Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

article

Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1742-4658.2011.08410.X
P698PubMed publication ID22044483

P50authorMaris LapinsQ30046335
Helgi B. SchiöthQ30112644
P2093author name stringJanis Klovins
Vita Ignatovica
Kaspars Megnis
P2860cites workADP is the cognate ligand for the orphan G protein-coupled receptor SP1999Q24290587
Identification of the platelet ADP receptor targeted by antithrombotic drugsQ24290845
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleedingQ24294523
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factorQ24317407
Heteromeric association creates a P2Y-like adenosine receptorQ24629017
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyQ24629255
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistQ24654563
Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysisQ24682069
Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma CellsQ25255546
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expressionQ28131772
Pharmacological profiles of cloned mammalian P2Y-receptor subtypesQ28279497
Regulation of platelet functions by P2 receptorsQ28290720
Structural diversity of G protein-coupled receptors and significance for drug discoveryQ29616716
Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteinsQ30421728
Clopidogrel: the future choice for preventing platelet activation during coronary stenting?Q33703725
Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptorQ34169728
Cloning and chromosomal localization of the human P2Y1 purinoceptorQ34373174
Towards a revised nomenclature for P1 and P2 receptorsQ34424522
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsinQ35081967
The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.Q36253724
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.Q36311516
Functions of neuronal P2Y receptorsQ36476011
Structural and functional evolution of the P2Y(12)-like receptor groupQ37135510
Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.Q37143313
Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modelingQ39856092
Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysisQ39935195
Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptorQ39937155
Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptorQ40083620
A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom CoprinusQ42232820
Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiaeQ42824946
Extensions to amino acid descriptionQ43235981
Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutationsQ44772930
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptorQ44988369
New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acidsQ47893213
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)180-191
P577publication date2011-11-23
P1433published inFEBS JournalQ1388041
P1476titleIdentification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system
P478volume279

Reverse relations

cites work (P2860)
Q39017052A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding
Q27683598Agonist-bound structure of the human P2Y12 receptor
Q38943762Comparison of common platelet receptors between the chacma baboon (Papio ursinus) and human for use in pre-clinical human-targeted anti-platelet studies
Q34442730Extracellular ATP, a danger signal, is recognized by DORN1 in Arabidopsis
Q34455950Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.
Q27316009Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information
Q38077232Molecular mechanisms of platelet P2Y(12) receptor regulation
Q35897845Nucleotides Acting at P2Y Receptors: Connecting Structure and Function
Q28264649P2Y12 receptors: structure and function
Q50105318Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding.
Q27682517Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Q87026094The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity