Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

scientific article published on May 2000

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2000PNAS...97.5633W
P356DOI10.1073/PNAS.97.10.5633
P932PMC publication ID25880
P698PubMed publication ID10805816
P5875ResearchGate publication ID235610809

P50authorTomas HökfeltQ2440397
Jesper WengelQ39943435
P2093author name stringC Wahlestedt
M Ossipov
J Lai
K Ren
L Good
F Porreca
T Johnsson
J Skouv
C Broberger
P Salmi
A Koshkin
J Kela
H Oerum
M H Jacobsen
N Jakobsen
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Modification of phosphorothioate oligonucleotides yields potent analogs with minimal toxicity for antisense experiments in the CNS.Q38331826
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Antisense oligonucleotide strategies in neuropharmacologyQ40744215
A good antisense molecule is hard to findQ41736928
Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?Q42554048
Antisense oligodeoxynucleotide to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu- or kappa-opioid receptor agonists in the mouseQ44336744
Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat.Q44341836
An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in miceQ44343549
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Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat.Q48173267
Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctionsQ48283998
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Keeping the biotechnology of antisense in context.Q54157081
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognitionQ56289031
A Novel Class of Oligonucleotide Analogues Containing 2‘-O,3‘-C-Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular ModelingQ56956351
Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)Q59007889
LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA DuplexesQ59007996
Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell lineQ72425831
Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brainQ73387828
Antisense therapeuticsQ77297328
Vitravene--another piece in the mosaicQ77319598
Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effectsQ77749810
Antisense oligonucleotides - the way forwardQ84337936
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)5633-5638
P577publication date2000-05-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePotent and nontoxic antisense oligonucleotides containing locked nucleic acids
P478volume97

Reverse relations

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