A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II

scientific article published in Journal of Biological Chemistry

A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M700531200
P698PubMed publication ID17475626

P50authorPierre De MeytsQ18209260
Yvonne JonesQ21258635
Terrence D. MulhernQ54965497
Briony E. ForbesQ55381253
James BrownQ103447269
P2093author name stringJohn C Wallace
Carlie Delaine
Clair L Alvino
Kerrie A McNeil
Lisbeth Gauguin
P2860cites workStructure of a functional IGF2R fragment determined from the anomalous scattering of sulfurQ27638084
Structural origins of the functional divergence of human insulin-like growth factor-I and insulinQ27639399
Mannose 6-phosphate receptors: new twists in the taleQ28213265
The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?Q28262838
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosityQ28284646
Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptorQ28304234
Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibodyQ28577853
Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.Q30159824
Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance dataQ31043202
Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptorQ33204722
M6P/IGF2R imprinting evolution in mammalsQ33908331
Structural biology of insulin and IGF1 receptors: implications for drug designQ34152764
Selection of specific wheat germ agglutinin-resistant (WgaR) phenotypes from Chinese hamster ovary cell populations containing numerous lecR genotypesQ36956928
Identification of residues essential for carbohydrate recognition by the insulin-like growth factor II/mannose 6-phosphate receptorQ38292872
Europium-labeled epidermal growth factor and neurotensin: novel probes for receptor-binding studiesQ40754704
Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: the effects of domain 13 and pH.Q40813493
Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificitiesQ41147590
Mutations at Positions 11 and 60 of Insulin‐Like Growth Factor 1 Reveal Differences between its Interactions with the Type I Insulin‐Like‐Growth‐Factor Receptor and the Insulin ReceptorQ41289693
Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutationQ41920574
Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-IIQ42811185
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor bindingQ42815826
Mutations in the B-domain of insulin-like growth factor-I influence the oxidative folding to yield products with modified biological propertiesQ42826197
Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.Q42828008
Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificityQ43866672
Localization of the carbohydrate recognition sites of the insulin-like growth factor II/mannose 6-phosphate receptor to domains 3 and 9 of the extracytoplasmic regionQ44175842
Mutants of human insulin-like growth factor II: Expression and characterization of analogs with a substitution of Tyr27 and/or a deletion of residues 62–67Q44728479
Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and developmentQ45171483
Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.Q46407645
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgroundsQ47645757
Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu 3, following their expression in Escherichia coli as fusion proteinsQ54684248
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)18886-18894
P577publication date2007-05-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleA novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II
P478volume282

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cites work (P2860)
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Q57814928Chemical Synthesis of a Fluorescent IGF-II Analogue
Q53173338Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R.
Q36930975Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist
Q37596299Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion
Q33872525Insulin-like growth factors I and II receptors in the breast cancer survival disparity among African-American women
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Q89782321Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy
Q34719875Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor
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Q84563006The molecular basis of IGF-II/IGF2R recognition: a combined molecular dynamics simulation, free-energy calculation and computational alanine scanning study
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