Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer

scientific article published on 05 November 2014

Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1586/14737159.2015.976557
P698PubMed publication ID25370828

P50authorJosephine C. AdamsQ52087156
P2093author name stringJosephine C Adams
P2860cites workCancer genome landscapesQ22242276
Migrastatin analogues target fascin to block tumour metastasisQ24306715
Tumor self-seeding by circulating cancer cellsQ24658224
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Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitroQ24684410
Actin structure-dependent stepping of myosin 5a and 10 during processive movementQ27306218
Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking proteinQ27661102
Mechanism of Actin Filament Bundling by FascinQ27670479
Molecular Mechanism of Fascin Function in Filopodial FormationQ27675250
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancerQ28237051
Naturally occurring antibodies devoid of light chainsQ28269589
Fascins, a family of actin bundling proteinsQ28282915
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancerQ28506447
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Mechanism of filopodia initiation by reorganization of a dendritic networkQ29616648
Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalizationQ30009497
Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikisQ39020527
The formin Daam1 and fascin directly collaborate to promote filopodia formation.Q39126569
The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitroQ39801876
Rac regulates the interaction of fascin with protein kinase C in cell migrationQ39948787
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Self-assembly of filopodia-like structures on supported lipid bilayersQ42360649
Directional transport by nonprocessive motor proteins on fascin-cross-linked actin arraysQ43743089
The filamentous actin cross-linking/bundling activity of mammalian formins.Q46331574
In colon carcinogenesis, the cytoskeletal protein gelsolin is down-regulated during the transition from adenoma to carcinoma.Q53318985
PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.Q54393310
A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.Q30424110
Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasisQ30480311
Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with FascinQ30574577
Cofilin cooperates with fascin to disassemble filopodial actin filamentsQ30581893
Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomasQ33259830
Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cellsQ33425930
Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancerQ33499383
MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1.Q33555201
Stress-induced cleavage of Myc promotes cancer cell survivalQ33588071
Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancerQ33700204
The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repairQ33827631
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodiaQ33840016
A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.Q34392217
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?Q34536800
Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysisQ34901665
Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.Q35217165
Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant KrasQ35565497
Review article: colorectal carcinoma and inflammatory bowel diseaseQ35880374
Fascin promotes filopodia formation independent of its role in actin bundlingQ35962314
MicroRNAs and other non-coding RNAs as targets for anticancer drug developmentQ35994443
Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42Q36328771
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersectionQ36542334
Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinomaQ36610155
Fascin-1 is a novel biomarker of aggressiveness in some carcinomasQ36766973
The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasisQ37289259
Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parametersQ37363722
The roles of fascins in health and diseaseQ37880684
Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and NotchQ38049051
What are the best routes to effectively model human colorectal cancer?Q38087005
Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?Q38397212
Prognostic Impact of Fascin-1 Expression is More Significant in Advanced Colorectal CancerQ38481579
Characterization of cell-matrix adhesion requirements for the formation of fascin microspikesQ38614984
Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion.Q38976962
Fascin plays a role in stress fiber organization and focal adhesion disassembly.Q38984596
P433issue1
P921main subjectcolorectal cancerQ188874
biomarkerQ864574
colorectal carcinomaQ25493920
P304page(s)41-48
P577publication date2014-11-05
P1433published inExpert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcareQ15756305
P1476titleFascin-1 as a biomarker and prospective therapeutic target in colorectal cancer
P478volume15

Reverse relations

cites work (P2860)
Q91801838"Biological Adhesion" is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
Q33459386Analysis of Fascin-1 in Relation to Gleason Risk Classification and Nuclear ETS-Related Gene Status of Human Prostate Carcinomas: An Immunohistochemical Study of Clinically Annotated Tumours From the Wales Cancer Bank
Q35822059Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer
Q37132873Deciphering glycomics and neuroproteomic alterations in experimental traumatic brain injury: Comparative analysis of aspirin and clopidogrel treatment
Q89666780Effects of Galectin-1 on Biological Behavior in Cervical Cancer
Q36116616Expression of Fascin-1 on human lung cancer and paracarcinoma tissue and its relation to clinicopathological characteristics in patients with lung cancer
Q38793478Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling
Q38750488Fascin Regulates Nuclear Movement and Deformation in Migrating Cells
Q89771439Investigation of promoter methylation of FSCN1 gene and FSCN1 protein expression in differentiated thyroid carcinomas
Q38592713Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression

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