Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS is …
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P356DOI10.1016/J.CELS.2018.10.010
P932PMC publication ID6310102
P698PubMed publication ID30471916

P2093author name stringIleana M Cristea
Joel D Federspiel
Timothy Howard
Benjamin A Diner
Krystal K Lum
Bokai Song
P2860cites workMolecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetaseQ22008036
Mitochondrial DNA stress primes the antiviral innate immune responseQ23030015
Viral apoptosis is induced by IRF-3-mediated activation of BaxQ24305369
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domainQ24324885
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scoredQ24607390
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationQ27680866
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation LoopQ27681456
Fiji: an open-source platform for biological-image analysisQ27860912
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseasesQ28082381
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAQ28118718
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunityQ28504520
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The Association of OASL and Type I Interferons in the Pathogenesis and Survival of Intracellular Replicating Bacterial SpeciesQ33707052
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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunityQ33830730
Suppression of proinflammatory cytokine expression by herpes simplex virus type 1.Q34152457
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 proteinQ34303188
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGQ34346633
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retrovirusesQ34362864
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effectsQ34367481
Fluorescent proteins as proteomic probes.Q34450046
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infectionQ34469746
Improved vectors and genome-wide libraries for CRISPR screeningQ35215629
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.Q35854630
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived CellsQ35983493
Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 ImmunosuppressionQ36040364
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion ProteinQ36052710
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.Q36068800
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing PathwayQ36167271
PANTHER version 10: expanded protein families and functions, and analysis tools.Q36434795
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon productionQ36448944
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGASQ36646579
A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral responseQ36935302
Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP.Q37123477
Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus InfectionQ37417352
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responsesQ37632327
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acidsQ38230646
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.Q38873923
Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) InfectionQ38971182
The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessibleQ39125771
OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.Q39193091
Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3.Q39596309
HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune ResponseQ40120999
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus InfectionQ40287141
TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.Q40528170
The R1 subunit of herpes simplex virus ribonucleotide reductase protects cells against apoptosis at, or upstream of, caspase-8 activationQ40695903
ICP0 gene expression is a herpes simplex virus type 1 apoptotic triggerQ41495440
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensorQ42212383
miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS.Q42515296
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.Q49223631
The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.Q52803195
NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune ActivationQ57025312
Statistical Analysis of Membrane Proteome Expression Changes inSaccharomycescerevisiaeQ57997776
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune responseQ58721729
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral ReplicationQ58795407
P4510describes a project that usesImageJQ1659584
CytoscapeQ3699942
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)627-642.e6
P577publication date2018-11-12
P1433published inCell SystemsQ27726426
P1476titleInteractome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
P478volume7