Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

scientific article published in Nature

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1032098121
P356DOI10.1038/292060A0
P698PubMed publication ID6974307

P2093author name stringA Ben-Nun
H Wekerle
I R Cohen
P2860cites workSpecific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptorsQ36360063
Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibodyQ39372021
The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitisQ53438445
Spontaneous remission of autoimmune encephalomyelitis is inhibited by splenectomy, thymectomy or ageingQ59080099
Basic encephalitogenic protein: A simplified purification on sulphoethyl-sephadexQ77923113
P433issue5818
P407language of work or nameEnglishQ1860
P304page(s)60-61
P577publication date1981-07-01
P1433published inNatureQ180445
P1476titleVaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
P478volume292

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cites work (P2860)
Q371462762015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis
Q37217037A Journey in Science: The Privilege of Exploring the Brain and the Immune System
Q37689107A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry
Q35868821A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE.
Q37611832A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis
Q47300929ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation
Q42449804Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase
Q41440977Adoptive transfer of experimental allergic encephalomyelitis: Recipient response to myelin basic protein-reactive lymphocytes
Q26776191Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology
Q35769472An integrated model of immunoregulation mediated by regulatory T cell subsets
Q40660123Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells
Q36570660Anti-ergotypic immunoregulation
Q36635307Antigen Recognition and Peptide-Mediated Immunotherapy in Autoimmune Disease
Q44732388Antigen-Specific Tolerance Induced by Autoimmunization with Photoinactivated Syngeneic Effector Cells
Q35173096Antigen-Specific Tolerance as a Therapy for Experimental Autoimmune Encephalomyelitis
Q36327373Antigen-specific therapies in multiple sclerosis.
Q24791647Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis
Q35129731Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins
Q37525926Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans
Q34600354Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II
Q35861182Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
Q38593255Autoimmune disease and vaccination: impact on infectious disease prevention and a look at future applications
Q33850715Autoimmune maintenance and neuroprotection of the central nervous system
Q35315562Autoimmune thyroiditis and targeted anti-T cell immunotherapy in man.
Q37210493Autologous T-cell vaccination for multiple sclerosis: a perspective on progress
Q37667281Autophagy and Autophagy-Related Proteins in CNS Autoimmunity.
Q35173092Autoreactive T Cells in Multiple Sclerosis
Q46181359Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis
Q36148448Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab
Q41340339Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice
Q80455478CD28:B7 interaction is necessary for the protective effect of T cell vaccination in EAE
Q34596822CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis
Q35940569CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice
Q35546583CDR1 T-cell receptor beta-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions.
Q41625265Cell biology of autoimmune diseases
Q36752532Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat.
Q39678803Cell-mediated autoimmunity in type I diabetes
Q40897925Characterization and role in experimental systemic lupus erythematosus of T-cell lines specific to peptides based on complementarity-determining region-1 and complementarity-determining region-3 of a pathogenic anti-DNA monoclonal antibody
Q34056715Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines
Q41466292Characterization of brain-isolated rat encephalitogenic T cell lines
Q34251404Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen
Q37385073Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.
Q64996165Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.
Q39029104Cytokine networks in neuroinflammation
Q35674246Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
Q68810884Delayed type hypersensitivity (DTH) to type II collagen (CII) in DBA-1 mice
Q71710403Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis
Q38207555Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal
Q33780614Distinct levels of regulation in organ-specific autoimmune diseases
Q41577465Diverse T cell receptor beta chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein.
Q35173105EAE: a model for immune intervention with synthetic peptides
Q40905084Early rheumatoid arthritis. Future treatment
Q59065422Effector T lymphocyte line cells migrate to the thymus and persist there
Q72087428Effects of staphylococcal enterotoxin B on T cell receptor Vβ utilization and clinical manifestations of experimental allergic encephalomyelitis
Q35581158Emerging disease modifying therapies for multiple sclerosis
Q37559970Emerging immunopharmacological targets in multiple sclerosis
Q36868435Emerging therapies for MS.
