Phase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis

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Phase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJMOA1803484
P932PMC publication ID6151253
P698PubMed publication ID30280651

P50authorRobert J. WilkinsonQ30423489
Marie-Ange DemoitiéQ114445751
Mookho MalahlehaQ114726200
Dereck R TaitQ116996640
Videlis NdubaQ116996641
Elana Van BrakelQ116996642
German HenostrozaQ116996643
Gretta L BlatnerQ116996644
Tina SinghQ116996645
Elaine J AkiteQ116996646
Anne BollaertsQ116996647
Helen AylesQ42761866
Michele TamerisQ55396247
Friedrich ThienemannQ55523569
Olivier Van Der MeerenQ58870759
Aisha Khatoon AzamQ58870762
Mark HatherillQ76888530
Thomas J ScribaQ77299176
Monde MuyoyetaQ81746849
Paul GillardQ91747664
Ann M GinsbergQ100512400
Neil A MartinsonQ105452530
Thomas G. EvansQ110768333
Andreas H DiaconQ114419745
P2093author name stringJames C Innes
Elizabeth Hellström
P2860cites workCloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosisQ28486541
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trialQ29620144
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosisQ30235074
The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical ModellingQ30244104
Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family.Q30638583
Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South AfricaQ33723554
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South AfricaQ33867491
Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyproteinQ34034191
Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli.Q34492873
Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adultsQ37186951
A Randomized, Controlled Safety, and Immunogenicity Trial of the M72/AS01 Candidate Tuberculosis Vaccine in HIV-Positive Indian AdultsQ37204894
A randomized, controlled dose-finding Phase II study of the M72/AS01 candidate tuberculosis vaccine in healthy PPD-positive adultsQ37301506
Systematic review of mathematical models exploring the epidemiological impact of future TB vaccinesQ37473293
The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigsQ37582822
Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trialsQ38171263
Heterogeneity in tuberculosis.Q38665662
Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study.Q38875343
Animal Models of Tuberculosis: An OverviewQ38977799
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trialQ39984692
Safety and immunogenicity of the M72/AS01E candidate tuberculosis vaccine in adults with tuberculosis: A phase II randomised studyQ40565756
Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis--specific CD8+ T cellsQ40704217
Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic settingQ41162993
Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitisQ41860986
Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine in HIV-infected adults on combination antiretroviral therapy: a phase I/II, randomized trialQ42211419
Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trialQ42683018
Prevention of tuberculosis in Bacille Calmette-Guérin-primed, HIV-infected adults boosted with an inactivated whole-cell mycobacterial vaccineQ43179227
Comparison of mantoux skin test with three generations of a whole blood IFN-gamma assay for tuberculosis infectionQ46175365
Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South AfricaQ46209425
Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant proteinQ47371281
Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial.Q49161794
Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine when given as a booster to BCG in Gambian infants: an open-label randomized controlled trial.Q53826203
Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination.Q55617820
In vitro cellular immune responses to complex and newly defined recombinant antigens of Mycobacterium tuberculosisQ80576923
P407language of work or nameEnglishQ1860
P921main subjecttuberculosisQ12204
P577publication date2018-09-25
P1433published inThe New England Journal of MedicineQ582728
P1476titlePhase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis

