Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

scientific article published in Nature

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1002229247
P356DOI10.1038/301621A0
P698PubMed publication ID6828143

P2093author name stringA S Kraft
W B Anderson
P2860cites workEvidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinaseQ33986868
Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosineQ34251462
Phorbol ester induction of leukemic cell differentiation is a membrane-mediated processQ36293879
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazineQ36417838
Cellular location of viral transforming proteinsQ40122488
Protein kinase activity associated with polyoma virus middle T antigen in vitroQ40279907
Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cellsQ42829613
Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicityQ45077792
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virusQ45105517
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factorQ59074365
On the biochemical mechanism of tumorigenesis in mouse skin. VI. Early effects of growth-stimulating phorbol esters on phosphate transport and phospholipid synthesis in mouse epidermisQ68793877
Generation of 1,2-diacylglycerol in plasma membranes of phorbol ester-treated myoblastsQ70996389
Intracellular calcium and skin tumor promotion: calcium regulation of the induction of epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetateQ71576997
Phospholipid-sensitive calcium-dependent protein kinase: Inhibition by antipsychotic drugsQ72466494
P433issue5901
P407language of work or nameEnglishQ1860
P304page(s)621-623
P577publication date1983-02-01
P1433published inNatureQ180445
P1476titlePhorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane
P478volume301

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cites work (P2860)
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Q37351753Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis
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Q35047618Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies
Q41375043Expression of potassium channels in epithelial cells depends on calcium-activated cell-cell contacts
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Q42844974Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin
Q41092486FKBP-12 is not an inhibitor of protein kinase C.
Q105009561Frondosins, five new sesquiterpene hydroquinone derivatives with novel skeletons from the sponge Dysidea frondosa: Inhibitors of interleukin-8 receptors
Q40620450Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-κB and tumor necrosis factor α in LLC-PK1 cells
Q40427114Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis
Q34707946Further characterization of tumor-promoter-mediated activation of protein kinase C
Q42033238Ganglioside GQ1b-induced terminal differentiation in cultured mouse keratinocytes. Phosphoinositide turnover forms the onset signal
Q35608974Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells. Role of protein kinase C.
Q47981758Growth and metabolism of fetal and maternal muscles of adolescent sheep on adequate or high feed intake: possible role of protein kinase C-alpha in fetal muscle growth
Q28364243HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction
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Q40064034Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C
Q34386778Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure
Q48636735Histamine-stimulated cyclic AMP formation in the chick pineal gland: role of protein kinase C.
Q41471721Historical review of research on protein kinase C in learning and memory
Q37556680Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells
Q36807673Hypothalamic protein kinase C regulates glucose production
Q48500270Hypothermia attenuates the activation of protein kinase C in focal ischemic rat brain: dual autoradiographic study of [3H]phorbol 12,13-dibutyrate and iodo[14C]antipyrine
Q48627481Hypothermia prevents the ischemia-induced translocation and inhibition of protein kinase C in the rat striatum.
Q48549898Hypoxic ventilatory roll-off is associated with decreases in protein kinase C activation within the nucleus tractus solitarius of the rat.
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Q42543239Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
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Q40613339Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells
Q47890485Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns
Q41560914Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association
Q42828372Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes
Q36832773Immunological evidence for two physiological forms of protein kinase C.
Q69489557Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes
Q42872502Immunomodulatory Effects of Dietary Exposure to Selected Polycyclic Aromatic Hydrocarbons in the Bluegill (Lepomis macrochirus)
Q34934364Immunosuppression in Hamsters with Progressive Visceral Leishmaniasis Is Associated with an Impairment of Protein Kinase C Activity in Their Lymphocytes That Can Be Partially Reversed by Okadaic Acid or Anti-Transforming Growth Factor β Antibody
Q67927643Impaired translocation of protein kinase C activity in human non-insulin-dependent diabetes mellitus
Q73083082Implication of protein kinase C in mechanisms of potassium-induced long-term potentiation in rat hippocampal slices
Q46827561Improvement in cardiac function of diabetic rats by bosentan is not associated with changes in the activation of PKC isoforms
Q34604328In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia
Q42829929Inactive membrane protein kinase Cs: a possible target for receptor signalling
Q55487351Increased diacylglycerol levels inhibit [20-3H]phorbol 12,13-dibutyrate binding and the glucocorticoid-mediated increase in glycerol phosphate phosphate dehydrogenase levels in C6 rat glioma cells.
