Comparison of the Efficacy of Zolmitriptan and Sumatriptan: Issues in Migraine Trial Design

article by G Geraud et al published February 2000 in Cephalalgia

Comparison of the Efficacy of Zolmitriptan and Sumatriptan: Issues in Migraine Trial Design is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1046/J.1468-2982.2000.00004.X
P698PubMed publication ID10817444

P50authorPeer Carsten Tfelt-HansenQ78649226
Jes OlesenQ29643374
P2093author name stringH-C Diener
V Pfaffenrath
R Zupping
G Geraud
R Sweet
P2860cites workOptimizing the dose of zolmitriptan (Zomig, 311C90) for the acute treatment of migraine. A multicenter, double-blind, placebo-controlled, dose range-finding study. The 017 Clinical Trial Study GroupQ39452008
Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headacheQ39485720
Methodology of clinical trials of sumatriptan in migraine and cluster headacheQ39513382
311C90: increasing the options for therapy with effective acute antimigraine 5HT1B/1D receptor agonistsQ41384969
Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraineQ41661654
Intensity dependence of the cortical auditory evoked potentials as a surrogate marker of central nervous system serotonin transmission in man: demonstration of a central effect for the 5HT1B/1D agonist zolmitriptan (311C90, Zomig).Q48547455
Direct evidence for central sites of action of zolmitriptan (311C90): an autoradiographic study in cat.Q48715691
Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?Q48896233
Zolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding studyQ57024812
Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factorsQ34608627
Prevalence and sex-ratio of the subtypes of migraine.Q34721342
Inhibition by sumatriptan of central trigeminal neurones only after blood-brain barrier disruptionQ36329540
Joint 1994 Wolff Award Presentation. Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (5HT)-1D receptor agonist 311C90.Q36723711
Verbal scales in the acute treatment of migraine: semantic categories and clinical relevance.Q38457483
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmigraineQ133823
P304page(s)30-38
P577publication date2000-02-01
P1433published inCephalalgiaQ5063251
P1476titleComparison of the Efficacy of Zolmitriptan and Sumatriptan: Issues in Migraine Trial Design
P478volume20

Reverse relations

cites work (P2860)
Q34524980A quantification of the placebo response in migraine prophylaxis
Q36380205AVP-825 breath-powered intranasal delivery system containing 22 mg sumatriptan powder vs 100 mg oral sumatriptan in the acute treatment of migraines (The COMPASS study): a comparative randomized clinical trial across multiple attacks
Q28192002Advances in pharmacological treatment of migraine
Q57847675Application of the BRAT Framework to Case Studies: Observations and Insights
Q34558594Assessing the efficacy of drugs for the acute treatment of migraine: issues in clinical trial design
Q37008907Clinical pharmacology of the serotonin receptor agonist, zolmitriptan
Q37177502Combining proof-of-concept with dose-finding: utilization of adaptive designs in migraine clinical trials
Q42673932Distribution of intranasal C-zolmitriptan assessed by positron emission tomography
Q36260908Does sumatriptan cross the blood-brain barrier in animals and man?
Q34155949Drug comparisons: why are they so difficult?
Q40385073Economic and patient-reported outcomes of oral triptans in the treatment of migraine
Q30646143Effect of encapsulation on absorption of sumatriptan tablets: data from healthy volunteers and patients during a migraine
Q35209630Ethical aspects of placebo in migraine research
Q40219739Factors associated with the prophylactic effect of placebo injections in subjects enrolled in a study of botulinum toxin for migraine.
Q30692301How does almotriptan compare with other triptans? A review of data from placebo-controlled clinical trials
Q34691359Marketed oral triptans in the acute treatment of migraine: a systematic review on efficacy and tolerability
Q30831647Network meta-analysis of migraine disorder treatment by NSAIDs and triptans
Q35822040OnabotulinumtoxinA for chronic migraine: a critical appraisal.
Q36511332Optimizing migraine therapy: evidence-based and patient-centered care
Q24203742Oral sumatriptan for acute migraine
Q24248078Oral sumatriptan for acute migraine
Q39356656Oral sumatriptan for the acute treatment of probable migraine: first randomized, controlled study
Q39381589Patient preference in clinical trials for headache medication: the patient's view
Q34235325Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review
Q36013751Placebo effects in oral triptan trials: the scientific and ethical rationale for continued use of placebo controls
Q46377572Randomized, double-blind, placebo-controlled, parallel-group, multi-center study of the safety and efficacy of ADAM zolmitriptan for the acute treatment of migraine
Q35194407Safety profile of the triptans
Q24203707Sumatriptan (oral route of administration) for acute migraine attacks in adults
Q38066258Sumatriptan: a review of its pharmacokinetics, pharmacodynamics and efficacy in the acute treatment of migraine
Q39384899The 40-mg dose of eletriptan: comparative efficacy and tolerability versus sumatriptan 100 mg.
Q34813721The importance of placebo in headache research
Q35107741The triptan formulations : how to match patients and products
Q34205890The triptan formulations: a critical evaluation
Q79385330Treatment of headache pain with botulinum neurotoxins
Q35696691Triptans and chest symptoms: the role of pulmonary vasoconstriction
Q35610934Triptans for treatment of acute pediatric migraine: a systematic literature review
Q34127399Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy
Q46955158Triptans in the treatment of migraine: drug selection by means of the SOJA method
Q34548435Triptans: do they differ?
Q88754393Use of Most Bothersome Symptom as a Coprimary Endpoint in Migraine Clinical Trials: A Post-Hoc Analysis of the Pivotal ZOTRIP Randomized, Controlled Trial
Q44171180Which triptan is best? Rating of triptans in migraine treatment
Q36107241Zolmitriptan (Zomig).
Q24194592Zolmitriptan for acute migraine attacks in adults

Search more.