MicroRNA-mediated gene silencing

scientific article published on 27 October 2009

MicroRNA-mediated gene silencing is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S1877-1173(09)90005-9
P698PubMed publication ID20374742

P2093author name stringGabriele Fuchs
Karen A Wehner
Peter Sarnow
Cara T Pager
P2860cites workMicroRNAs: expression, avoidance and subversion by vertebrate virusesQ36567350
The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target geneQ36752403
Argonaute proteins: mediators of RNA silencingQ36845844
Potent and nontoxic antisense oligonucleotides containing locked nucleic acidsQ36985622
Getting to the root of miRNA-mediated gene silencingQ37055551
Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteinsQ37087245
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cellsQ37487108
miRNA in situ hybridization in formaldehyde and EDC-fixed tissuesQ39612232
Human let-7a miRNA blocks protein production on actively translating polyribosomesQ40204130
Temporal pattern formation by heterochronic genesQ41689518
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogasterQ41986263
P-body formation is a consequence, not the cause, of RNA-mediated gene silencingQ42738042
RNA interference in mammalian cells by chemically-modified RNA.Q44496696
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decayQ46698175
Thirty-three years later, a glimpse at the ribonuclease III active site.Q52122849
Heterochronic mutants of the nematode Caenorhabditis elegans.Q52272168
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.Q52679873
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognitionQ56289031
Recapitulation of short RNA-directed translational gene silencing in vitroQ56899069
MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4FQ58880697
The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNAQ59008168
Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon responseQ64376895
Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2'-Amino- and 2'-Thio-LNA Monomeric NucleosidesQ74838441
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54Q21146051
The nuclear RNase III Drosha initiates microRNA processingQ24295234
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsQ24302072
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNAQ24308839
The Microprocessor complex mediates the genesis of microRNAsQ24312976
Cellular cofactors affecting hepatitis C virus infection and replicationQ24317564
The Drosha-DGCR8 complex in primary microRNA processingQ24318603
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemQ24328771
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic specklesQ24515264
A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodiesQ24537397
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencingQ24537549
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail functionQ24538996
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodiesQ24540223
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAsQ24540256
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesQ24554481
Identification of mammalian microRNA host genes and transcription unitsQ24562298
The microRNA RegistryQ24600787
Human let-7 stem-loop precursors harbor features of RNase III cleavage productsQ24641956
Argonaute HITS-CLIP decodes microRNA-mRNA interaction mapsQ24645826
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liverQ24649633
microRNA-122 stimulates translation of hepatitis C virus RNAQ24654912
Deadenylation is a widespread effect of miRNA regulationQ24655139
Integration of microRNA miR-122 in hepatic circadian gene expressionQ24657953
A role for the P-body component GW182 in microRNA functionQ24669847
Stress granules and processing bodies are dynamically linked sites of mRNP remodelingQ24678779
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodiesQ24681266
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionalityQ24794430
Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.Q27469999
Interferon modulation of cellular microRNAs as an antiviral mechanismQ27489711
Argonaute2 is the catalytic engine of mammalian RNAiQ27860545
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansQ27860584
An extensive class of small RNAs in Caenorhabditis elegansQ27860626
Nuclear export of microRNA precursorsQ27860686
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAQ27860813
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Q27860849
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Q27860893
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegansQ27860895
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timingQ27860903
Identification of novel genes coding for small expressed RNAsQ27860917
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAQ27861092
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansQ27861103
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNAQ27861124
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing BodiesQ27931286
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
Involvement of microRNA in AU-rich element-mediated mRNA instabilityQ28118466
Switching from repression to activation: microRNAs can up-regulate translationQ28131790
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factorQ28140045
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translationQ28143010
Identification of eight members of the Argonaute family in the human genomeQ28156128
Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal regionQ28198282
Internal ribosome entry sites in eukaryotic mRNA moleculesQ28205551
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsQ28215061
Purified Argonaute2 and an siRNA form recombinant human RISCQ28242666
Identification of virus-encoded microRNAsQ28259309
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradationQ28268899
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegansQ28274449
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translationQ28281118
Disruption of GW bodies impairs mammalian RNA interferenceQ28281500
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesisQ28297566
Phylogenetic shadowing and computational identification of human microRNA genesQ28302536
The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental eventsQ28302778
Specificity of microRNA target selection in translational repressionQ28776123
miR-122 regulation of lipid metabolism revealed by in vivo antisense targetingQ29547487
MicroRNA biogenesis: coordinated cropping and dicingQ29547496
MicroRNAs direct rapid deadenylation of mRNAQ29614566
siRNAs can function as miRNAsQ29615070
Processing bodies require RNA for assembly and contain nontranslating mRNAsQ29615264
LNA-mediated microRNA silencing in non-human primatesQ29615962
Identification of microRNAs of the herpesvirus familyQ29618671
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTRQ29619777
Mechanism of action of interferon and ribavirin in treatment of hepatitis CQ29619805
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotideQ30048476
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cellsQ30476196
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencingQ33300646
Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirusQ33883910
Identification and characterization of human cytomegalovirus-encoded microRNAsQ33987509
Mutations that lead to reiterations in the cell lineages of C. elegansQ34282331
Gene silencing using micro-RNA designed hairpinsQ34364532
Short RNAs repress translation after initiation in mammalian cells.Q34495292
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathwaysQ34530552
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cellsQ34558129
Antisense properties of duplex- and triplex-forming PNAsQ34588984
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.Q34592976
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAsQ34593731
The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.Q34626453
Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.Q34658219
Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genomeQ34795106
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapyQ34915120
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.Q34927797
Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2.Q34951363
Cell-cell contact globally activates microRNA biogenesis.Q34975000
MicroRNA functions in animal development and human diseaseQ36285673
P921main subjectmicroRNAQ310899
gene silencingQ1431332
P304page(s)187-210
P577publication date2009-10-27
P1433published inProgress in Molecular Biology and Translational ScienceQ15753415
P1476titleMicroRNA-mediated gene silencing
P478volume90

Reverse relations

cites work (P2860)
Q90171087AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo
Q39146357Bortezomib induces apoptosis of endometrial cancer cells through microRNA-17-5p by targeting p21.
Q34312220Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration
Q39585468Down-regulation of miR-23b may contribute to activation of the TGF-β1/Smad3 signalling pathway during the termination stage of liver regeneration
Q34229869Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration
Q34514751Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells
Q37022882Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency
Q36068338Simultaneous Determination of Multiple microRNA Levels Utilizing Biotinylated Dideoxynucleotides and Mass Spectrometry
Q38989748miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells
Q38799066miR-26a regulates mouse hepatocyte proliferation via directly targeting the 3' untranslated region of CCND2 and CCNE2.

Search more.