Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains

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Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains is …
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P356DOI10.3389/FNCEL.2018.00273
P932PMC publication ID6121065
P698PubMed publication ID30210299

P2093author name stringJean-Luc Gaiarsa
Christophe Porcher
Igor Medina
P2860cites workBDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusionQ24673062
Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylationQ28216152
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillationsQ28252805
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturationQ28296169
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Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy modelQ30487459
Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.Q30497503
BDNF and epilepsy: too much of a good thing?Q31865271
Mechanism of GABAB receptor-induced BDNF secretion and promotion of GABAA receptor membrane expression.Q54618524
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.Q55044608
Early Growth Response 4 Mediates BDNF Induction of Potassium Chloride Cotransporter 2 TranscriptionQ58042977
Brain-derived neurotrophic factor delays hippocampal kindling in the ratQ73088675
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neuronsQ73119677
Functional regulation of gamma-aminobutyric acid transporters by direct tyrosine phosphorylationQ73804965
Utilization of magnetoencephalography results to obtain favourable outcomes in epilepsy surgeryQ81056810
KCC2 was downregulated in small neurons localized in epileptogenic human focal cortical dysplasiaQ83266663
CREB-Dependent Regulation of GAD65 Transcription by BDNF/TrkB in Cortical InterneuronsQ84805702
Giant synaptic potentials in immature rat CA3 hippocampal neuronesQ51749893
Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopyQ51980100
GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitroQ52206835
Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesisQ33861822
Brain-derived neurotrophic factor and the development of structural neuronal connectivityQ33946881
GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition.Q33948016
Brain-derived neurotrophic factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cellsQ33997720
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.Q34039804
Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neuronsQ34143009
On the origin of interictal activity in human temporal lobe epilepsy in vitro.Q34159227
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic painQ34224419
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.Q34320496
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Neurotrophin action on a rapid timescaleQ34355606
ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neuronsQ34374013
The yin and yang of neurotrophin actionQ34439423
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibitionQ34889693
GABAergic dysfunction in mood disorders.Q35187929
Emerging themes in GABAergic synapse developmentQ35195064
Abnormal subcellular localization of GABAA receptor subunits in schizophrenia brainQ36043305
The multiple facets of gamma-aminobutyric acid dysfunction in epilepsyQ36080331
Altered Balance of Proteolytic Isoforms of Pro-Brain-Derived Neurotrophic Factor in AutismQ36164551
Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellumQ36527261
NMDA-dependent switch of proBDNF actions on developing GABAergic synapsesQ36736919
Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage MachineryQ36747217
Control of extracellular cleavage of ProBDNF by high frequency neuronal activityQ37078964
Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex.Q37153748
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activationQ37198498
Neuronal release of proBDNF.Q37331919
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndromeQ37469694
Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update.Q37518260
Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARsQ37543141
GABA(A) receptors, gephyrin and homeostatic synaptic plasticity.Q37596772
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.Q37602560
Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and diseaseQ37699047
GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems.Q37739239
Contribution of metabotropic GABAB receptors to neuronal network constructionQ37896245
Regulation of GABAARs by phosphorylationQ38323692
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neuronsQ38810200
Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.Q38834105
Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsyQ38984830
Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytesQ39241971
GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortexQ40097657
ERK/MAPK pathway regulates GABAA receptors.Q40225136
Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor functionQ42703429
proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampusQ42763307
Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neuronsQ42772124
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injuryQ43146807
BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathwayQ43169237
GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.Q43275671
BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expressionQ43572473
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.Q44316993
The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neuronsQ44364035
Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanismsQ44364044
Membrane potential of CA3 hippocampal pyramidal cells during postnatal development.Q44516285
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampusQ44776717
Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus.Q45022907
GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses.Q46294257
Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortexQ46387401
Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB.Q46437247
Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neuronsQ46506110
Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus.Q46549235
Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminalsQ46551737
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury inductionQ46568511
Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening.Q46979980
Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrusQ47035951
Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapsesQ47227298
Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling modelQ47248928
Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signalingQ47710533
Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptorsQ47805851
Spontaneous Activity Drives Local Synaptic Plasticity In Vivo.Q48078202
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.Q48094170
Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophreniaQ48128316
Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse modelQ48139290
proBDNF is a major product of bdnf gene expressed in the perinatal rat cortexQ48143000
Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.Q48156375
p75NTR immunoreactivity in the rat dentate gyrus is mostly within presynaptic profiles but is also found in some astrocytic and postsynaptic profilesQ48230056
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.Q48272472
Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.Q48278664
Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsyQ48281303
Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical developmentQ48317561
Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsyQ48363293
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic SeizuresQ48408039
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesisQ48698715
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticusQ48912671
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)273
P577publication date2018-01-01
P1433published inFrontiers in Cellular NeuroscienceQ2131509
P1476titleMechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains
P478volume12

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cites work (P2860)
Q91899527Characterization of the SIM-A9 cell line as a model of activated microglia in the context of neuropathic pain
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Q89576661Genetic and molecular basis of epilepsy-related cognitive dysfunction
Q64062979Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity
Q92970417Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial
Q61811448Pyramidal neuron growth and increased hippocampal volume during labor and birth in autism
Q95270119Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus
Q95269768The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins

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