scholarly article | Q13442814 |
P356 | DOI | 10.1016/S1074-7613(00)00011-X |
P698 | PubMed publication ID | 10933398 |
P2093 | author name string | C E Rudd | |
T Nguyen | |||
C Lloyd | |||
J C Gutierrez-Ramos | |||
M Gosselin | |||
H Schneider | |||
S Manning | |||
J Tian | |||
A J Coyle | |||
J A Gonzalo | |||
T Delaney | |||
L R Owen | |||
S Lehar | |||
T Burwell | |||
P2860 | cites work | ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 | Q22001503 |
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif | Q24310233 | ||
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells | Q24680080 | ||
T-cell co-stimulation through B7RP-1 and ICOS | Q28141589 | ||
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones | Q28209894 | ||
CTLA-4 can function as a negative regulator of T cell activation | Q28235866 | ||
Enhancement of antitumor immunity by CTLA-4 blockade | Q28275730 | ||
Interleukin-13: central mediator of allergic asthma | Q28291712 | ||
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras | Q28300793 | ||
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 | Q29619280 | ||
B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha | Q30807749 | ||
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. | Q34224070 | ||
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule | Q34298838 | ||
A two-step, two-signal model for the primary activation of precursor helper T cells | Q34797521 | ||
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production | Q36362675 | ||
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. | Q36364843 | ||
Limited role of CD28-mediated signals in T helper subset differentiation | Q36367295 | ||
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation | Q36368029 | ||
CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo | Q36375742 | ||
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production | Q36380917 | ||
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes | Q36400199 | ||
CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen. | Q36400564 | ||
H. polygyrus: B7-independence of the secondary type 2 response | Q39436438 | ||
OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection | Q40907799 | ||
Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness | Q41843358 | ||
Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection | Q42753302 | ||
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions | Q42806821 | ||
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. | Q42947124 | ||
Functional responses and costimulator dependence of memory CD4+ T cells. | Q52030310 | ||
CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis. | Q52035494 | ||
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. | Q54308518 | ||
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma | Q56907759 | ||
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation | Q56908531 | ||
A cell culture model for T lymphocyte clonal anergy | Q67299314 | ||
The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo | Q73257315 | ||
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography | Q73730758 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 95-105 | |
P577 | publication date | 2000-07-01 | |
P1433 | published in | Immunity | Q6005457 |
P1476 | title | The CD28-related molecule ICOS is required for effective T cell-dependent immune responses | |
P478 | volume | 13 |
Q54977058 | "Immune TOR-opathies," a Novel Disease Entity in Clinical Immunology. |
Q38598814 | 14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency |
Q37026428 | A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. |
Q44476352 | A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection |
Q95319497 | A guide to cancer immunotherapy: from T cell basic science to clinical practice |
Q36236577 | A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation. |
Q28610409 | A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS) |
Q92150338 | AP-1 Transcription Factors as Regulators of Immune Responses in Cancer |
Q28511741 | AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling |
Q35848468 | Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation |
Q49030635 | Accelerated Airway Dendritic Cell Maturation, Trafficking, and Elimination in a Mouse Model of Asthma |
Q34517906 | Activation and inhibition of lymphocytes by costimulation |
Q58746553 | Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis |
Q34786974 | Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? |
Q34340571 | Altered T cell signalling in ageing |
Q47349199 | Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease |
Q37115223 | Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues |
Q49662013 | Anti-Inducible Costimulator Monoclonal Antibody Treatment of Canine Chronic Graft-versus-Host Disease |
Q34534351 | Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling |
Q30486421 | Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner |
Q24302386 | Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity |
Q56897469 | Association of Hashimoto's thyroiditis with cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and inducible co-stimulator (ICOS) genes in a Kuwaiti population |
Q34765268 | Asthma: an epidemic of dysregulated immunity |
Q42554635 | B and T lymphocyte attenuator regulates T cell survival in the lung |
Q34169250 | B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women. |
Q38129635 | B7 family checkpoint regulators in immune regulation and disease |
Q36185034 | B7 family molecules as regulators of the maternal immune system in pregnancy |
Q35607509 | B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses |
Q33715667 | B7h is required for T cell activation, differentiation, and effector function |
Q34300038 | B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses |
Q38338446 | Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278). |
Q92992303 | Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner |
Q36251308 | Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). |
Q37356373 | CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. |
Q73208123 | CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice |
Q47645432 | CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease |
Q41063787 | CD3+ICOS+ T cells show differences in the synthesis of nitric oxide, IFN-γ, and IL-10 in patients with pulmonary tuberculosis or in healthy household contacts. |
Q37069249 | CD86 has sustained costimulatory effects on CD8 T cells |
Q42370428 | Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation |
Q24645109 | Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells |
Q36371140 | Constitutive expression of the B7h ligand for inducible costimulator on naive B cells is extinguished after activation by distinct B cell receptor and interleukin 4 receptor-mediated pathways and can be rescued by CD40 signaling |
