COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast

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COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast is …
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scholarly articleQ13442814

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P356DOI10.1007/S00428-007-0506-4
P698PubMed publication ID17851687

P50authorGiuseppe PerroneQ59208028
Sergio MoriniQ42827000
Vittorio AltomareQ45877460
P2093author name stringCarla Rabitti
Cleonice Battista
Mariagiovanna Zagami
P2860cites workCaveolin-1 is down-regulated and inversely correlated with HER2 and EGFR expression status in invasive ductal carcinoma of the breastQ46832775
Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell linesQ47978602
COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classificationQ56101234
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2Q70787131
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) geneQ71826297
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancerQ72312392
Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomainsQ73119457
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
Tumor cell growth inhibition by caveolin re-expression in human breast cancer cellsQ74392346
Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kineticsQ81403532
Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancerQ24318999
Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitorsQ25257303
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1Q27731226
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agentsQ27734207
Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblastsQ28204285
Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinasesQ28296324
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteinsQ28304307
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomainsQ33292451
Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cellsQ35607385
Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2Q36164895
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endotheliumQ36255255
Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin moleculeQ36256576
Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tractQ36296003
Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancerQ36695595
COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features.Q38443121
Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ.Q38457297
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell lineQ40694101
Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells.Q40880089
Role of type IIA secretory phospholipase A2 in arachidonic acid metabolismQ40901099
Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathwaysQ40978833
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopyQ42830105
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalitiesQ43678714
ERs associate with and regulate the production of caveolin: implications for signaling and cellular actionsQ43843581
P433issue6
P921main subjectintraepithelial neoplasiaQ6058399
P304page(s)1039-1045
P577publication date2007-09-13
P1433published inVirchows ArchivQ19059548
P1476titleCOX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast
P478volume451