Q67900407Evidence of Limited Variability of Antigen Receptors on Intrathyroidal T Cells in Autoimmune Thyroid Disease
Q41293419Experimental immunotherapies for multiple sclerosis.
Q44140287Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy. Initial observations
Q40435658Extracorporeal Photopheresis — A New Approach for the Treatment of Cutaneous T Cell Lymphomas
Q73086625Extracorporeal photochemotherapy: a historical perspective
Q70817704Extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma--the Düsseldorf and Munich experience
Q36203561Feedback regulation of autoimmunity via TCR-centered regulation
Q47817669Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination
Q48170011Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
Q34700416Generalization of single immunological experiences by idiotypically mediated clonal connections
Q46381533Genetic control of experimental autoimmune encephalomyelitis at the level of cytotoxic lymphocytes in guinea pigs
Q35936495Homeostatic control of immunity by TCR peptide-specific Tregs
Q34200068Identification of cellular infiltrates during early stages of brain inflammation with magnetic resonance microscopy
Q39592364Idiotypes and autoimmunity
Q40115308Idiotypes and autoimmunity
Q46301718Immunity and the nervous system: Basic tenets
Q41561705Immunobiology and immunotherapeutic implications of syngeneic/autologous graft-versus-host disease.
Q40437100Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Q38677378Immunological phenomena observed in the testis and their possible role in infertility
Q41722148Immunological treatment of autoimmune diseases.
Q41684443Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen–Ia complex
Q37785554Immunomodulatory drug treatment in multiple sclerosis
Q77922185Immunoregulation of experimental autoimmune encephalomyelitis: editorial overview
Q35646266Immunoregulation: studies of physiological and therapeutic autoreactivity by T cell vaccination
Q72695857Immunospecific inhibition of nerve conduction by T lymphocytes reactive to basic protein of myelin
Q40392025Immunotherapeutic Strategies Directed at the Trimolecular Complex
Q59047650Immunotherapy by peptides?
Q71607031Immunotherapy for multiple sclerosis: from theory to practice
Q38083041Immunotherapy of multiple sclerosis: the state of the art.
Q72819788In vitro and in vivo actions of acetylcholine receptor educated suppressor T cell lines in murine experimental autoimmune myasthenia gravis
Q68309825In vivo evidence for CD4+ and CD8+ suppressor T cells in vaccination-induced suppression of murine experimental autoimmune thyroiditis
Q36367554Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE).
Q67862542Inhibition of Antiskin Allograft Immunity Induced by Infusions with Photoinactivated Effector T Lymphocytes (PET Cells). Is In Vivo Cell Transferrable?
Q68434385Inhibition of the mixed lymphocyte reaction by T cell vaccination
Q34546121Insights into the immunopathogenesis of multiple sclerosis
Q41138242Involvement of CD80 in the generation of CD4+ cytotoxic T cells.
Q70118422Is there restricted T cell receptor usage in autoimmune disease?
Q43407524Isolation and characterisation of human T-cell lines from a patient with Chagas' disease
Q46538947Isolation of myelin basic protein-reactive T-cell lines from normal human blood
Q33630513Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures
Q46081307Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients
Q54503292Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis
Q70053363Long-term depletion of CD8+ T cells in vivo in the rat: no observed role for CD8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis
Q34224070Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.
Q41528229MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination
Q35838783Management of early inflammatory arthritis. Intervention with immunomodulatory agents: T cell vaccination
Q35183850Mechanisms of action of extracorporeal photochemotherapy
Q40650026Mechanisms of autoimmunity and AIDS: prospects for therapeutic intervention
Q37424674Mechanisms of resistance to autoimmune disease induced by T-cell vaccination
Q68968824Modulation of experimental allergic encephalomyelitis (EAE): suppression of active reinduction of EAE in rats recovered from passively transferred disease
Q37582663Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis?