Q41627661Induction of differentiation and c‐jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases
Q42806094Inhibition of 80 kDa protein phosphorylation by short-wavelength UV light in NIH 3T3 cells
Q42817632Inhibition of cell communication between Balb/c 3t3 cells by tumor promoters and protection by cAMP
Q37539915Inhibition of gonadotropin-induced granulosa cell differentiation by activation of protein kinase C.
Q44618104Inhibition of phorbol ester-induced neutrophil chemiluminescence by FeLV.
Q33716135Inhibition of protein kinase C--do we, can we, and should we?
Q41996779Inhibitory action of polyamines on protein kinase C association to membranes
Q33645805Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC-α translocation
Q69814184Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I).poly(C) in human amnion cells (UAC)
Q40094697Inositol trisphosphate and diacylglycerol as second messengers
Q41535057Insulin receptor substrate 1 is a substrate of the Pim protein kinases.
Q44222327Interaction of palmitoylcarnitine with protein kinase C in neuroblastoma NB-2a cells
Q59095897Interleukin-2 stimulates association of protein kinase C with plasma membrane
Q69297042Internalization of interleukin 1 (IL 1) correlates with IL 1-induced IL 2 receptor expression and IL 2 secretion of EL4 thymoma cells
Q48164797Intracellular analysis of potentiation of CA1 hippocampal synaptic transmission by phorbol ester application
Q45971419Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme
Q42444350Intracellular signaling pathways involved in mediating the effects of lead on the transcription factor Sp1.
Q40081072Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
Q48933581Investigations of the role of protein kinase C in the acute sedative effects of ethanol
Q68257173Involvement of a calcium-phospholipid-dependent protein kinase in the maturation of Xenopus laevis oocytes
Q35644623Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Q57200964Involvement of the CD4 molecule in a post-activation event on T cell proliferation
Q40608286Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells
Q40139606Is the Maturation Arrest in Myeloid Leukemia Reversible?
Q36220125Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton
Q34597455Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family
Q48091871Kindled amygdaloid seizures in rats cause immediate and transient increase in protein kinase C activity followed by transient suppression of the activity
Q44397569Lectin-induced enhancement of voltage-dependent calcium flux and calcium channel antagonist binding
Q77350054Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle
Q69239080Lithium inhibition of protein kinase C activation-induced serotonin release
Q93048590Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication
Q48324355Measurement of hippocampal levels of cellular second messengers following in situ freezing
Q70200428Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands
Q36485580Mechanisms of lead neurotoxicity
Q37600870Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation
Q72784962Microsomal Ca2+- and phospholipid-dependent protein kinase. Identification and in vitro binding studies
Q42481609Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C
Q36236661Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes
Q68805956Models and mechanisms for signal transduction in B cells
Q35585769Modulation by 1,25-dihydroxycholecalciferol of the acute change in cytosolic free calcium induced by thyrotropin-releasing hormone in GH4C1 pituitary cells
Q39760102Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells
Q42811855Modulation of cytosolic protein kinase C activity by ferricyanide: priming event seems transmembrane redox signalling. A study on transformed C3H/10T1/2 cells in culture
Q34562651Modulation of human platelet protein kinase C by endotoxic lipid A.
Q48686369Modulation of protein kinase C translocation by excitatory and inhibitory amino acids in primary cultures of neurons
Q36578210Molecular Events Mediating T Cell Activation
Q48233414Muscarinic receptor- and phorbol ester-stimulated phosphorylation of protein kinase C substrates in adult and neonatal cortical slices
Q41081702Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon
Q50764390Novel determinant of PKC-epsilon anchoring at cardiac Z-lines.
Q28579107Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats
Q28382878Osmotic and phorbol ester-induced activation of Na+/H+ exchange: possible role of protein phosphorylation in lymphocyte volume regulation
Q42827007PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.
Q24672899PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system
Q64080450PKC and PKN in heart disease
Q39409529PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation
Q35106609PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
Q45293383PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy
Q40308243Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1.
Q44025401Palmitoylcarnitine modulates interaction protein kinase C delta-GAP-43.
