The CD28-related molecule ICOS is required for effective T cell-dependent immune responses

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The CD28-related molecule ICOS is required for effective T cell-dependent immune responses is …
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scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(00)00011-X
P698PubMed publication ID10933398

P2093author name stringC E Rudd
T Nguyen
C Lloyd
J C Gutierrez-Ramos
M Gosselin
H Schneider
S Manning
J Tian
A J Coyle
J A Gonzalo
T Delaney
L R Owen
S Lehar
T Burwell
P2860cites workICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28Q22001503
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motifQ24310233
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cellsQ24680080
T-cell co-stimulation through B7RP-1 and ICOSQ28141589
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clonesQ28209894
CTLA-4 can function as a negative regulator of T cell activationQ28235866
Enhancement of antitumor immunity by CTLA-4 blockadeQ28275730
Interleukin-13: central mediator of allergic asthmaQ28291712
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21rasQ28300793
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalphaQ30807749
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.Q34224070
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation moleculeQ34298838
A two-step, two-signal model for the primary activation of precursor helper T cellsQ34797521
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma productionQ36362675
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.Q36364843
Limited role of CD28-mediated signals in T helper subset differentiationQ36367295
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationQ36368029
CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivoQ36375742
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus productionQ36380917
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetesQ36400199
CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.Q36400564
H. polygyrus: B7-independence of the secondary type 2 responseQ39436438
OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infectionQ40907799
Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsivenessQ41843358
Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infectionQ42753302
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactionsQ42806821
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.Q42947124
Functional responses and costimulator dependence of memory CD4+ T cells.Q52030310
CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis.Q52035494
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.Q54308518
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthmaQ56907759
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formationQ56908531
A cell culture model for T lymphocyte clonal anergyQ67299314
The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivoQ73257315
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmographyQ73730758
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)95-105
P577publication date2000-07-01
P1433published inImmunityQ6005457
P1476titleThe CD28-related molecule ICOS is required for effective T cell-dependent immune responses
P478volume13

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Q33872168Yin-Yang of costimulation: crucial controls of immune tolerance and function
Q89965819c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes

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