Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 () In Vitro

scientific article published on 31 August 2018

Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 () In Vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CELLS7090126
P932PMC publication ID6162519
P698PubMed publication ID30200301

P50authorHarald MückterQ120983472
Dirk SteinritzQ42700605
P2093author name stringHorst Thiermann
Harald John
Thomas Gudermann
Tanja Popp
Robin Lüling
P2860cites workZinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brainQ22253439
TRPA1: Acrolein meets its target.Q51101542
Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells.Q51436356
Modification of cytosolic free calcium concentrations in human keratinocytes after sulfur mustard exposure.Q52602343
TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.Q52657444
Calmodulin mediates sulfur mustard toxicity in human keratinocytes.Q53602949
Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in MiceQ57010003
Direct evidence for functional TRPV1/TRPA1 heteromersQ58791937
A GPHN point mutation leading to molybdenum cofactor deficiencyQ82271186
Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammationQ85728547
Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2Q24296406
Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activityQ24315835
macroH2A1 histone variant represses rDNA transcriptionQ24337356
Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRQ24681390
TRPA1 as a drug target--promise and challengesQ26863458
Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasuresQ27693846
Role of TRP channels in the induction of heat shock proteins (Hsps) by heating skinQ28085547
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNAQ28114829
Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammationQ28484076
Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic isletQ28572208
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1Q28581167
TRPA1 is a major oxidant sensor in murine airway sensory neuronsQ28587771
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteinesQ29615510
An introduction to TRP channelsQ29615753
Calcium, ATP, and ROS: a mitochondrial love-hate triangleQ29619742
Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathwayQ32085275
Heat shock proteins in the photobiology of human skinQ34421860
An ion channel essential for sensing chemical damage.Q34655237
Toxicology and pharmacology of the chemical warfare agent sulfur mustard.Q34734633
Chaperones in control of protein disaggregationQ34740513
Sulfur mustard induced nuclear translocation of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH).Q34799040
Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blisteringQ34995354
Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfideQ35219805
Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skinQ35516441
Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca²⁺.Q36173274
DNA interstrand crosslink repair and cancerQ36576047
Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfideQ36638914
Balancing repair and tolerance of DNA damage caused by alkylating agentsQ36651488
Molecular chaperones: multiple functions, pathologies, and potential applicationsQ36664175
DNA crosslinking damage and cancer - a tale of friend and foe.Q37127343
A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protectionQ37192704
The novel roles of four and a half LIM proteins 1 and 2 in the cardiovascular system.Q37871648
Activation of the chemosensing transient receptor potential channel A1 (TRPA1) by alkylating agentsQ38940552
Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cellsQ39101987
Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cellsQ39489213
The cell surface expressed nucleolin is a glycoprotein that triggers calcium entry into mammalian cells.Q39913449
A large-scale quantitative proteomic approach to identifying sulfur mustard-induced protein phosphorylation cascadesQ39936884
Heat shock proteins and molecular chaperones: implications for adaptive responses in the skinQ40500635
Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membraneQ41362803
DNA damage induced by alkylating agents and repair pathwaysQ41685430
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.Q41839374
The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.Q41917505
Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinocytes via a Ca2+-calmodulin and caspase-dependent pathwayQ42458192
Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cellsQ42713916
Sulphur mustard induces time- and concentration-dependent regulation of NO-synthesizing enzymesQ44402960
Microarray analysis of gene expression in murine skin exposed to sulfur mustardQ45240740
Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception.Q46252398
Early oxidative stress, DNA damage and inflammation resulting from subcutaneous injection of sulfur mustard into mice.Q46317890
Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration - effects of α-linolenic acid and N-acetylcysteineQ46884846
TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute goutQ46900003
Dawning of a new era in TRP channel structural biology by cryo-electron microscopy.Q47552061
Molecular cloning, sequence identification and tissue expression profile of three novel genes Sfxn1, Snai2 and Cno from Black-boned sheep (Ovis aries)Q48062814
N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.Q48302303
Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitroQ50052664
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)126
P577publication date2018-08-31
P1433published inCellsQ27724621
P1476titleTransient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro
P478volume7

Reverse relations

cites work (P2860)
Q98773671Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard
Q91795700Transient Receptor Potential (TRP) Channels in Health and Disease

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