Q43192342Parallel modulation of receptor for activated C kinase 1 and protein kinase C-alpha and beta isoforms in brains of morphine-treated rats
Q36071589Pharmacology of second messengers: a critical appraisal
Q67989338Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret
Q67988300Phorbol 12-myristate 13-acetate inhibition of leukotriene D4-induced signal transduction was rapidly reversed by staurosporine
Q48705837Phorbol Ester Receptors: Autoradiographic Identification in the Developing Rat
Q67895440Phorbol Ester and Phospholipase C-Mediated Differentiated Thyroid Function In Vitro: The Effects of Protein Kinase C Inhibition and Downregulation
Q45120362Phorbol diesters increase the phosphorylation of the leukocyte common antigen CD45 in human T cells
Q44276594Phorbol ester and 1,2-diolein are not fully equivalent activators of protein kinase C in respect to phosphorylation of membrane proteins in vitro
Q70319504Phorbol ester causes short term and transient accumulation of pteridines in T cells and in cell lines
Q37551029Phorbol ester induces a differential effect on the effector function of human allospecific cytotoxic T lymphocyte and natural killer clones
Q72733016Phorbol ester induces intracellular translocation of phospholipid/Ca2+-dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini
Q48105095Phorbol ester inhibition of current responses and simultaneous protein phosphorylation in Xenopus oocyte injected with brain mRNA.
Q41821068Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b.
Q42519395Phorbol ester prevents the thyroid-stimulating-hormone-induced but not the forskolin-induced decrease of cAMP-dependent protein kinase activity in thyroid cell cultures
Q44069854Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis
Q46114447Phorbol ester synergizes with Ca2+ ionophore in activation of protein kinase C (PKC)alpha and PKC beta isoenzymes in human T cells and in induction of related cellular functions
Q70304847Phorbol ester-induced alteration of protein kinase C catalytic properties occurs at the membrane level and is not reproduced by physiological stimuli
Q40697301Phorbol ester-mediated neurotensin secretion is dependent on the PKC-alpha and -delta isoforms
Q37685971Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors
Q67922002Phorbol esters inhibit inositol phosphate and diacylglycerol formation in proliferating HL60 cells. Relationship to differentiation
Q68899968Phorbol esters, but not epidermal growth factor or insulin, rapidly decrease soluble protein kinase C activity in rat hepatocytes
Q37509292Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells
Q67881686Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protien kinase C activation in conditions inducing differentiation in HL-60 cells
Q36233782Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells
Q73717790Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils
Q43507802Phospholipase A2-mediated release of arachidonic acid in stimulated guinea pig alveolar macrophages: interaction with lipid mediators and cyclic AMP.
Q39485569Phosphoprotein B-50: localization and function
Q34588340Phosphorylation by protein kinase C of a 20-kDa cytoskeletal polypeptide enhances its susceptibility to digestion by calpain
Q72827885Phosphorylation of high-mobility-group proteins by the calcium-phospholipid-dependent protein kinase and the cyclic AMP-dependent protein kinase
Q72400797Plasma membrane isolated from astrocytes in primary cultures. Its acceptor oxidoreductase properties
Q72809615Platelet Ca2+-activated, phospholipid-dependent protein kinase: Evidence for proteolytic activation of the enzyme in cells treated with phospholipase C
Q69204425Possible involvement of microfilaments in protein kinase C translocation
Q34603022Possible mechanism of phorbol diester-induced maturation of human promyelocytic leukemia cells
Q30470263Possible role of atypical protein kinase C activated by arachidonic acid in Ca2+ sensitization of rabbit smooth muscle
Q42369526Postsynaptic nicotinic receptor desensitized by non-contractile Ca2+ mobilization via protein kinase-C activation at the mouse neuromuscular junction
Q38672447Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance
Q69995453Proliferating and quiescent cells exhibit different subcellular distribution of protein kinase C activity
Q60370484Proliferative responses induced by the activation of protein kinase C during the development of human T lymphocytes
Q72020399Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes
Q42799424Properties of protein kinase C associated with nuclear membranes
Q36748065Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease
Q47131231Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders
Q36744811Protein Kinase Cα (PKCα) Is Resistant to Long Term Desensitization/Down-regulation by Prolonged Diacylglycerol Stimulation
Q33678033Protein Kinases as Drug Development Targets for Heart Disease Therapy
Q67465770Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation
Q51702941Protein kinase C activation does not stimulate lung liquid clearance in anesthetized sheep.
