A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

scientific article published on 6 October 2018

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES23102545
P932PMC publication ID6222300
P698PubMed publication ID30301207

P50authorSimona CollinaQ57019072
Viviana GattaQ91280493
Päivi TammelaQ43259172
P2093author name stringFabrizio Giordanetto
Federico Medda
Anna Karawajczyk
Dimitrios Tzalis
Silvia Stotani
Mohan Padmanaban
P2860cites workQuorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer productionQ24672151
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Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand RecognitionQ27679978
Quorum sensing: cell-to-cell communication in bacteriaQ29547325
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Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial speciesQ30528603
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Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.Q34345959
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Interspecies and interkingdom communication mediated by bacterial quorum sensingQ37196178
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AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosusQ60587199
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Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1Q78055711
Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growthQ79780157
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Direct, catalytic synthesis of carbapenams via cycloaddition/rearrangement cascade reaction: unexpected acetylenes' structure effectQ85227897
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Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of actionQ40165584
Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coliQ40731005
C4-alkoxy-HPD: a potent class of synthetic modulators surpassing nature in AI-2 quorum sensingQ41831822
An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analoguesQ42192198
Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activationQ42543437
Carboxylic Acid-Promoted Copper(I)-Catalyzed Azide−Alkyne CycloadditionQ42904816
Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomerQ43121842
Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuousQ43244671
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activityQ43812035
A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrolQ45205971
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediatesQ46376078
Chemical synthesis of (S)-4,5-dihydroxy-2,3-pentanedione, a bacterial signal molecule precursor, and validation of its activity in Salmonella typhimurium.Q46404123
Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.Q46816379
Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analoguesQ50027811
An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing.Q50044270
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteriaQ50073839
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectquorum sensingQ905754
P577publication date2018-10-06
P1433published inMoleculesQ151332
P1476titleA Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing
P478volume23

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cites work (P2860)
Q90462354Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria
Q90432719Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It
Q93049304Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors

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