The Effect of Lutein on Eye and Extra-Eye Health

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The Effect of Lutein on Eye and Extra-Eye Health is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/NU10091321
P932PMC publication ID6164534
P698PubMed publication ID30231532

P50authorDavide CorleoQ88840054
Giulio MarchesiniQ46865234
Silvio BuscemiQ57027192
P2093author name stringFrancesco Di Pace
Maria Letizia Petroni
Angela Satriano
P2860cites workEffects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention StudyQ73570510
Factors influencing the uptake and absorption of carotenoidsQ74597530
Retinopathy of prematurityQ79858093
Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled studyQ80187947
Effects of orlistat therapy on plasma concentrations of oxygenated and hydrocarbon carotenoidsQ80815600
Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cellsQ81073258
The impact of macular pigment augmentation on visual performance in normal subjects: COMPASSQ83211085
Effect of 1-year lutein supplementation on macular pigment optical density and visual functionQ84785294
Changes following supplementation with lutein and zeaxanthin in retinal function in eyes with early age-related macular degeneration: a randomised, double-blind, placebo-controlled trialQ85324652
Lutein supplementation reduces plasma lipid peroxidation and C-reactive protein in healthy nonsmokersQ86093278
A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrastQ86174589
Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty AcidsQ86999466
Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of luteinQ95558842
Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973.Q50268024
Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study.Q50268928
Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet.Q50509680
A one year study of the macular pigment: the effect of 140 days of a lutein supplement.Q50527829
Lutein exerts anti-inflammatory effects in patients with coronary artery disease.Q50634273
Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults.Q50704945
Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy.Q50711543
Lutein and atherosclerosis: Belfast versus Toulouse revisited.Q50991353
Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities.Q50997537
An ecological study of diet and lung cancer in the South Pacific.Q51210566
Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model.Q51280858
Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures.Q51365987
Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men.Q51528598
Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta).Q51713948
The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans.Q52533936
A mitochondrial enzyme degrades carotenoids and protects against oxidative stressQ24308718
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Q24544001
Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysisQ24569500
Dietary sources of lutein and zeaxanthin carotenoids and their role in eye healthQ24602331
Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) studyQ24619709
Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoidsQ27001195
Location of macular xanthophylls in the most vulnerable regions of photoreceptor outer-segment membranesQ27690643
Macular pigment in retinal health and diseaseQ28072398
TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMDQ28219450
Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular DegenerationQ28290149
Association between intake of antioxidants and pancreatic cancer risk: a meta-analysisQ30249222
Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trialQ30457640
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular diseaseQ30693939
Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye.Q31951685
Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289].Q33246037
Inflammation and its resolution as determinants of acute coronary syndromesQ33834800
Markers of lutein and zeaxanthin status in two age groups of men and women: dietary intake, serum concentrations, lipid profile and macular pigment optical densityQ33847241
Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye StudyQ33860147
Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisisQ33864925
A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US womenQ33875244
A prospective study of carotenoid intake and risk of cataract extraction in US men.Q33875247
Nutritional modulation of cataractQ33900780
Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndromeQ33953350
Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial).Q33977885
Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein estersQ34213525
Lutein: more than just a filter for blue lightQ34215851
Antioxidant and prooxidant properties of carotenoidsQ34255896
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study GroupQ34323879
Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4.Q34343037
Stereochemistry of the human macular carotenoids.Q34364881
Absorption, metabolism, and transport of carotenoids.Q40981969
Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumQ40991007
Association of carotenoids with risk of gastric cancer: A meta-analysisQ41333520
Lutein prevents high fat diet-induced atherosclerosis in ApoE-deficient mice by inhibiting NADPH oxidase and increasing PPAR expressionQ41462386
Lutein intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R StudyQ41472302
The association between maternal antioxidant levels in midpregnancy and preeclampsiaQ41543405
Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention StudyQ41654781
Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degenerationQ41845904
Association between Dietary Carotenoid Intake and Bone Mineral Density in Korean Adults Aged 30-75 Years Using Data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (2008-2011).Q42368258
Lycopene, lutein and beta-carotene as determinants of LDL conjugated dienes in serumQ43246600
A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study.Q43604478
Macular pigments lutein and zeaxanthin as blue light filters studied in liposomesQ43661761
Plasma antioxidant vitamins and carotenoids and age-related cataractQ43802240
Lung function in relation to intake of carotenoids and other antioxidant vitamins in a population-based studyQ43897949
A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses.Q43932904
Effects of lutein supplement on serum inflammatory cytokines, ApoE and lipid profiles in early atherosclerosis population.Q43988813
Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish populationQ44097855
Lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controlled studyQ44177027
Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot studyQ44266631
Lutein administration to pregnant women with gestational diabetes mellitus is associated to a decrease of oxidative stress in newbornsQ44774121
Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women.Q44798823
Dietary intake of phytonutrients in relation to fruit and vegetable consumption in KoreaQ44855703
Carotenoid, tocopherol, and retinol concentrations in elderly human brain.Q44885353
Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA StudyQ44964097
Role of topical and nutritional supplement to modify the oxidative stressQ45094706
Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment projectQ45163501
The effects of a lutein-based supplement on objective and subjective measures of retinal and visual function in eyes with age-related maculopathy -- a randomised controlled trialQ45683269
Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillationQ45760754
Lutein and preterm infants with decreased concentrations of brain carotenoids.Q45904046
A 12-week lutein supplementation improves visual function in Chinese people with long-term computer display light exposure.Q45935436
A lutein-enriched diet prevents cholesterol accumulation and decreases oxidized LDL and inflammatory cytokines in the aorta of guinea pigsQ46296910
Lutein protects against β-amyloid peptide-induced oxidative stress in cerebrovascular endothelial cells through modulation of Nrf-2 and NF-κbQ46455660
Effects of lutein on the growth and migration of bovine lens epithelial cells in vitroQ46532699
Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women.Q46568948
Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stressQ46765629
Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trialQ46815422
Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthinQ46858619
Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults.Q47098279
Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical TrialQ47253521
Lutein levels in arterial cord blood correlate with neuroprotein activin A in healthy preterm and term newborns: A trophic role for lutein?Q47382678
Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose studyQ47450113
NrF2/ARE and NF-κB pathway regulation may be the mechanism for lutein inhibition of human breast cancer cellQ47730603
Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Q47865411
Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older AdultsQ47969696
Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity.Q48128394
Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled TrialQ48201647
Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on AgingQ48251273
Focal brain injury increases activin betaA mRNA expression in hippocampal neurons.Q48636188
Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain.Q49129325
Safety assessment of lutein and zeaxanthin (Lutemax 2020): subchronic toxicity and mutagenicity studies.Q50037630
Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.Q50162479
Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancerQ36960453
Reinterpretation of the results of a pooled analysis of dietary carotenoid intake and breast cancer risk by using the interval collapsing methodQ37153567
Antioxidant micronutrients and the risk of renal cell carcinoma in the Women's Health Initiative cohortQ37364309
Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical densityQ37395594
Parahippocampal Cortex Mediates the Relationship between Lutein and Crystallized Intelligence in Healthy, Older AdultsQ37474988
Macular pigment optical density is related to cognitive function in older peopleQ37590781
Potential role of carotenoids as antioxidants in human health and diseaseQ37617691
Impact of Mediterranean diet on metabolic syndrome, cancer and longevityQ37702835
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.Q38238059
The role of complement activation in atherogenesis: the first 40 yearsQ38532361
Health Effects of Carotenoids during Pregnancy and Lactation.Q38640978
Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohortQ38740070
Cataracts.Q38752678
Role of oxidative stress and antioxidants in daily nutrition and human healthQ38981950
Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studiesQ39052197
Intracellular uptake mechanism of lutein in retinal pigment epithelial cellsQ39097831
Inducible nitric oxide synthase: Good or bad?Q39398858
Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degenerationQ39575237
Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementationQ39592849
Long-term nutrient intake and 5-year change in nuclear lens opacitiesQ39713166
Intake of lutein and zeaxanthin differ with age, sex, and ethnicityQ39843378
Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitroQ39910623
Different molecular organization of two carotenoids, lutein and zeaxanthin, in human colon epithelial cells and colon adenocarcinoma cellsQ40130752
Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial.Q40138216
Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7).Q40162872
Serum carotenoids and colorectal cancer risk: A case-control study in Guangdong, ChinaQ40163508
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohortQ40962510
Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice.Q52874644
Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study.Q52909986
Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study.Q53121765
Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration.Q53129620
IL-1 and IL-1 regulatory pathways in cancer progression and therapy.Q53179726
Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during beta-carotene supplementation in cystic fibrosis.Q54173070
IL-35, a hallmark of immune-regulation in cancer progression, chronic infections and inflammatory diseases.Q54249178
Crystalline Maculopathy Associated With High-Dose Lutein Supplementation.Q55311966
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular DiseaseQ57268055
Lutein supplementation leads to decreased soluble complement membrane attack complex sC5b-9 plasma levelsQ57337541
Some Dietary Fibers Reduce the Absorption of Carotenoids in WomenQ57419321
Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or OlderQ59325038
Age-related macular degenerationQ59446738
Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients with Age-Related Macular DegenerationQ60699438
Accelerated bone loss and increased post-fracture mortality in elderly women and menQ60728882
Serum carotenoids and tocopherols and incidence of age-related nuclear cataractQ63339742
Reducing the Genetic Risk of Age-Related Macular Degeneration With Dietary Antioxidants, Zinc, and ω-3 Fatty AcidsQ64461561
Plasma β-carotene response in humans after meals supplemented with dietary pectinQ67485554
Analysis of the macular pigment by HPLC: retinal distribution and age studyQ68367274
Preliminary identification of the human macular pigmentQ69790666
Association of carotenoids with human plasma lipoproteinsQ70650589
Effect of beta-carotene supplementation on the concentrations and distribution of carotenoids, vitamin E, vitamin A, and cholesterol in plasma lipoprotein and non-lipoprotein fractions in healthy older womenQ70993957
The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinasQ71356050
The macular pigment. II. Spatial distribution in primate retinasQ71356053
Gastric acidity influences the blood response to a beta-carotene dose in humansQ71611071
Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral dosesQ72026161
Antioxidant status and neovascular age-related macular degeneration. Eye Disease Case-Control Study GroupQ72068439
White cell telomere length and risk of premature myocardial infarctionQ73154540
Fat-soluble nutrient concentrations in different layers of human cataractous lensQ73154795
Carotenoids and colon cancerQ73386495
A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataractQ34379644
Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysisQ34399445
Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy TrialQ34405938
Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration.Q34422484
Distribution of lutein and zeaxanthin stereoisomers in the human retinaQ34428109
Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trialsQ34445588
Lutein and zeaxanthin supplementation and association with visual function in age-related macular degenerationQ34454169
Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degenerationQ34476425
Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical TrialQ34490891
Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention StudyQ34522202
The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. OverviewQ34552999
Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil.Q34555413
Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 yearQ34582050
Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized studyQ34633116
Carotenoid intake and esophageal cancer risk: a meta-analysisQ34725729
Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA studyQ34733171
Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health InitiativeQ34760523
The influence of cigarette smoking on circulating concentrations of antioxidant micronutrientsQ34904372
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysisQ34974714
The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d.Q34979785
Carotid-wall intima-media thickness and cardiovascular eventsQ35157658
Lutein has a protective effect on hepatotoxicity induced by arsenic via Nrf2 signaling.Q35169978
The role of carotenoids in the prevention of human pathologies.Q35679097
Changes in Macular Pigment Optical Density and Serum Lutein Concentration in Japanese Subjects Taking Two Different Lutein SupplementsQ35801527
Ameliorative effects of lutein on non-alcoholic fatty liver disease in ratsQ35843044
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysisQ35893064
Greater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adultsQ35932583
Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3Q36257030
The effects of lutein on respiratory health across the life course: A systematic reviewQ36377781
Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claimsQ36648521
Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.Q36676798
Prospective study of lutein/zeaxanthin intake and risk of age-related macular degenerationQ36825090
Dietary Intake of Lutein and Diabetic Retinopathy in the Atherosclerosis Risk in Communities Study (ARIC).Q36884076
Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian StudyQ36949729
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectluteinQ422067
human eyeQ430024
dietQ474191
dietary supplementQ645858
eye diseaseQ3041498
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1321
P577publication date2018-09-18
P1433published inNutrientsQ7070485
P1476titleThe Effect of Lutein on Eye and Extra-Eye Health
P478volume10

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cites work (P2860)
Q90207093Beneficial effects of vincamine with thioctic acid and lutein on retinal and optic nerve functions in an opaque media
Q91924792Carotenoids: How Effective Are They to Prevent Age-Related Diseases?
Q89477374Fruits
Q92597098Health Benefits of Nut Consumption in Middle-Aged and Elderly Population
Q90227960Narrow-Banded UVB Affects the Stability of Secondary Plant Metabolites in Kale (Brassica oleracea var. sabellica) and Pea (Pisum sativum) Leaves Being Added to Lentil Flour Fortified Bread: A Novel Approach for Producing Functional Foods
Q59130164Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

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