Erythropoietic agents and the elderly

scientific article published on October 2008

Erythropoietic agents and the elderly is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1053/J.SEMINHEMATOL.2008.06.007
P932PMC publication ID2643059
P698PubMed publication ID18809098
P5875ResearchGate publication ID23272699

P2093author name stringJosef T Prchal
Neeraj Agarwal
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxiaQ24298480
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
A gain-of-function mutation in the HIF2A gene in familial erythrocytosisQ24654396
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexQ24654714
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaquesQ24684076
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Efficacy and safety of epoetin alfa in critically ill patientsQ28246281
Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cellsQ28282130
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiencyQ28297161
Acute postnatal ablation of Hif-2alpha results in anemiaQ28591898
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivoQ28594830
Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patientsQ33243661
Erythropoietin blockade inhibits the induction of tumor angiogenesis and progressionQ33288270
Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the "Health and Anemia" studyQ33326646
Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cellsQ33730124
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesQ34086191
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemiaQ34157665
HIF-1 and mechanisms of hypoxia sensingQ34180645
Pharmacologically regulated cell therapyQ34225667
Controlling Signal Transduction with Synthetic LigandsQ34306937
Erythropoietin and the nervous systemQ34309805
Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers.Q34529820
Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promiseQ34567935
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeuticsQ35075541
Expression cloning of the murine erythropoietin receptorQ35416452
Erythropoietin both protects from and reverses experimental diabetic neuropathyQ35554405
Phase II study of two dose schedules of C.E.R.A. (Continuous Erythropoietin Receptor Activator) in anemic patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapyQ35696941
Growth factor receptors as regulators of hematopoiesisQ35848814
A novel protective effect of erythropoietin in the infarcted heartQ36001255
Erythropoietin therapy for acute stroke is both safe and beneficialQ36088111
The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestationsQ36204170
CERA (Continuous Erythropoietin Receptor Activator): a new erythropoiesis-stimulating agent for the treatment of anemia.Q36289609
Regulation of angiogenesis by hypoxia-inducible factor 1.Q36485190
Erythropoietin in cancer: presumption of innocence?Q36803489
Risks and benefits of erythropoiesis-stimulating agents in cancer managementQ36881654
Erythropoietin and treatment of non-anemic conditions--cardiovascular protectionQ36881667
Novel erythropoiesis-stimulating agents: a new era in anemia managementQ37031261
Does epoetin alfa improve health-related quality of life in chronically ill patients with anemia? Summary of trials of cancer, HIV/AIDS, and chronic kidney diseaseQ37072955
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemiaQ37100060
The non-haematopoietic biological effects of erythropoietinQ37103957
Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I.Q37118171
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerizationQ37125538
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptorQ37571920
Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietinQ38294090
Human, rat, and mouse kidney cells express functional erythropoietin receptorsQ38327858
Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesisQ38333334
Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic diseaseQ38337379
Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietinQ38355642
Serum erythropoietin and aging: a longitudinal analysisQ38441591
Blood haemoglobin declines in the elderly: implications for reference intervals from age 70 to 88.Q39552802
CNTO 530: molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in miceQ40017689
The first human cell line-derived erythropoietin, epoetin-delta (Dynepo), in the management of anemia in patients with chronic kidney diseaseQ40092893
Epoetin delta, erythropoietin produced in a human cell line, in the management of anaemia in predialysis chronic kidney disease patientsQ40173236
Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia.Q40230680
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1.Q41055727
Inactivation of erythropoietin leads to defects in cardiac morphogenesisQ41679719
Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumorsQ42455621
Erythropoietin expression in primary rat Sertoli and peritubular myoid cellsQ42511877
Anemia in the elderly: a public health crisis in hematologyQ42673911
Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in cultureQ43577442
Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemiaQ43611163
Impact of anemia on mortality, cognition, and function in community-dwelling elderlyQ44030916
Pharmacologically regulated in vivo selection in a large animalQ44117631
Anemia is associated with disability and decreased physical performance and muscle strength in the elderlyQ44846134
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemiaQ44967334
Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failureQ45012602
Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathyQ46667958
Anatomical compartments modify the response of human hematopoietic cells to a mitogenic signalQ46864865
Hemoglobin levels and skeletal muscle: results from the InCHIANTI studyQ47925051
Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferationQ48119740
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.Q48421828
Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhageQ48617513
Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA).Q50672978
Hematide is immunologically distinct from erythropoietin and corrects anemia induced by antierythropoietin antibodies in a rat pure red cell aplasia model.Q50685607
Economic burden of patients with anemia in selected diseases.Q50772464
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial.Q51694824
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.Q52202995
Exploring recombinant human erythropoietin in chronic progressive multiple sclerosisQ59264385
Once-Monthly Subcutaneous C.E.R.A. Maintains Stable Hemoglobin Control in Patients with Chronic Kidney Disease on Dialysis and Converted Directly from Epoetin One to Three Times WeeklyQ61428121
Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularizationQ61965065
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridizationQ68255477
On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin actionQ68695500
Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytesQ69323711
Localization of cells producing erythropoietin in murine liver by in situ hybridizationQ70167724
Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: a mechanism for controlled rates of erythrocyte productionQ70482972
Familial PolycythemiaQ71855263
Origin and fate of erythropoietin in human milkQ73108880
The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetinQ77153488
Correction of anemia with epoetin alfa in chronic kidney diseaseQ79363020
Are erythropoietin receptors expressed in tumors? Facts and fiction--more careful studies are neededQ80242639
Does erythropoietin promote tumor growth?Q80889046
Anti-Epo receptor antibodies do not predict Epo receptor expressionQ81402534
Pharmacokinetic and pharmacodynamic properties of methoxy polyethylene glycol-epoetin beta are unaffected by the site of subcutaneous administrationQ81503582
P433issue4
P304page(s)267-275
P577publication date2008-10-01
P1433published inSeminars in HematologyQ15765535
P1476titleErythropoietic agents and the elderly
P478volume45

Reverse relations

cites work (P2860)
Q40825620Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice
Q36317698Management of anemia of inflammation in the elderly
Q58793895Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts
Q35631773Not so benign haematology: anaemia of the elderly

Search more.