CTLA-4 (CD152) enhances the Tc17 differentiation program

scientific article published on 30 May 2014

CTLA-4 (CD152) enhances the Tc17 differentiation program is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.201343497
P698PubMed publication ID24723371

P50authorMonika C Brunner-WeinzierlQ57950191
P2093author name stringGerhard Jorch
Dirk Schlüter
Gopala Nishanth
Holger Lingel
Magdalena Huber
Kerry Tedford
Klaus-Dieter Fischer
Aditya Arra
Jonas Pick
J Kolja Hegel
P2860cites workCD28 co-stimulation down regulates Th17 developmentQ21143804
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4Q24634871
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
CD28 and CTLA-4 coreceptor expression and signal transductionQ28244243
Reversal of the TCR stop signal by CTLA-4Q28259985
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγtQ28589692
T-cell quality in memory and protection: implications for vaccine designQ30014840
Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in miceQ33776452
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiationQ34041965
Effector and memory CD8+ T cell fate coupled by T-bet and eomesoderminQ34465675
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenanceQ34472025
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging studyQ34614776
The soluble isoform of CTLA-4 as a regulator of T-cell responsesQ34648178
Tc17 CD8 T cells: functional plasticity and subset diversity.Q34856750
Relative contributions of NK and CD8 T cells to IFN-gamma mediated innate immune protection against Listeria monocytogenesQ35098219
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumabQ35289145
Immune responses to Listeria monocytogenesQ35906097
Recent developments in the transcriptional regulation of cytolytic effector cellsQ35934180
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cellsQ36014992
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cellQ36170597
Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanismsQ36585688
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapyQ36677310
CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three casesQ36846646
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cellsQ37061893
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotypeQ37081632
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient miceQ37111353
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challengeQ37155421
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cellsQ37173259
Type 17 CD8+ T cells display enhanced antitumor immunity.Q37268980
IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons.Q37313268
Protumor vs antitumor functions of IL-17.Q37600557
CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.Q38343937
Tc17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse modelQ38457326
Low-strength T-cell activation promotes Th17 responses.Q39338146
IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.Q39450545
Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesisQ39714121
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activityQ39835072
Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.Q40132546
Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18.Q40700698
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.Q41899031
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitisQ42136819
A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ productionQ42604117
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.Q42739331
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expressionQ43828654
Early programming of T cell populations responding to bacterial infectionQ44560253
IL-23 drives pathogenic IL-17-producing CD8+ T cells.Q47976537
CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin.Q51815081
High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4).Q52927586
The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.Q53164307
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challengeQ56899966
CD4+ T Cells Disarm or Delete Cytotoxic T Lymphocytes under IL-17-Polarizing ConditionsQ62555862
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2139-2152
P577publication date2014-05-30
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleCTLA-4 (CD152) enhances the Tc17 differentiation program
P478volume44

Reverse relations

cites work (P2860)
Q38328539IL-17A-producing CD8(+)T cells as therapeutic targets in autoimmunity.
Q37546999Listeria monocytogenes-Induced Cell Death Inhibits the Generation of Cell-Mediated Immunity.
Q51084408The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.
Q39438071Yin and yang of interleukin-17 in host immunity to infection

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