| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Giovanni Morrone | Q57560213 |
| Bruna Codispoti | Q58368192 | ||
| P2093 | author name string | Emanuela Chiarella | |
| Heather M Bond | |||
| Maria Mesuraca | |||
| Stefania Scicchitano | |||
| Nicola Amodio | |||
| Annamaria Aloisio | |||
| Valeria Lucchino | |||
| Ylenia Montalcini | |||
| P2860 | cites work | Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer | Q58420389 |
| Gene Editing on Center Stage | Q64389443 | ||
| Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1 | Q78835129 | ||
| Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice | Q24647139 | ||
| ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies | Q26770729 | ||
| Potent inhibition of DOT1L as treatment of MLL-fusion leukemia | Q27678800 | ||
| Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell | Q27861001 | ||
| 'Acute myeloid leukemia: a comprehensive review and 2016 update' | Q28072539 | ||
| A cell initiating human acute myeloid leukaemia after transplantation into SCID mice | Q28131777 | ||
| NUP98 dysregulation in myeloid leukemogenesis | Q28298423 | ||
| Modeling the initiation and progression of human acute leukemia in mice | Q28299641 | ||
| In Vitro Transformation of Primary Human CD34+ Cells by AML Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target in AML | Q28475341 | ||
| Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis | Q29614337 | ||
| Imaging hematopoietic precursor division in real time | Q30481466 | ||
| Niche-based screening identifies small-molecule inhibitors of leukemia stem cells | Q33563509 | ||
| Lentiviruses as gene delivery vectors | Q33744870 | ||
| Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. | Q33887064 | ||
| The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis | Q33891131 | ||
| A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells | Q34046864 | ||
| A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 | Q34064832 | ||
| MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment. | Q34113855 | ||
| Molecular genetics of acute myeloid leukaemia | Q34252834 | ||
| Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia | Q50453702 | ||
| Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. | Q50477441 | ||
| Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. | Q51019136 | ||
| Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila. | Q51330394 | ||
| Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model. | Q51353105 | ||
| RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. | Q52609735 | ||
| Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells. | Q53335435 | ||
| Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia. | Q55433291 | ||
| Hematopoietic stem cells: concepts, definitions, and the new reality. | Q38374442 | ||
| FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions | Q38675400 | ||
| The MLL recombinome of acute leukemias in 2017. | Q38681972 | ||
| ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells. | Q38700338 | ||
| Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches | Q38812262 | ||
| Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies | Q38905682 | ||
| DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells | Q38978245 | ||
| Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death | Q39159284 | ||
| The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis. | Q39195622 | ||
| Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia | Q39253931 | ||
| Retrovirus-mediated gene transfer into hematopoietic stem cells. | Q39696578 | ||
| Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells. | Q39874440 | ||
| Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis | Q39988310 | ||
| Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells. | Q40077330 | ||
| CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo | Q40188620 | ||
| Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. | Q40219637 | ||
| Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. | Q40252270 | ||
| FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model | Q40760923 | ||
| The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells | Q40760939 | ||
| Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein | Q41019073 | ||
| Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels | Q41896132 | ||
| ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia. | Q42265722 | ||
| Targeting leukemia stem cells: in vitro veritas? | Q42335545 | ||
| Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. | Q42374469 | ||
| A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells. | Q42728666 | ||
| TALEs of genome targeting | Q43903716 | ||
| Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis | Q44970345 | ||
| MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny. | Q45800076 | ||
| Efficient transcriptional targeting of human hematopoietic stem cells and blood cell lineages by lentiviral vectors containing the regulatory element of the Wiskott-Aldrich syndrome gene | Q45888707 | ||
| NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis | Q46550111 | ||
| BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. | Q47155915 | ||
| Preparation of 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives and their activity against DOT1L. | Q47627504 | ||
| Transcriptional memory of cells of origin overrides β-catenin requirement of MLL cancer stem cells | Q47696737 | ||
| NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice | Q34271495 | ||
| CRISPR/Cas9 for genome editing: progress, implications and challenges. | Q34411191 | ||
| Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation | Q34592792 | ||
| Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells. | Q34633547 | ||
| Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors | Q34641731 | ||
| An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes | Q34733709 | ||
| Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. | Q35001583 | ||
| Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. | Q35018755 | ||
| DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis | Q35083276 | ||
| Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program | Q35183855 | ||
| UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors. | Q35515230 | ||
| Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia | Q35553586 | ||
| Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions | Q35750567 | ||
| Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells | Q35767483 | ||
| MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. | Q35898171 | ||
| The molecular basis of leukemia | Q35961770 | ||
| MLL leukemia induction by genome editing of human CD34+ hematopoietic cells | Q36115756 | ||
| Converging pathways in leukemogenesis and stem cell self-renewal | Q36166855 | ||
| Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia | Q36223356 | ||
| Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation | Q36402468 | ||
| MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia | Q36437006 | ||
| Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia | Q36673042 | ||
| Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells | Q36726183 | ||
| Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia | Q36793806 | ||
| miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. | Q37010564 | ||
| HOXA9 is required for survival in human MLL-rearranged acute leukemias | Q37129652 | ||
| Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesis | Q37139575 | ||
| Deregulation of signaling pathways in acute myeloid leukemia | Q37240553 | ||
| Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity | Q37410557 | ||
| The molecular signature of oncofusion proteins in acute myeloid leukemia. | Q37730254 | ||
| Physiological and tissue-specific vectors for treatment of inherited diseases | Q37801839 | ||
| Recent advances in acute myeloid leukemia stem cell biology | Q38003359 | ||
| The role of HOX genes in normal hematopoiesis and acute leukemia. | Q38065068 | ||
| Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair | Q38347126 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | acute myeloid leukemia | Q264118 |
| cell | Q7868 | ||
| gene editing | Q65363531 | ||
| biomedical investigative technique | Q66648976 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 2060 | |
| P577 | publication date | 2018-08-17 | |
| P1433 | published in | Molecules | Q151332 |
| P1476 | title | Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches | |
| P478 | volume | 23 |
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