Q70147868Protein kinase C activators modulate differentiated thyroid function in vitro
Q53518922Protein kinase C activities are increased in rat thyroid epithelial cells expressing v-ras genes.
Q41521135Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta
Q41954616Protein kinase C and an endogenous substrate associated with adenohypophyseal secretory granules
Q48726149Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters
Q45953150Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.
Q45937676Protein kinase C delta mediates cerebral reperfusion injury in vivo.
Q24563407Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function
Q38292517Protein kinase C epsilon subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes
Q48679598Protein kinase C from bat brain: the enzyme from a hibernating mammal
Q42525814Protein kinase C from small intestine epithelial cells
Q41687586Protein kinase C in IL-2 signal transduction
Q69995456Protein kinase C in cytosol and cell membranes of concanavalin A-stimulated rat thymocytes
Q48766965Protein kinase C in focal ischemic rat brain: dual autoradiographic analysis of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu).
Q44095870Protein kinase C in larval brain of wild-type and dunce memory-mutant Drosophila
Q48092988Protein kinase C in primary astrocyte cultures: cytoplasmic localization and translocation by a phorbol ester
Q48228785Protein kinase C in rat brain is altered by developmental lead exposure
Q34573082Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose
Q41856516Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists
Q42516859Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture
Q41553970Protein kinase C isoenzymes in human neuroblasts. Involvement of PKC epsilon in cell differentiation.
Q38150427Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development
Q41650563Protein kinase C isoforms in human glioblastoma cells
Q52250580Protein kinase C mediates neural induction in Xenopus laevis
Q38325710Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context
Q48019473Protein kinase C modulation of ventilatory response to hypoxia in nucleus tractus solitarii of conscious rats
Q50789802Protein kinase C mutants in the auto-inhibitory region exhibit two distinct properties.
Q59070337Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
Q68822707Protein kinase C-activating phorbol esters augment expression of T cell receptor genes
Q46419582Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules
Q39836682Protein kinase C: properties and possible role in cellular division and differentiation
Q40727272Protein kinase Cɛ inhibition restores megakaryocytic differentiation of hematopoietic progenitors from primary myelofibrosis patients
Q34979083Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium
Q42511573Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway
Q35871475Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle
Q30449976Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells
Q37511358Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.
Q54442655Rapid down-regulation of protein kinase C and membrane association in phorbol ester-treated leukemia cells.
Q68406543Rapid down-regulation of protein kinase C in (Chediak-Higashi syndrome) beige mouse by phorbol ester
Q44917688Rapid effects of phorbol esters on isolated rat adipocytes. Relationship to the action of protein kinase C.
Q45033918Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs
Q36615709Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes
Q37271445Rationally designed peptide regulators of protein kinase C.
Q41471736Receptor-mediated activation of protein kinase C in hippocampal long-term potentiation: facts, problems and implications
Q39389831Redistribution of protein kinase C isoforms in association with vascular hypertrophy of rat aorta
Q39174495Redox regulation of the actin cytoskeleton and its role in the vascular system
Q41126733Regulation of interleukin-2 responses by phosphatidic acid
Q44237495Regulation of membrane-bound PKC in adult cardiac ventricular myocytes.
Q74219904Regulation of protein kinase C in the muscular layer of human placental stem villi vessels
Q59385086Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy
Q35031770Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
Q24299373Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
Q44762859Role of PKCalpha and PKCiota in phenylephrine-induced contraction of rat corpora cavernosa.
Q34560196Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids
Q42208994Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids.
Q70102378Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes
Q38183790Role of phosphoinositides in the regulation of liver function
Q41380394Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes
Q74567690Role of protein kinase C alpha in endothelin-1 stimulation of cytosolic phospholipase A2 and arachidonic acid release in cultured cat iris sphincter smooth muscle cells
Q35220755Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion.
