| scholarly article | Q13442814 |
| P2093 | author name string | George Sigounas | |
| Fred E Bertrand | |||
| C William Angus | |||
| William J Partis | |||
| P2860 | cites work | TGF-beta signal transduction | Q22003891 |
| Global cancer statistics | Q22241238 | ||
| Two genetic hits (more or less) to cancer | Q22251289 | ||
| Identification of c- MYC as a Target of the APC Pathway | Q24310637 | ||
| TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms | Q24320364 | ||
| Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC | Q24336321 | ||
| Comprehensive molecular characterization of human colon and rectal cancer | Q24630415 | ||
| Wnt/β-Catenin Signaling and Disease | Q26823272 | ||
| A genetic model for colorectal tumorigenesis | Q27860582 | ||
| Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing | Q27860948 | ||
| Identification of stem cells in small intestine and colon by marker gene Lgr5 | Q28131701 | ||
| Notch signaling: from the outside in | Q28139768 | ||
| The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling | Q28182102 | ||
| The Hedgehog and Wnt signalling pathways in cancer | Q28189485 | ||
| Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter | Q28203084 | ||
| HES and HERP families: multiple effectors of the Notch signaling pathway | Q28205103 | ||
| Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths | Q28241157 | ||
| Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation | Q28242943 | ||
| Hedgehog signaling and the Gli code in stem cells, cancer, and metastases | Q28253856 | ||
| Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies | Q40381941 | ||
| Taming the beast within: resveratrol suppresses colitis and prevents colon cancer | Q40907631 | ||
| The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors | Q40949632 | ||
| Oncogenic Transcription Factors in the Human Acute Leukemias | Q41628889 | ||
| The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling | Q41888008 | ||
| BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK | Q42325847 | ||
| beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer | Q42794991 | ||
| The many ways to open the gate to colon cancer. | Q43170533 | ||
| Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling | Q43253904 | ||
| Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia | Q43708535 | ||
| Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer | Q43749016 | ||
| Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. | Q45345221 | ||
| Wnts as essential growth factors for the adult small intestine and colon. | Q45978930 | ||
| Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer | Q46367561 | ||
| Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas | Q47739116 | ||
| Interaction between Wingless and Notch signaling pathways mediated by dishevelled | Q50319776 | ||
| Hedgehog to Hes1: the heist of a Notch target | Q51737915 | ||
| Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression | Q51970595 | ||
| Linear model of colon cancer initiation | Q52005082 | ||
| Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis | Q54517954 | ||
| Colorectal cancer | Q55924124 | ||
| SMAD4 as a Prognostic Marker in Colorectal Cancer | Q57567752 | ||
| Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells | Q74130209 | ||
| Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis | Q77787482 | ||
| Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta | Q81284861 | ||
| Molecular Genetics of Colorectal Cancer | Q82521439 | ||
| BMP signaling promotes the growth of primary human colon carcinomas in vivo | Q82555924 | ||
| Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm | Q39386631 | ||
| Wnt and Kras signaling-dark siblings in lung cancer | Q39507181 | ||
| Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. | Q39514897 | ||
| Activation of the PI3K/Akt Pathway Mediates Bone Morphogenetic Protein 2-Induced Invasion of Pancreatic Cancer Cells Panc-1 | Q39654840 | ||
| gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity | Q39894711 | ||
| BMP suppresses PTEN expression via RAS/ERK signaling | Q40039943 | ||
| Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway | Q28505373 | ||
| Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity | Q28592781 | ||
| Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors | Q28640916 | ||
| Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells | Q29614268 | ||
| Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia | Q29614269 | ||
| Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 | Q29614651 | ||
| The mutational landscape of head and neck squamous cell carcinoma | Q29614654 | ||
| Notch1 functions as a tumor suppressor in mouse skin | Q29614987 | ||
| The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis | Q29616121 | ||
| Linking colorectal cancer to Wnt signaling | Q29619810 | ||
| Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex | Q31038919 | ||
| Wnt breakers in colon cancer | Q33197185 | ||
| ALDH+ tumor‐initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ‐secretase inhibitor and irinotecan in colorectal cancer | Q33662919 | ||
| Notch: Architect, Landscaper, and Guardian of the Intestine | Q33730198 | ||
| Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells | Q33831060 | ||
| Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. | Q33874338 | ||
| Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin. | Q34083378 | ||
| Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer | Q34193222 | ||
| Chromosome missegregation causes colon cancer by APC loss of heterozygosity | Q34239366 | ||
| Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor | Q34258285 | ||
| Glycosylation regulates Notch signalling. | Q34271410 | ||
| Three decades of Wnts: a personal perspective on how a scientific field developed | Q34276643 | ||
| Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer | Q34418424 | ||
| TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility | Q34713446 | ||
| The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers | Q34777913 | ||
| More complicated than it looks: assembly of Notch pathway transcription complexes | Q34817647 | ||
| Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins | Q34838458 | ||
| A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. | Q34978382 | ||
| Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas | Q35004950 | ||
| Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome | Q35184597 | ||
| Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence | Q35208201 | ||
| Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma | Q35471421 | ||
| The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer | Q35640296 | ||
| Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health | Q35679353 | ||
| A phase II study of RO4929097 in metastatic colorectal cancer | Q35910545 | ||
| Unexpected Hedgehog-Wnt interactions in epithelial differentiation | Q35965108 | ||
| Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors | Q36024095 | ||
| Wnt and calcium signaling: beta-catenin-independent pathways | Q36228742 | ||
| Regulation of Notch signaling by glycosylation | Q36276095 | ||
| Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease | Q36281413 | ||
| Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles | Q36366728 | ||
| Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. | Q36528951 | ||
| The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. | Q36632589 | ||
| Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | Q36646826 | ||
| Notch, Myc and breast cancer | Q36748088 | ||
| Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice | Q36869970 | ||
| Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. | Q37158058 | ||
| Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer | Q37158989 | ||
| Bone morphogenetic protein signalling in colorectal cancer. | Q37255754 | ||
| The many facets of Notch ligands | Q37256458 | ||
| Activation of Notch signaling in human colon adenocarcinoma | Q37337420 | ||
| Controversies in cancer stem cells: targeting embryonic signaling pathways | Q37552660 | ||
| Paracrine Hedgehog signaling in cancer | Q37564811 | ||
| Protecting the hedgerow: p53 and hedgehog pathway interactions | Q37676778 | ||
| Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes | Q37762393 | ||
| Recently identified and potential targets for colon cancer treatment. | Q37763104 | ||
| Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways | Q37820099 | ||
| Molecular identification and targeting of colorectal cancer stem cells | Q37839545 | ||
| Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells | Q37840943 | ||
| Notch signalling in solid tumours: a little bit of everything but not all the time | Q37867484 | ||
| Microenvironmental regulation of stem cells in intestinal homeostasis and cancer | Q37890251 | ||
| Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse. | Q37899970 | ||
| Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. | Q37906474 | ||
| Role of Notch signaling in colon homeostasis and carcinogenesis | Q37908176 | ||
| Notch signaling: simplicity in design, versatility in function | Q37914480 | ||
| Wnt signaling and colon tumorigenesis--a view from the periphery | Q37925164 | ||
| Colorectal Cancer Stem Cells | Q37974613 | ||
| Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway | Q37993742 | ||
| Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors | Q38003345 | ||
| Colon cancer stem cells – From basic to clinical application | Q38005849 | ||
| Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis | Q38308641 | ||
| Notch post-translationally regulates β-catenin protein in stem and progenitor cells | Q38635489 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | colon cancer | Q18555025 |
| P1104 | number of pages | 8 | |
| P304 | page(s) | 4344-4351 | |
| P577 | publication date | 2012-10-03 | |
| P1433 | published in | Cell Cycle | Q1254166 |
| P1476 | title | Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch | |
| P478 | volume | 11 |
| Q57498216 | A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics |
| Q28512564 | Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration |
| Q37553824 | Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells |
| Q49387038 | Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity |
| Q41674676 | Arsenic Trioxide Induces Apoptosis via Specific Signaling Pathways in HT-29 Colon Cancer Cells |
| Q35853244 | Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity |
| Q38831476 | BMP10 inhibited the growth and migration of gastric cancer cells |
