Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts

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Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3324/HAEMATOL.2018.192518
P932PMC publication ID6165792
P698PubMed publication ID30076180

P50authorUlrich GermingQ71780112
Peter ValentQ56697676
P2093author name stringIgor Theurl
Hans-Peter Horny
Karl Sotlar
Rainer Oberbauer
Ulrich Jäger
Olivier Hermine
Wolfgang R Sperr
Guntram Büsche
Klaus Geissler
Richard Moriggl
Marie C Béné
Reinhard Stauder
Peter Bettelheim
Michael Pfeilstöcker
Wolfgang Füreder
Jürg Schwaller
Iris Z Uras
P2860cites workHsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1Q24336627
The human side of hypoxia-inducible factorQ24646951
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoQ24685620
Hepcidin: A Promising Therapeutic Target for Iron Disorders: A Systematic ReviewQ26750731
Erythroid burst formation in cultures of bone marrow and peripheral blood from patients with refractory anemiaQ70439559
The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stagesQ70893497
Improved method for diagnosis of polycythemia vera based on flow cytometric analysis of autonomous growth of erythroid precursors in liquid cultureQ71937860
Interleukin-10 inhibits erythropoietin-independent growth of erythroid bursts in patients with polycythemia veraQ77218342
Recombinant human erythropoietin in the anaemia of multiple myeloma and non-Hodgkin's lymphomaQ77453541
What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Q80912464
Anaemia of the elderly (AOE): does it exist and does it matter in clinical practice?Q82218002
The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70Q89777415
Flow cytometry evaluation of erythroid dysplasia in patients with myelodysplastic syndromeQ46960830
Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditionsQ47124670
Impact of genotype on leukaemic transformation in polycythaemia vera and essential thrombocythaemiaQ48100617
Bone marrow findings in blast phase of polycythemia veraQ49504954
Anemia at older age: etiologies, clinical implications and managementQ49988753
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.Q50506267
Immunophenotypic analysis of erythroid dysplasia and its diagnostic application in myelodysplastic syndromes.Q50523970
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.Q50578930
New proposals of the WHO working group (2016) for the diagnosis of myelodysplastic syndromes (MDS): Characteristics of refined MDS types.Q53189055
Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm.Q53281116
Molecular characterization of acute erythroid leukemia (M6-AML) using targeted next-generation sequencing.Q53412376
More than 1 TP53 abnormality is a dominant characteristic of pure erythroid leukemia.Q55120146
Anemia in PregnancyQ56341634
Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemiaQ57217591
Deficiency of pluripotent hemopoietic progenitor cells in myelodysplastic syndromesQ57756710
Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factorsQ26777265
How the Target Hemoglobin of Renal Anemia Should BeQ26783623
Primitive and definitive erythropoiesis in mammalsQ26851586
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modificationsQ26860339
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemiaQ27853375
Recent advances in the treatment of lower-risk non-del(5q) myelodysplastic syndromes (MDS)Q28066544
Transcriptional regulation of erythropoiesis: an affair involving multiple partnersQ28200921
Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta familyQ28203556
Identification of erythroferrone as an erythroid regulator of iron metabolismQ28240988
MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4Q28251320
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptorQ28288945
Acute erythremic myelosis (true erythroleukaemia): a variant of AML FAB-M6Q28360437
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromesQ28392451
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cellsQ28510862
Anemia in the elderly: a consequence of aging?Q30238892
Negative autoregulation by FAS mediates robust fetal erythropoiesisQ33300418
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.Q33371084
Hemolytic anemia in adults: main causes and diagnostic proceduresQ33400568
Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set pointQ33615967
Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like diseaseQ33839857
Molecular liaisons between erythropoiesis and iron metabolismQ33948684
Anemia and aging: an overview of clinical, diagnostic and biological issuesQ34238927
Transcriptional control of erythropoiesis: emerging mechanisms and principles.Q34700755
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemiaQ35127943
Emerging EPO and EPO receptor regulators and signal transducersQ35692391
Mortality risk of darbepoetin alfa versus epoetin alfa in patients with CKD: systematic review and meta-analysisQ35798280
The molecular regulation of iron metabolismQ35901908
Polycythemia vera and other primary polycythemiasQ36051872
The brain erythropoietin system and its potential for therapeutic exploitation in brain diseaseQ36455213
Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conferenceQ36719937
Erythroblastic islands: niches for erythropoiesisQ36787505
Anemia in the elderly: how should we define it, when does it matter, and what can be done?Q36900473
Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyondQ36947417