Q73588963 | Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses |
Q36026037 | Costimulation: critical pathways in the immunologic regulation of asthma |
Q35733851 | Costimulatory molecules and T-cell-B-cell interactions |
Q34187594 | Costimulatory pathways in transplantation |
Q34700403 | Cytokine memory of T helper lymphocytes |
Q34638212 | Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4 |
Q35105753 | Disruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis |
Q38357683 | Down-regulation of inducible co-stimulator (ICOS) by intravitreal injection of small interfering RNA (siRNA) plasmid suppresses ongoing experimental autoimmune uveoretinitis in rats |
Q37098142 | Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets |
Q35789338 | Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts |
Q39325384 | Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction |
Q38160477 | Emerging Co-signaling Networks in T Cell Immune Regulation |
Q24796946 | Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells |
Q81704177 | Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro |
Q37446021 | Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection |
Q51672373 | Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation. |
Q38070582 | Experimental advances in understanding allergic airway inflammation |
Q53625991 | Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function. |
Q42087961 | Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. |
Q28198548 | Expression of the Costimulatory Molecule B7-H2 (Inducible Costimulator Ligand) by Human Airway Epithelial Cells |
Q79769520 | Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression |
Q24676570 | Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production |
Q34097548 | Follicular homing T helper (Th) cells and the Th1/Th2 paradigm |
Q64376358 | Further study of anti-ICOS immunotherapy for rat cardiac allograft rejection |
Q36879648 | Genetic defects in common variable immunodeficiency |
Q28215982 | Genetics of type 1 diabetes mellitus |
Q34015403 | Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice |
Q37418386 | Histocompatibility methods. |
Q28072305 | ICOS Co-Stimulation: Friend or Foe? |
Q62734291 | ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis |
Q28187985 | ICOS co-stimulatory receptor is essential for T-cell activation and function |
Q79169969 | ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells |
Q35062102 | ICOS costimulation in inflammatory bowel disease. |
Q24291377 | ICOS costimulation: It's not just for TH2 cells anymore |
Q24299856 | ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells |
Q28589705 | ICOS is critical for CD40-mediated antibody class switching |
Q56905108 | ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses |
Q28594859 | ICOS is essential for effective T-helper-cell responses |
Q55222376 | ICOS signal facilitates Foxp3 transcription to favor suppressive function of regulatory T cells. |
Q92915743 | ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain |
Q24296273 | ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells |
Q35196224 | ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. |
Q35208767 | Immune regulation by novel costimulatory molecules |
Q36993451 | Immunological decision-making: how does the immune system decide to mount a helper T-cell response? |
Q35611780 | Immunology of B7-H1 and its roles in human diseases |
Q91816563 | Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells |
Q42440317 | Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2 |
Q43655794 | Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection |
Q47736332 | Importance of the inducible costimulator molecule for the induction of allergic immune responses and its decreased expression on T helper cells after venom immunotherapy |
Q37238638 | In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. |
Q36403375 | In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma |
Q36811763 | Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus |
Q54609816 | Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis. |
Q35527988 | Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L |
Q33514875 | Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells |
Q33896026 | Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection |
Q44972273 | Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes |
Q33605239 | Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies |
Q46061458 | Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity |
Q44419299 | Induction of immunologic tolerance to cardiac allograft by simultaneous blockade of inducible co-stimulator and cytotoxic T-lymphocyte antigen 4 pathway1 |
Q75200122 | Informatics and the immune system: the expanding IL-1 and B7 protein families |
Q35670810 | Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression |
Q24805693 | Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia. |
Q47782299 | Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice |
Q34992448 | Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy |
Q52955868 | Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections |
Q59005464 | It takes more than two to tango |
Q41191163 | Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms |
Q24674583 | Ligand binding sites of inducible costimulator and high avidity mutants with improved function |
Q42149294 | Loss of Immune Tolerance Is Controlled by ICOS in Sle1 Mice. |
Q36851026 | Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T cells |
Q28208475 | Microanatomical localization of PD-1 in human tonsils |
Q36494214 | Modification of accessory molecule signaling |
Q42637857 | Molecular cloning and characterization of canine ICOS. |
Q56903870 | More negative feedback? |
Q34212495 | Mouse models of allergic airway disease |
Q34987302 | New regulatory co-receptors: inducible co-stimulator and PD-1. |
Q55383705 | Next generation immune-checkpoints for cancer therapy. |
Q34415795 | Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP |
Q36371325 | OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation |
Q39598751 | OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling |
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Q91816062 | Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses |
Q28609463 | PIP3 pathway in regulatory T cells and autoimmunity |
Q35053704 | Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice |
Q92852963 | Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells |
Q53912899 | Regulation of immune and autoimmune responses by ICOS. |
Q36592988 | Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses |
Q54732704 | Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells. |
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