ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

scientific article published in Nature Communications

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.3349L
P356DOI10.1038/S41467-018-05559-W
P932PMC publication ID6105683
P698PubMed publication ID30135424

P50authorShu HongbingQ9330212
Jin WeiQ86077600
P2093author name stringShu Li
Qing Yang
Wen Ye
Cao-Qi Lei
Yu-Zhi Fu
Huan Lian
Ru Zang
Ming-Ming Hu
Wei-Wei Luo
Xia-Nan Zhang
Yun-Da Chen
P2860cites workMitochondrial DNA stress primes the antiviral innate immune responseQ23030015
IFI16 is an innate immune sensor for intracellular DNAQ24301720
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerizationQ24310014
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateQ24315639
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activationQ24316038
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayQ24317317
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseQ24317784
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCQ24319706
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cellsQ24616649
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate ImmunityQ27678294
Structural mechanism of cytosolic DNA sensing by cGASQ27678393
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationQ27680866
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation LoopQ27681456
Pathogen recognition and innate immunityQ27861084
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityQ28509328
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infectionQ28594149
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Recognition of microorganisms and activation of the immune responseQ29617903
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunityQ33830730
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Q34084866
STING recognition of cytoplasmic DNA instigates cellular defenseQ34332186
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGQ34346633
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retrovirusesQ34362864
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effectsQ34367481
The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.Q34387350
Improved vectors and genome-wide libraries for CRISPR screeningQ35215629
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate AutophagyQ35738682
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.Q35854630
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cellsQ36371359
Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral responseQ36913335
Immune sensing of DNAQ38109307
Post-transcriptional regulation of gene expression in innate immunity.Q38214041
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascadeQ39066391
Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.Q39235226
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral ImmunityQ40354342
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.Q40610046
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosisQ41116868
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infectionQ41456346
Adding to the STING.Q42176514
The STING in the tail for cytosolic DNA-dependent activation of IRF3.Q44030221
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA laddersQ47809287
SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes.Q49587893
STING-dependent signaling.Q54558364
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectgeneral chemistryQ909510
detection of virusQ14866210
Zinc finger CCHC-type containing 3Q21124773
Zinc finger, CCHC domain containing 3Q29530333
P304page(s)3349
P577publication date2018-08-22
P1433published inNature CommunicationsQ573880
P1476titleZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
P478volume9

Reverse relations

cites work (P2860)
Q92657683African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway
Q92267263DNA sensing by the cGAS-STING pathway in health and disease
Q104064376DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
Q92157207Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response
Q97553625Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Q59350202Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
Q91890873Intracellular sensing of viral genomes and viral evasion
Q94948733PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA
Q94464897Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
Q94921871Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
Q59791271STING-dependent sensing of self-DNA drives silica-induced lung inflammation
Q99624196Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
Q66679242The Commensal Microbiota and Viral Infection: A Comprehensive Review
Q91637666The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage
Q92460972The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding
Q90656017Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
Q83500371USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
Q90057880ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3

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