| Q92366620 | BMP9 mediates the anticancer activity of evodiamine through HIF‑1α/p53 in human colon cancer cells |
| Q55070865 | Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. |
| Q34000694 | Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells |
| Q42838383 | Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells |
| Q36515055 | CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer |
| Q35591995 | Can we safely target the WNT pathway? |
| Q36210924 | Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors. |
| Q92509298 | Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types |
| Q52371987 | Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. |
| Q38961042 | Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways. |
| Q92017414 | DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways |
| Q41899030 | Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell |
| Q57493780 | Downregulation of Activin A Receptor Type 2A Is Associated with Metastatic Potential and Poor Prognosis of Colon Cancer |
| Q36299749 | Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth |
| Q26859634 | Emerging roles of PDGF-D in EMT progression during tumorigenesis |
| Q34599172 | Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma |
| Q36216202 | FOXQ1 mediates the crosstalk between TGF-β and Wnt signaling pathways in the progression of colorectal cancer |
| Q57919580 | Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer |
| Q40922383 | Favourable effects of grape seed extract on intestinal epithelial differentiation and barrier function in IL10-deficient mice |
| Q89701153 | GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway |
| Q37450330 | GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment |
| Q58608869 | Gene set enrichment analysis of the bronchial epithelium implicates contribution of cell cycle and tissue repair processes in equine asthma |
| Q35416653 | Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells. |
| Q33884437 | Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy |
| Q92668709 | Identification of Transcriptional Signatures of Colon Tumor Stroma by a Meta-Analysis |
| Q93066044 | Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells |
| Q90245125 | In vivo Bioluminescence-Based Monitoring of Liver Metastases from Colorectal Cancer: An Experimental Model |
| Q37260274 | Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients |
| Q40018531 | Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis. |
| Q37407130 | Inhibition of cell proliferation and tumor growth of colorectal cancer by inhibitors of Wnt and Notch signaling pathways |
| Q33614335 | Interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer |
| Q37668355 | Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway |
| Q39203809 | MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines |
| Q35871650 | Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers |
| Q34626101 | Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer |
| Q39227540 | Niclosamide: Beyond an antihelminthic drug |
| Q38882123 | Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer |
| Q26787087 | Novel agents for advanced pancreatic cancer |
| Q28066915 | Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad |
| Q91857038 | OTX1 and OTX2 Genes in Medulloblastoma |
| Q38670621 | Oleic Acid Uptake Reveals the Rescued Enterocyte Phenotype of Colon Cancer Caco-2 by HT29-MTX Cells in Co-Culture Mode |
| Q38221662 | Oncogenic role and therapeutic target of leptin signaling in colorectal cancer |
| Q46275904 | Osteogenic differentiation potential of adipose-derived stem cells from ovariectomized mice |
| Q91676746 | PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness |
| Q35955331 | Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer. |
| Q38390837 | Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis |
| Q33721304 | Retracted: Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix |
| Q49885029 | SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. |
| Q34458644 | SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features |
| Q38947301 | SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma |
| Q47591912 | Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway |
| Q91897235 | Signaling pathways involved in colorectal cancer progression |
| Q38244794 | Sonic hedgehog signaling in Basal cell nevus syndrome |
| Q35531884 | Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. |
| Q36343320 | TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer |
| Q47393972 | Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets |
| Q36253804 | Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors |
| Q64939186 | Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT). |
| Q41049648 | The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β |
| Q41694131 | The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy. |
| Q38564689 | The Notch pathway in colorectal cancer |
| Q21129294 | The notch ligand JAGGED1 as a target for anti-tumor therapy |
| Q35075849 | The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways |
| Q61811129 | Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk |
| Q27023599 | Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer |
| Q37556720 | XTalkDB: a database of signaling pathway crosstalk |
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