Q36703890Mycosis fungoides--a review of the management of 28 patients and of the recent literature
Q40399925Myelin basic protein-reactive T cells in multiple sclerosis: pathologic relevance and therapeutic targeting
Q73336431Myelin reactive T cells after T cell vaccination in multiple sclerosis: cytokine profile and depletion by additional immunizations
Q42122517Network regulation of autoimmunity: an automation model
Q38164272New therapeutic approaches to autoimmune disease
Q40486693On the Regulation of EAE
Q36370956Optic Neuritis, A New Variant of Experimental Encephalomyelitis, A Durable Model for All Seasons, Now In Its Seventieth Year
Q37526320Parasitic infection and autoimmunity
Q41540057Pathogenic and non-pathogenic T lymphocytes specific for the encephalitogenic epitope of myelin basic protein: Functional characteristics and vaccination properties
Q38031780Photopheresis (extracorporeal photochemotherapy).
Q36968740Photopheresis: a Clinically Relevant Immunobiologic Response Modifier
Q36987846Photopheresis: a new therapeutic concept
Q33955168Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses
Q46730648Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat-shock protein
Q54524412Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide.
Q40303030Prolongation of survival of rat cardiac allografts by T cell vaccination
Q36715655Prospects for Immunotherapy Directed to the T Cell Receptor in Human Autoimmune Disease
Q35936489Qa-1 restriction of CD8+ suppressor T cells
Q74233043Rational approaches to immune regulation
Q63433111Recent advances in the development of vaccines for chronic inflammatory autoimmune diseases
Q39480719Regulation of autoimmune disease physiological and therapeutic
Q41447168Regulation of experimental autoimmune encephalomyelitis: Inhibition of adoptive experimental autoimmune encephalomyelitis by ‘recovery-associated suppressor cells’
Q37449469Regulation of mycobacterial heat-shock protein-reactive T cells by HLA class II molecules: lessons from leprosy
Q45149123Regulation of retinal autoimmunity via the idiotypic network
Q36203550Regulatory T cells in autoimmune diseases: anti-ergotypic T cells
Q72751257Relevance of experimental allergic encephalomyelitis to multiple sclerosis
Q54361544Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes.
Q52895006Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations.
Q52895013Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRV beta 6 CDR2 peptide.
Q67655164Reversal of autoimmune encephalomyelitis by membranes presenting myelin basic protein-associated class II MHC molecule as an approach to immunotherapy of organ-specific autoimmune diseases
Q52374508Reverse engineering: a model for T-cell vaccination.
Q79841487Reviving suppression?
Q35981635Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis
Q35721897Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.
Q34530472Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats
Q34307160Selective immunointervention in autoimmune diseases: lessons from multiple sclerosis
Q46201877Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
Q70128226Staphylococcal enterotoxin B as a potent suppressant of T cell proliferative responses in rats
Q67537113Staphylococcal enterotoxin B as a potent suppressant of T lymphocytes: trace levels suppress T lymphocyte proliferative responses
Q68937793Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes
Q39302720Strategies for the treatment of myasthenia gravis
Q40838126Strategies for treatment of myasthenia gravis
Q37370531Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes
Q54385154Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions.
Q71253878Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
Q90341485Systematic Understanding of Bioactive Lipids in Neuro-Immune Interactions: Lessons from an Animal Model of Multiple Sclerosis
Q40486720T Cell Regulatory Circuitry: Antigen-Specific and TCR-Idiopeptide-Specific T Cell Interactions in EAE
Q54282778T Cell Vaccination in Autoimmune Diseases
Q48268219T Cell-Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity
Q39821470T cell approach to demyelinating diseases
Q36375972T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance. The response in the "tolerant" mouse within the residual repertoire is quantitatively simila
Q67294480T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): oligoclonality of PBC-derived T cell clones
Q36731895T cell receptors, immunoregulation, and autoimmunity
Q70567369T cell regulation of collagen-induced arthritis in mice. II. Immunomodulation of arthritis by cytotoxic T cell hybridomas specific for type II collagen
Q71655892T cell regulation of collagen-induced arthritis in mice. III. Is T cell vaccination a valuable therapy?
