pharmacological reviewQ40961261
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Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat.Q42485327
Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanismsQ44050769
New insights into vestibular neuropharmacology: from bench to bedsideQ44366552
Stress axis plasticity during vestibular compensation in the adult cat.Q46088953
Vestibular compensation revisitedQ46148407
Long-term prophylactic treatment of attacks of vertigo in Menière's disease--comparison of a high with a low dosage of betahistine in an open trialQ46637476
Effect of drug therapy on compensation from vestibular injuryQ46944892
Histaminergic ligands improve vestibular compensation in the cat: behavioural, neurochemical and molecular evidenceQ48134433
Responses of hypothalamic neurons to stimulation of the vestibular nerve and lateral vestibular nucleus in the rabbitQ48256713
Medial vestibular nucleus in the guinea-pig: histaminergic receptors. I. An in vitro studyQ48368564
Modifications and development of spinal reflexes in the alert baboon (Papio papio) following an unilateral vestibular neurotomyQ48369549
Sequential [(18)F]FDG µPET whole-brain imaging of central vestibular compensation: a model of deafferentation-induced brain plasticityQ48504273
Changes in the histaminergic system during vestibular compensation in the cat.Q48585081
Histamine immunoreactivity changes in vestibular-lesioned and histaminergic-treated catsQ48660648
Histamine release from the hypothalamus induced by gravity change in rats and space motion sicknessQ48699633
Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear modelQ48743204
Distribution of histaminergic axonal fibres in the vestibular nuclei of the cat.Q49053023
Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitroQ49098441
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)431
P577publication date2018-06-11
P1433published inFrontiers in NeurologyQ15817039
P1476titleBetahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches.
P478volume9

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