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cites work (P2860)
Q64260919A Case for Antibodies as Mechanistic Correlates of Immunity in Tuberculosis
Q64069523A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates
Q91321521A new tuberculosis vaccine: breakthrough, challenges, and a call for collaboration
Q97644982A novel formulation of Mtb72F DNA vaccine for immunization against tuberculosis
Q94555050A phase 1b randomized study of the safety and immunological responses to vaccination with H4:IC31, H56:IC31, and BCG revaccination in Mycobacterium tuberculosis-uninfected adolescents in Cape Town, South Africa
Q91311589A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime - MVA85A boost in healthy UK adults
Q90384542A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies
Q89866252Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells
Q64080155Addressing critical needs in the fight to end tuberculosis with innovative tools and strategies
Q92597111Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity
Q91384550Adolescent tuberculosis
Q98513693Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health
Q91562435Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection
Q90988221Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study
Q64080157Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial
Q92725408Analysis of cellular and soluble profiles in QuantiFERON nonconverters, converters, and reverters in the Gambia
Q90401221Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action
Q100512382Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans
Q64289721Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques
Q91558311Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccines
Q92572142Building a tuberculosis-free world: The Lancet Commission on tuberculosis
Q64937268CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.
Q64120774CXCR6-Deficiency Improves the Control of Pulmonary and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs
Q89965652Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups
Q90129924Challenges and controversies in childhood tuberculosis
Q89820519Clinical Development of New TB Vaccines: Recent Advances and Next Steps
Q90560580Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity
Q62898356Contemporary Concise Review 2018: Respiratory infections and tuberculosis
Q64375071Current trends in tuberculosis vaccine
Q97092975DNA vaccination with the Mycobacterium marinum MMAR_4110 antigen inhibits reactivation of a latent mycobacterial infection in the adult Zebrafish
Q64069762Designing tuberculosis vaccine efficacy trials - lessons from recent studies
Q100416704Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status
Q92084132Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein E co-lyophilized with a cationic liposome-based adjuvant in mice
Q92241929Evaluating vaccination strategies for tuberculosis in endemic and non-endemic settings
Q95267770Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques
Q91675421Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine
Q99609312Expanding the role of bacterial vaccines into life-course vaccination strategies and prevention of antimicrobial-resistant infections
Q64051922Harnessing donor unrestricted T-cells for new vaccines against tuberculosis
Q94948555Homoplastic single nucleotide polymorphisms contributed to phenotypic diversity in Mycobacterium tuberculosis
Q64118110Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates
Q90265933Immunogenicity and Safety of the M72/AS01E Candidate Vaccine Against Tuberculosis: A Meta-Analysis
Q92580249Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1
Q90043675Inoculum size and traits of the infecting clinical strain define the protection level against Mycobacterium tuberculosis infection in a rabbit model
Q92645553Insights and challenges in tuberculosis vaccine development
Q90999771Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model
Q90779193Meeting report: Global vaccine and immunization research forum, 2018
Q111441919Meeting report: Virtual Global Forum on Tuberculosis Vaccines, 20–22 April 2021
Q92199317Moving tuberculosis vaccines from theory to practice
Q61447731Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Infection
Q89667024Mycobacterial virulence: impact on immunogenicity and vaccine research
Q92551553Need for BCG Vaccination to Prevent TB in High-Incidence Countries and Populations
Q93097829New hope for tuberculosis vaccines
Q91306742Preferred product characteristics for therapeutic vaccines to improve tuberculosis treatment outcomes: Key considerations from World Health Organization consultations
Q92645576Prospects and challenges of a new live tuberculosis vaccine
Q91588330Quality matters: Redefining child TB care with an emphasis on quality
Q64107587Research and development of new tuberculosis vaccines: a review
Q90131082Response to comment on: Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity
Q104286463Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial
Q90147842Selection of adjuvants for vaccines targeting specific pathogens
Q92282330Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases
Q92056148Spotting the old foe-revisiting the case definition for TB
Q92611221Strategies for ending tuberculosis in the South-East Asian Region: A modelling approach
Q90752630Systematic review protocol on Bacillus Calmette-Guerin (BCG) revaccination and protection against tuberculosis
Q60956136T Cell Memory to Vaccination
Q92487060TIPICO IX: report of the 9th interactive infectious disease workshop on infectious diseases and vaccines
Q91969406The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection
Q91837155The Many Hosts of Mycobacteria 8 (MHM8): A conference report
Q60956638The Wonder Years: What Can Primary School Children Teach Us About Immunity to ?
Q64243683The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases
Q92056163The way forward for tuberculosis vaccines
Q90439703Towards new TB vaccines
Q92572130Tuberculosis
Q89724634Tuberculosis vaccine development: from classic to clinical candidates
Q64098097Tuberculosis vaccines: Rising opportunities
Q93195877Tuberculosis: the story after the Primer
Q92639851Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review
Q90345218Vaccination Against Tuberculosis: Revamping BCG by Molecular Genetics Guided by Immunology
Q60307189Vaccines: An achievement of civilization, a human right, our health insurance for the future

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