Q78074655T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis
Q36359571T cell targeted immunotherapy for autoimmune disease
Q34524948T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial
Q54284373T cell vaccination does not induce resistance to experimental autoimmune neuritis
Q36887916T cell vaccination in multiple sclerosis
Q42692324T cell vaccination in multiple sclerosis patients with autologous CSF-derived activated T cells: results from a pilot study
Q40873787T cell vaccination in secondary progressive multiple sclerosis
Q36475992T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells
Q37398254T cell vaccination inhibits Th1/Th17/Tfh frequencies and production of autoantibodies in collagen-induced arthritis
Q40841596T cell vaccines for autoimmune diseases
Q40392456T cells as antigen-presenting cells
Q48641261T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis
Q72698011T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells
Q37613627T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis
Q53897545T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.
Q37580195T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis
Q77118268T-cell receptor peptide vaccination in the treatment of rheumatoid arthritis
Q39811197T-cell seeding: neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of experimental autoimmune encephalitis
Q28209871T-cell vaccination for autoimmune disease: a panorama
Q28155795T-cell vaccination for autoimmune diseases: immunologic lessons and clinical experience in multiple sclerosis
Q77152260T-cell vaccination: from basics to the clinic
Q37755259T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination
Q35050030T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to alpha-galactosylceramide are impaired
Q41547123T-helper epitopes on human nicotinic acetylcholine receptor in myasthenia gravis.
Q77922223TCR peptide-reactive T cells and peripheral tolerance to myelin basic protein
Q78008041Testicular-associated immune deviation: flushing of the testicular lymph sinusoids induces immunosuppression and inhibits formation of EAE in SJL mice
Q36924516The 65-kDa heat-shock protein in the pathogenesis, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice
Q36665881The Development of Rational Strategies for Selective Immunotherapy against Autoimmune Demyelinating Disease
Q37511805The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation
Q67710575The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis
Q40465752The T-cell receptor in multiple sclerosis.
Q40486710The Ups and Downs of EAE
Q40490257The V-region disease hypothesis: new evidence suggests it is probably wrong
Q36560083The autoimmune T cell receptor: Epitopes, idiotopes, and malatopes
Q53989102The clonal composition of myelin basic protein-reactive encephalitogenic T cell populations is influenced both by the structure of relevant antigens and the nature of antigen-presenting cells.
Q37208525The gray aspects of white matter disease in multiple sclerosis
Q34582895The immunological basis for treatment of multiple sclerosis
Q38237315The mechanisms and applications of T cell vaccination for autoimmune diseases: a comprehensive review
Q40403377The relationship between human multiple sclerosis and rodent experimental allergic encephalomyelitis
Q40774156The role of thymic epithelium in the establishment of transplantation tolerance
Q36027486The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.
Q40433245Therapeutic Regulation of T Cells in Rheumatoid Arthritis
Q34635952Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure
Q40518542Therapy for multiple sclerosis.
Q33713319Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein.
Q44053840Tolerance to experimental contact sensitivity induced by T cell vaccination
Q37874615Tovaxin for multiple sclerosis
Q41200073Treatment of Adult T Cell Leukaemia by Extracorporeal Photochemotherapy
Q35936500Tregs in T cell vaccination: exploring the regulation of regulation
Q44744832Trials of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide
Q38212474Updating ECP action mechanisms
Q73794968Use of an alloreactive lymphocyte vaccine to prolong rat cardiac allograft survival
Q71064647Vaccination against autoimmune encephalomyelitis (EAE): Attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line
Q37476298Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.
Q71623298Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL
Q37085898Vaccines for multiple sclerosis: progress to date