The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin

scientific article published on 01 August 1998

The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJM199808273390903
P698PubMed publication ID9718377

P2093author name stringBolton WK
Nissenson AR
Schwab SJ
Goodkin DA
Egrie JC
Besarab A
Browne JK
Okamoto DM
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectheart diseaseQ190805
hemodialysis patientQ126109077
P304page(s)584-590
P577publication date1998-08-01
P1433published inThe New England Journal of MedicineQ582728
P1476titleThe effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
P478volume339

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cites work (P2860)
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Q37415688Key comorbid conditions that are predictive of survival among hemodialysis patients
Q39977619Key insights into present and future treatments of anaemia in CKD patients
Q35573726Left ventricular dysfunction in the haemodialysis population.
Q37477724Left ventricular geometry predicts cardiovascular outcomes associated with anemia correction in CKD.
Q79267929Left ventricular hypertrophy: a surrogate end point or correlate of cardiovascular events in kidney disease?
Q55266280Levocarnitine Injections Decrease the Need for Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia.
Q58561315Lipid management in patients with chronic kidney disease
Q35073857Long-term prognostic impact of the use of erythropoietic-stimulating agents in patients with chronic myeloid leukemia in chronic phase treated with imatinib
Q99710988Low rather than high mean corpuscular volume is associated with mortality in Japanese patients under hemodialysis
Q36294113Low versus high dose erythropoiesis-stimulating agents in hemodialysis patients with anemia: A randomized clinical trial.
Q35868691Low-Dose Treatment with Erythropoiesis-Stimulating Agents and Cardiovascular Geometry in Chronic Kidney Disease: Is Darbepoetin-α More Effective than Expected?
Q33898717Macrocytosis may be associated with mortality in chronic hemodialysis patients: a prospective study
Q82729789Maintenance of target hemoglobin level in stable hemodialysis patients constitutes a theoretical task: a historical prospective study
Q35735258Major declines in epoetin dosing after prospective payment system based on dialysis facility organizational status
Q36719231Management of anemia in children receiving chronic peritoneal dialysis
Q38134288Management of anemia with erythropoietic-stimulating agents in children with chronic kidney disease
Q38121827Management of neurogenic orthostatic hypotension in patients with autonomic failure
Q80863092Managing anemia in dialysis patients: hemoglobin cycling and overshoot
Q33797640Managing anemia in patients with chronic heart failure: what do we know?
Q36443751Managing cardiovascular risk in people with chronic kidney disease: a review of the evidence from randomized controlled trials
Q37157237Managing dialysis patients who develop anemia caused by chronic kidney disease: focus on peginesatide
Q55379461Measurement properties of the Short Form-36 (SF-36) and the Functional Assessment of Cancer Therapy - Anemia (FACT-An) in patients with anemia associated with chronic kidney disease.
Q33600121Mechanism of erythropoietin-induced hypertension
Q37038424Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure
Q27693202Mechanisms of anemia in CKD.
Q36600985Mechanisms of disease: erythropoietin--an old hormone with a new mission?
Q37082467Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy
Q50119222Medical safety in the care of the person with end-stage kidney disease
Q37154109Medicare's payment strategy for end-stage renal disease now embraces bundled payment and pay-for-performance to cut costs
Q36265484Medication adherence in randomized controlled trials evaluating cardiovascular or mortality outcomes in dialysis patients: A systematic review
Q84122396Mitigating the cardiovascular risk of anemia in patients with type 2 diabetes and CKD: Does darbepoetin help? The TREAT Trial
Q36482963Modulation of stroke risk in chronic kidney disease.
Q33999246Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.
Q40245317Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis
Q34306104Mortality in dialysis patients may not be associated with ESA dose: a 2-year prospective observational study
Q37397724Mortality in renal transplant recipients given erythropoietins to increase haemoglobin concentration: cohort study
Q34281518Nadir hemoglobin levels after discontinuation of epoetin in hemodialysis patients
Q34534923Naturally occurring higher hemoglobin concentration does not increase mortality among hemodialysis patients
Q36863406Negative trials in nephrology: what can we learn?
