Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo

scientific article published on 07 November 2018

Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E18-09-0558
P932PMC publication ID6337912
P698PubMed publication ID30403560

P50authorMatthew John TyskaQ90406485
P2093author name stringBryan A Millis
James J Faust
Evan S Krystofiak
Suli Mao
Julia A Pinette
P2860cites workA defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1CQ24290185
Proteomic analysis of the enterocyte brush borderQ24293478
Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesionQ24294411
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmoninQ24294773
Myosin-X is a molecular motor that functions in filopodia formationQ24299253
Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferationQ24301451
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundleQ24337137
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactionsQ24538474
Review series: The cell biology of hearingQ24601353
Conserved expression of vertebrate microvillar gene homologs in choanocytes of freshwater spongesQ27323200
Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23Q27654205
The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteinsQ27659663
Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link ComplexQ27703731
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growthQ28511852
Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant miceQ28512445
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransductionQ28569812
Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1DQ28589238
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cellsQ28592402
Interactions in the network of Usher syndrome type 1 proteinsQ28592874
Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.Q30352521
Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.Q30355977
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipidsQ30479852
Myosin X transports Mena/VASP to the tip of filopodia.Q31065358
A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C geneQ33916587
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
Shaping the intestinal brush borderQ34566715
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cellsQ34680349
EUCOMM--the European conditional mouse mutagenesis program.Q34707596
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoidsQ36542776
MyTH4-FERM myosins have an ancient and conserved role in filopod formationQ37515120
Plasticity of the brush border - the yin and yang of intestinal homeostasisQ38720389
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiationQ39038189
Galectin-1 and Galectin-3 Mediate Protocadherin-24-Dependent Membrane Localization of β-catenin in Colon Cancer Cell Line HCT116Q39250900
Cadherin 23 is a component of the tip link in hair-cell stereociliaQ40571247
Myosin 7 and its adaptors link cadherins to actin.Q40984886
PCDH24-induced contact inhibition involves downregulation of beta-catenin signalingQ41130183
Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion ComplexQ42365129
Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.Q43058873
Tissue-specific and inducible Cre-mediated recombination in the gut epitheliumQ44999476
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's DiseaseQ57098797
A role for myosin VII in dynamic cell adhesionQ73670214
CEACAM1 isoforms with different cytoplasmic domains show different localization, organization and adhesive properties in polarized epithelial cellsQ77743895
The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15Q79810543
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair CellsQ91107006
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)108-118
P577publication date2018-11-07
P1433published inMolecular Biology of the CellQ2338259
P1476titleBrush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo
P478volume30

Reverse relations

cites work (P2860)
Q92475582PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli
Q90403993Understanding optical reflectance contrast for real-time characterization of epithelial precursor lesions

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