Regulation of erythropoiesis by hypoxia-inducible factorsQ37063716
Erythropoietic agents and the elderlyQ37098040
A Red Carpet for Iron Metabolism.Q39106718
Erythropoietin Regulation by Angiotensin II.Q39383729
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.Q39722840
Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone lossQ39831871
Transcription factor GATA-1 and erythroid developmentQ40870806
Studies on hematopoietic stem cells: XI. Lack of erythroid burst-forming units (BFU-E) in patients with aplastic anemiaQ41661146
Assessment of erythroid dysplasia by "difference from normal" in routine clinical flow cytometry workup.Q41711144
Cdk6 contributes to cytoskeletal stability in erythroid cells.Q41949980
Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinibQ41955541
Between subjects variability in haemoglobin and dose are not associated with the erythropoiesis-stimulating agent used to treat anaemia in dialysis: a meta-analysisQ42130626
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemiaQ42152354
Impaired formation of erythroblastic islands is associated with erythroid failure and poor prognosis in a significant proportion of patients with myelodysplastic syndromesQ42399896
Erythropoietin treatment of anemia associated with multiple myelomaQ43756412
A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of lifeQ44369408
Hematopoietic stem cell transplantation for de novo erythroleukemia: a study of the European Group for Blood and Marrow Transplantation (EBMT).Q44373728
Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristicsQ44590610
HSP70, an erythropoiesis regulator that determines the fate of erythroblasts between death and differentiationQ44907948
A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study.Q45991834
Flow cytometry evaluation of erythroid and myeloid dysplasia in patients with myelodysplastic syndrome.Q46402910
Chronic anemia and fatigue in elderly patients: results of a randomized, double-blind, placebo-controlled, crossover exploratory study with epoetin alfaQ46422375
Hepcidin regulation in the anemia of inflammationQ37193954
Current and upcoming erythropoiesis-stimulating agents, iron products, and other novel anemia medicationsQ37398124
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Regulation of hepcidin and iron-overload diseaseQ37463068
Minimal diagnostic criteria for myelodysplastic syndromes and separation from ICUS and IDUS: update and open questionsQ37488486
The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors.Q37679592
GATA factor switching during erythroid differentiationQ37705916
The role of the renin-angiotensin system in the regulation of erythropoiesisQ37733101
Erythropoiesis stimulating agents and anaemia of end-stage renal diseaseQ37742655
Advancements in anemias related to chronic conditionsQ37771336
Postpartum anemia I: definition, prevalence, causes, and consequencesQ37895161
Erythroid proliferations in myeloid neoplasmsQ37966327
Anemia and chronic kidney disease: making sense of the recent trialsQ38006040
Low blood counts: immune mediated, idiopathic, or myelodysplasia.Q38066912
How can erythropoeitin-stimulating agent use be reduced in chronic dialysis patients?: The use of iron supplementation to reduce ESA dosing in hemodialysisQ38114158
Erythropoiesis stimulating agents and other growth factors in low-risk MDS.Q38186278
New treatment approaches in chronic kidney disease-associated anaemiaQ38192002
The ESA scenario gets complex: from biosimilar epoetins to activin trapsQ38205752
Erythropoiesis: from molecular pathways to system propertiesQ38283996
An overview of molecular basis of iron metabolism regulation and the associated pathologies.Q38406652
New Treatment Approaches for the Anemia of CKD.Q38587175
Ineffective erythropoiesis and regulation of iron status in iron loading anaemiasQ38613789
Reclassifying myelodysplastic syndromes: what's where in the new WHO and why.Q38659504
Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney diseaseQ38666448
Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategiesQ38700727
Metabolic regulation of hematopoietic stem cell commitment and erythroid differentiationQ38731009
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemiaQ38759271
Pure erythroid leukemiaQ38779206
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosisQ38816577
Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.Q38831810
Efficacy and safety of darbepoetin alpha in patients with myelodysplastic syndromes: a systematic review and meta-analysisQ38841795
Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease.Q38904398
Revisiting erythroleukemiaQ39016718
Aplastic anemia and clonal evolution: germ line and somatic geneticsQ39027706
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecthematologyQ103824
anemiaQ5445
polycythemiaQ933716
neoplasmQ1216998
cellQ7868
neoplastic gene expression regulationQ66660300
P304page(s)1593-1603
P577publication date2018-10-01
P1433published inHaematologicaQ5638209
P1476titleNormal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts
P478volume103

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cites work (P2860)
Q90721263Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways
Q91686272Treatment options for anemia in the elderly
Q91292020mTORC1 activity is essential for erythropoiesis and B cell lineage commitment

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