Q53335433Neurocognitive function and quality of life in relation to hematocrit levels in chronic hemodialysis patients.
Q38522683Nitric oxide in the human respiratory cycle.
Q38112049Nitric oxide transport in blood: a third gas in the respiratory cycle
Q83324452Nonhypotensive dose of beta-adrenergic blocker ameliorates capillary deficits in the hearts of rats with moderate renal failure
Q37282300Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease
Q73769750Normalization of hematocrit in hemodialysis patients does not affect silent ischemia
Q41669033Normalizing hematocrit in dialysis patients improves brain function
Q33256941Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia
Q46149455Novel techniques and innovation in blood purification: a clinical update from Kidney Disease: Improving Global Outcomes
Q55416565Obesity may be erythropoietin dose-saving in hemodialysis patients.
Q36522468Obesity paradox in end-stage kidney disease patients
Q30423049Observational studies versus randomized controlled trials: avenues to causal inference in nephrology
Q46186819Olmesartan clinical trial in Okinawan patients under OKIDS (OCTOPUS) study: design and methods
Q33392426Optimal and continuous anaemia control in a cohort of dialysis patients in Switzerland
Q88207162Optimal hematocrit based on regional cerebral blood flow in hemodialysis patients with diabetic nephropathy
Q47954573Optimal hematocrit in an artificial microvascular network
Q36061854Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients
Q91815892PIVOTAL trial: iron loading improves clinical outcomes
Q34085240Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury
Q33808512Parenteral iron use in the management of anemia in end-stage renal disease patients
Q37123216Parenteral iron use: possible contribution to exceeding target hemoglobin in hemodialysis patients
Q34713632Past, present and future of erythropoietin use in the elderly
Q33691308Patient satisfaction with in-centre haemodialysis care: an international survey
Q36733554Peginesatide for maintenance treatment of anemia in hemodialysis and nondialysis patients previously treated with darbepoetin alfa
Q35944877Performance of a Predictive Model for Long-Term Hemoglobin Response to Darbepoetin and Iron Administration in a Large Cohort of Hemodialysis Patients
Q43116165Performance variability of seven commonly used self-monitoring of blood glucose systems: clinical considerations for patients and providers
Q36860265Pharmacist's role in managing anemia in patients with chronic kidney disease: potential clinical and economic benefits
Q26829812Pharmacologic management of chronic reno-cardiac syndrome
Q38704713Pharmacological targeting of the HIF hydroxylases--A new field in medicine development
Q53383073Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China.
Q97527917Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis
Q36144411Pleiotropic renal actions of erythropoietin
Q37530419Posttransplant anemia: the role of sirolimus
Q77763078Potential cost savings of erythropoietin administration in end-stage renal disease
Q58696069Predialysis anemia management and outcomes following dialysis initiation: A retrospective cohort analysis
Q47118771Predictors of adherence to a new erythropoiesis-stimulating agent inpatient ordering policy: A cross-sectional study.
Q37214510Predictors of hyporesponsiveness to erythropoiesis-stimulating agents in hemodialysis patients
Q35685985Predictors of quality of life of hemodialysis patients in India
Q34017119Premature cardiovascular disease in chronic renal failure
Q34124684Preoperative hemoglobin and outcomes in patients with CKD undergoing cardiac surgery
Q33871590Pretransplantation erythropoiesis-stimulating agent hyporesponsiveness is associated with increased kidney allograft failure and mortality
Q50989985Pretreatment with erythropoietin attenuates the neurological injury after spinal cord ischemia.
Q34770416Prevalence of ventricular arrhythmia and its associated factors in nondialyzed chronic kidney disease patients
Q44125448Prognostic significance of left ventricular hypertrophy observed at dialysis initiation depends on the pre-dialysis use of erythropoiesis-stimulating agents
Q89521025Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia
Q30874431Protecting the confidentiality of interim data: addressing current challenges
Q35201722Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms
Q83575095Proteinuria as a surrogate end point--more data are needed
Q57282391Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data
Q34031364Randomized double-blind clinical trial of a new human epoetin versus a commercially available formula for anemia control in patients on hemodialysis
Q48225857Rational Management of Iron-Deficiency Anaemia in Inflammatory Bowel Disease
Q33890794Real-World Impact of Cardiovascular Disease and Anemia on Quality of Life and Productivity in Patients with Non-Dialysis-Dependent Chronic Kidney Disease
Q26849298Recent advances in the management of hemodialysis patients: a focus on cardiovascular disease
Q37230276Recombinant human epoetin beta in the treatment of chemotherapy-related anemia
Q36661294Recombinant human epoetin beta in the treatment of renal anemia
Q44730385Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
Q57165825Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
Q90333662Red Blood Cell Dysfunction in Critical Illness
Q30275352Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Q27021803Red cell physiology and signaling relevant to the critical care setting
Q38072533Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new.
Q37063716Regulation of erythropoiesis by hypoxia-inducible factors
Q51907157Relation between level or change of hemoglobin and generic and disease-specific quality of life measures in hemodialysis.
Q28468446Relationship between Hemoglobin Levels Corrected by Interdialytic Weight Gain and Mortality in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study
Q41733983Relationship between inflammatory cytokines and cardiorenal anemia syndrome: treatment with recombinant human erythropoietin (rhepo).
Q47111895Renal association clinical practice guideline on Anaemia of Chronic Kidney Disease
Q37200548Renal disease: a common and a silent killer
Q35151878Resistance to erythropoiesis stimulating agents in patients treated with online hemodiafiltration and ultrapure low-flux hemodialysis: results from a randomized controlled trial (CONTRAST)
Q53096541Responsiveness to erythropoiesis-stimulating agents in chronic kidney disease: does geography matter?
Q36937327Restoring invisible and abandoned trials: a call for people to publish the findings
Q37534821Review article: Biomarkers of clinical outcomes in advanced chronic kidney disease
Q41860936Role of hematopoietic growth factors as adjuncts in the treatment of chronic hepatitis C patients
Q35577092Role of vascular function in predicting arteriovenous fistula outcomes: an observational pilot study
Q64111741Roxadustat Treatment of Chronic Kidney Disease-Associated Anemia in Japanese Patients Not on Dialysis: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
Q26745888SPRINT: The Study Nephrologists Might Take With a Grain of Salt
Q33985838Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
Q73290174Serum erythropoietin in heart failure patients treated with ACE-inhibitors or AT(1) antagonists
Q35141918Short-term, high-dose pamidronate-induced acute tubular necrosis: the postulated mechanisms of bisphosphonate nephrotoxicity
Q49680628Should We Increase GFR with Bardoxolone in Alport Syndrome?
Q42931999Should glucose-sparing prescriptions be expected to reduce the cardiovascular risk of peritoneal dialysis patients?
Q31073395Should we adjust erythropoiesis-stimulating agent dosage to postdialysis hemoglobin levels? A pilot study.
Q38051056Should we reconsider iron administration based on prevailing ferritin and hepcidin concentrations?
Q37670331Sickle trait in African-American hemodialysis patients and higher erythropoiesis-stimulating agent dose
Q41123077Similar Outcomes for Two Anemia Treatment Strategies among Elderly Hemodialysis Patients with Diabetes
Q33532601Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease
Q92346724Sotatercept Safety and Effects on Hemoglobin, Bone, and Vascular Calcification
Q34493460Stable hemoglobin in hemodialysis patients: forest for the trees--a 12-week pilot observational study
Q38556990State-of-the-art biosimilar erythropoietins in the management of renal anemia: lessons learned from Europe and implications for US nephrologists
Q42593974Stimulating erythropoiesis in inflammatory bowel disease associated anemia
Q27694667Strategies for postmarketing surveillance of drugs and devices in patients with ESRD undergoing dialysis
Q41621194Successful creation of an anemia management algorithm for hemodialysis patients
Q35917499Survival in daily home hemodialysis and matched thrice-weekly in-center hemodialysis patients
Q94526892Target haemoglobin concentrations in chronic kidney disease
Q57772073Target haemoglobin concentrations in chronic kidney disease
Q44649509Target hemoglobin trials in chronic kidney disease: design and interpretation issues
Q38042223Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis
Q36315311Targets for adapting intravenous iron dose in hemodialysis: a proof of concept study
Q38091580Targets, trends, excesses, and deficiencies: refocusing clinical investigation to improve patient outcomes
Q90428600Testing two (of several) intravenous iron dosing strategies in hemodialysis
Q36687012The American Society of Nephrology at 50: A Personal Perspective
Q36073903The Cost-Effectiveness of Anemia Treatment for Persons with Chronic Kidney Disease
Q35849765The Different Association between Serum Ferritin and Mortality in Hemodialysis and Peritoneal Dialysis Patients Using Japanese Nationwide Dialysis Registry
Q57174517The Incidence and Pathophysiology of the Obesity Paradox: Should Peritoneal Dialysis and Kidney Transplant Be Offered to Patients with Obesity and End-Stage Renal Disease?
Q92921916The Influence of Inflammation on Anemia in CKD Patients
Q49168187The Kidney Disease: improving Global Outcomes website: comparison of guidelines as a tool for harmonization
Q35801832The Korean Clinical Research Center for End-Stage Renal Disease Study Validates the Association of Hemoglobin and Erythropoiesis-Stimulating Agent Dose with Mortality in Hemodialysis Patients
Q38496987The Labile Side of Iron Supplementation in CKD
Q46035828The MAINTAIN study--managing hemoglobin variability with darbepoetin alfa in dialysis patients experiencing a severe drop in hemoglobin.
Q46726047The Medicare Access and CHIP Reauthorization Act: Implications for Nephrology
Q38821770The Obesity Paradox in Kidney Disease: How to Reconcile it with Obesity Management
Q38740871The Safety of Erythropoiesis-Stimulating Agents for the Treatment of Anemia Resulting from Chronic Kidney Disease
Q61798493The association of the difference in hemoglobin levels before and after hemodialysis with the risk of 1-year mortality in patients undergoing hemodialysis. Results from a nationwide cohort study of the Japanese Renal Data Registry
Q58795386The authors' reply
Q36896011The case for intervention bias in the practice of medicine
Q37231779The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions
Q36631500The cost-utility of treating anemia with continuous erythropoietin receptor activator or Epoetin versus routine blood transfusions among chronic hemodialysis patients.
Q98177250The current and future landscape of dialysis
Q35017465The effect of altitude change on anemia treatment response in hemodialysis patients
Q36736806The effect of altitude on dosing and response to erythropoietin in ESRD
Q79837170The effect of epoetin dose on hematocrit
Q35692440The effect of high-flux hemodialysis on hemoglobin concentrations in patients with CKD: results of the MINOXIS study
Q33234889The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: rationale and study design of a randomized controlled pilot study
Q33939447The elderly patients on hemodialysis
Q36547323The epidemics of cardiovascular disease in elderly patients with chronic kidney disease--two facets of the same problem
Q38798407The future of intravenous iron in nephrology
Q37068266The greatly misunderstood erythropoietin resistance index and the case for a new responsiveness measure
Q36072666The health-related quality of life was not improved by targeting higher hemoglobin in the Normal Hematocrit Trial
Q83307973The impact of ferritin fluctuations on stable hemoglobin levels in hemodialysis patients
Q43608007The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients: a single-center cohort study
Q28194293The importance of anemia and its correction in the management of severe congestive heart failure
Q33412890The importance of iron in long-term survival of maintenance hemodialysis patients treated with epoetin-alfa and intravenous iron: analysis of 9.5 years of prospectively collected data
Q34193545The influence of Erythropoietin on platelet activation, thrombin generation and FVII/active FVII in patients with AMI.