Q28575003Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2
Q44620928Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin
Q40155730Roles of human peripheral blood leukocyte protein kinase C and G proteins in inflammatory mediator release by isogenic Escherichia coli strains
Q42868249Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate
Q40491299Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway
Q37715946Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons
Q26827704Sensory TRP channel interactions with endogenous lipids and their biological outcomes
Q44866629Short-term treatment with cell wall degrading enzymes increases the activity of the inositol phospholipid kinases and the vanadate-sensitive ATPase of carrot cells
Q33898630Signal transduction in esophageal and LES circular muscle contraction
Q40154363Signal transduction in human platelets and inflammatory mediator release induced by genetically cloned hemolysin-positive and -negative Escherichia coli strains
Q73409285Smooth muscle sarcolemma-associated phospholipase C-beta 2; agonist-evoked translocation
Q68759465Specific binding of phorbol esters to nuclei of human promyelocytic leukemia cells
Q40802230Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis
Q48902292Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.
Q41954007Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes
Q28362699Stimulation of porcine jejunal ion secretion in vivo by protein kinase-C activators
Q28362531Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells
Q36667470Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta
Q70126009Stimulus-dependent mobilization of protein kinase C
Q48766794Stress persistently increases NMDA receptor-mediated binding of [3H]PDBu (a marker for protein kinase C) in the amygdala, and re-exposure to the stressful context reactivates the increase
Q30838837Structure and genomic organization of porcine RACK1 gene
Q48469489Supplementation of the phosphatidyl-L-serine requirement of protein kinase C with nonactivating phospholipids
Q43430886Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia
Q41994316Susceptibility of protein kinase C to oxidative inactivation: loss of both phosphotransferase activity and phorbol diester binding
Q37405255Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner
Q36287281Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
Q43235916Synaptic activity-related classical protein kinase C isoform localization in the adult rat neuromuscular synapse
Q39508598T-lymphocyte activation: the role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway
Q41093301Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells
Q39747239Terminal transferase in normal and leukemic cells
Q28282007The HIV nef protein associates with protein kinase C theta
Q22254235The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1
Q44196251The activation of calcium/phospholipid dependent protein kinase and the association with interleukin-2 production
Q41497512The effect of phorbol ester treatment on migration of C3H 10T1/2 and BT5C glioma cells: possible application to carcinogenesis
Q39820039The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells.
Q37239605The life and death of protein kinase C.
Q57011130The phorbol ester, TPA inhibits glucagon-stimulated adenylate cyclase activity
Q39574025The protein F1/protein kinase C module and neurite growth: potential pathway for facilitating brain transplantation
Q72736250The role of T3 in the activation of human T cells
Q41976770The role of hydrophobic interactions in the phospholipid-dependent activation of protein kinase C.
Q39501206The role of phosphoinositides in signal transduction
Q42857955The role of protein kinase C in the inactivation of hepatic glycogen synthase by calcium-mobilizing agonists
Q39557519The role of protein phosphorylation in the control of cell growth and differentiation
Q77483361The sevenfold way of PKC regulation
Q37363057The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
Q40244889The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells
Q42371610Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents
Q36259155Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis
Q48724500Transient translocation of conventional protein kinase C isoforms and persistent downregulation of atypical protein kinase Mzeta in long-term depression
Q70178064Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils
Q42867355Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin
Q48254521Translocation of protein kinase C in anterior pituitary tumor cells
Q37401275Translocation of protein kinase C in human leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate 13-acetate
Q68257151Translocation of protein kinase C in porcine thyroid cells following exposure to thyrotropin
Q44813368Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation
Q41834541Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores
Q36546242Transmitter release: target of regulation by protein kinase C?
Q37483919Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis
Q59066103Tumour promoters:Protein kinase, phospholipid and control of growth
Q69638209Two isozymes of PKC found in HL-60 cells show a difference in activation by the phorbol ester TPA
Q90547072Unifying principles of bifunctional, proximity-inducing small molecules
Q48831062Unique phosphorylation of protein kinase C-alpha in PC12 cells induces resistance to translocation and down-regulation
Q34781362Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells
Q40420317Upstream regions of the c-jun promoter regulate phorbol ester-induced transcription in U937 leukemic cells
Q24529582Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets
Q43829861Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation
Q41306066Visualization of protein kinase activities in single cells by antibodies against phosphorylated vimentin and GFAP.
Q45065595Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling
Q34276215Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets
Q33654586d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties
Q42581788deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
Q41125691epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury