The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

scientific article published on 01 August 1998

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-894X(98)00366-7
P698PubMed publication ID9873516

P50authorJesper WengelQ39943435
Ravindra KumarQ59195879
P2093author name stringS K Singh
M Meldgaard
V K Rajwanshi
A A Koshkin
P2860cites workBicyclo-DNA: a Hoogsteen-selective pairing systemQ71533666
The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexesQ34645854
Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidineQ38317439
4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptaseQ38320202
Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivityQ39717918
Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?Q42554048
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognitionQ56289031
Synthesis of 2′-O,3′-C-linked bicyclic nucleosides and bicyclic oligonucleotidesQ56956405
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)2219-2222
P577publication date1998-08-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleThe first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA
P478volume8

Reverse relations

cites work (P2860)
Q42876250A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes
Q27689082A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex
Q37536687Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs
Q39256509Amido-bridged nucleic acids (AmNAs): synthesis, duplex stability, nuclease resistance, and in vitro antisense potency
Q38293518Antisense oligonucleotides, microRNAs, and antibodies.
Q34608717Antisense therapy in neurology
Q51449777Application of locked nucleic acid-based probes in fluorescence in situ hybridization.
Q37619467Application of locked nucleic acids to improve aptamer in vivo stability and targeting function
Q33770583Application of nucleic acid amplification in clinical microbiology
Q44235024Broadly targeted triplex real-time PCR detection of influenza A, B and C viruses based on the nucleoprotein gene and a novel "MegaBeacon" probe strategy
Q36918516Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.
Q38291584Cellular delivery of locked nucleic acids (LNAs).
Q38089865Characterisation of aptamers for therapeutic studies
Q39314188Chemically modified oligonucleotide-increased stability negatively correlates with its efficacy despite efficient electrotransfer.
Q89901300Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model
Q34989670Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model
Q28821789Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer
Q42970131Crystallization and X-ray diffraction analysis of an 'all-locked' nucleic acid duplex derived from a tRNA(Ser) microhelix
Q33499182Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer
Q37083226DNA mimics for the rapid identification of microorganisms by fluorescence in situ hybridization (FISH).
Q37277384Delivery of RNAi-Based Oligonucleotides by Electropermeabilization
Q33843195Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro
Q64215383Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes
Q40178131Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization.
Q42912724Development and validation of a real-time quantitative PCR assay for rapid identification of Bacillus anthracis in environmental samples
Q36462531Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration
Q39656924Dystrophin Orchestrates the Epigenetic Profile of Muscle Cells Via miRNAs
Q37655781Enhanced splice correction by 3', 5'-serinol and 2'-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells
Q46242046Entamoeba Species in South Africa: Correlations With the Host Microbiome, Parasite Burdens, and First Description of Entamoeba bangladeshi Outside of Asia
Q110527908FISHji: New ImageJ macros for the quantification of fluorescence in epifluorescence images
Q27489859Hepatitis C Virus RNA Quantitation in Venous and Capillary Small-Volume Whole-Blood Samples
Q39206108High-Throughput Genotyping with TaqMan Allelic Discrimination and Allele-Specific Genotyping Assays.
Q35053931Hybridization-based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes
Q36766899IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes
Q63761327Improved DNA Clamps by Stacking to Adjacent Nucleobases
Q24575551Improved LNA probe-based assay for the detection of African and South American yellow fever virus strains
Q59006897Improved Synthesis of 2′-Amino-LNA
Q37775492In vitro and ex vivo selection procedures for identifying potentially therapeutic DNA and RNA molecules.
Q38138569In vitro selection of BNA (LNA) aptamers
Q61640829Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche
Q34628844Internalization of Locked Nucleic Acids/DNA Hybrid Oligomers into Escherichia coli.
Q38296803LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.
Q34175818LNA: a versatile tool for therapeutics and genomics
Q59006209Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics
Q31967436Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.
Q36440340Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics.
Q47258279Long Noncoding RNA in Cancer: Wiring Signaling Circuitry
Q28076754MicroRNA-Based Therapy in Animal Models of Selected Gastrointestinal Cancers
Q37726449MicroRNA-mediated gene silencing
Q28087258MicroRNAs as potential target in human bone and soft tissue sarcoma therapeutics
Q96431878MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Q38299993Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.
Q58695794Modified RNA triplexes: Thermodynamics, structure and biological potential
Q90279052Molecular Dynamics Study of the Hybridization between RNA and Modified Oligonucleotides
Q36012531Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future
Q40969318NMR solution structure of a parallel LNA quadruplex.
Q90702126Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer
Q38871741Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes
Q90743959Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides
Q37806645Nucleic acid-based fluorescent probes and their analytical potential.
Q48288187Oligonucleotide therapies for disorders of the nervous system
Q38172172Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective
Q58183450On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide
Q38317266Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models.
Q39021941Preparation and application of triple helix forming oligonucleotides and single strand oligonucleotide donors for gene correction
Q38316276Quality control certification of RNA aptamer-based detection
Q54295403Quick regulation of mRNA functions by a few seconds of photoirradiation.
Q46432236RNA Protection is Effectively Achieved by Pullulan Film Formation.
Q56762421Real-time Fluorescent PCR Techniques to Study Microbial–Host Interactions
Q34393190Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior
Q57804904Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas
Q37336250Simultaneous detection and differentiation of human rhino- and enteroviruses in clinical specimens by real-time PCR with locked nucleic Acid probes
Q43591278Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach
Q38344609Strong positional preference in the interaction of LNA oligonucleotides with DNA polymerase and proofreading exonuclease activities: implications for genotyping assays
Q54288888Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases.
Q92228696Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy
Q64039292Targeted Oligonucleotides for Treating Neurodegenerative Tandem Repeat Diseases
Q87404754Targeted genome modification via triple helix formation
Q40622253Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices.
Q33352351Two AP2 family genes, supernumerary bract (SNB) and Osindeterminate spikelet 1 (OsIDS1), synergistically control inflorescence architecture and floral meristem establishment in rice
Q38668251microRNAs and Neurodegenerative Diseases

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