Q51121094The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis.
Q37542851The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients
Q30446840The mortality risk associated with higher hemoglobin: is the therapy to blame?
Q35758558The new FDA labeling for ESA--implications for patients and providers
Q48422674The normal HCT trial re-revisited: what were the actual findings?
Q33646679The role of anemia management in improving outcomes for African-Americans with chronic kidney disease
Q43054143The role of platelets in atherosclerosis, diabetes mellitus, and chronic kidney disease. An attempt at explaining the TREAT study results
Q44363438The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations
Q36947417Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyond
Q39291945Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.
Q95810354Therapy insight: congestive heart failure, chronic kidney disease and anemia, the cardio-renal-anemia syndrome
Q36581425Therapy insight: management of cardiovascular disease in the renal transplant recipient
Q33348067Thrombosis in End‐Stage Renal Disease
Q83317996Time to consider the role of epoetin
Q35047211Transfusion medicine: looking to the future
Q41836951Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium.
Q36285948Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations
Q90709671Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT)
Q40540575Treatment of anemia in chronic kidney disease: known, unknown, and both
Q34064046Treatment of anemia in heart failure: potential risks and benefits of intravenous iron therapy in cardiovascular disease
Q80349184Treatment of anemia in the patient with heart failure
Q41387413Treatment of renal anemia: Erythropoiesis stimulating agents and beyond
Q34857944Trends in anemia care in older patients approaching end-stage renal disease in the United States (1995-2010).
Q35056402Trends in anemia management in US hemodialysis patients 2004-2010
Q88498966Trends in the treatment of chronic kidney disease-associated anaemia in a cohort of haemodialysis patients: the Irish experience
Q64110375Types of Erythropoietin-Stimulating Agents and Mortality among Patients Undergoing Hemodialysis
Q61866159Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS)
Q50547672Usage of erythropoiesis-stimulating agents in cancer patients at an academic cancer center and experience with specific care management tools for anemia.
Q41229491Use of Aspirin in normalization of recombinant human erythropoietin-mediated hyper-reactivity of platelets in rats.
Q37368733Use of agents stimulating erythropoiesis in digestive diseases
Q92373776Usefulness of mid-week hemoglobin measurement for anemia management in patients undergoing hemodialysis: a retrospective cohort study
Q35851384Variant hemoglobin phenotypes may account for differential erythropoiesis-stimulating agent dosing in African-American hemodialysis patients
Q82774685Vitamin D deficiency and anemia in early chronic kidney disease
Q35782007Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forward
Q48196600What crit?
Q37778263What is causing the mortality in treating the anemia of chronic kidney disease: erythropoietin dose or hemoglobin level?
Q73819961When should we start erythropoietin therapy?
Q36666760White thrombus formation in blood tubing lines in a chronic hemodialysis unit
Q49064969Why does the treatment of anaemia not improve cardiac outcomes in CKD?
Q33882103Why is protein-energy wasting associated with mortality in chronic kidney disease?
Q82564790[Correction of anemia in renal insufficiency: what target?]
Q84569484[Hemoglobin rate and cardiovascular risk]
Q54434317[Iron deficiency, thrombocytosis and thromboembolism].
Q87061028[Patient Blood Management : three pillar strategy to improve outcome through avoidance of allogeneic blood products]
Q82520568[Renal anemia - an important secondary disease in renal insufficiency]
Q79314860[Therapy and prophylaxis of renal failure]
Q84385085[Update on the management of anemia. Nephrology World Congress 2009]

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