Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

article by Elizabeth A Kennedy et al published 2018 in Frontiers in Physiology

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHYS.2018.01534
P932PMC publication ID6220354
P698PubMed publication ID30429801

P50authorMegan T BaldridgeQ56741575
P2093author name stringKatherine Y King
Elizabeth A Kennedy
P2860cites workMicrobial modulation of energy availability in the colon regulates intestinal transitQ42449013
Commensal microbiota alter the abundance and TCR responsiveness of splenic naïve CD4+ T lymphocytesQ42486543
How free of germs is germ-free? Detection of bacterial contamination in a germ free mouse unitQ43206463
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiotaQ46167903
Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.Q46326058
ATP drives lamina propria T(H)17 cell differentiationQ46419573
The microbiota protects against respiratory infection via GM-CSF signalingQ47097999
Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiotaQ47430967
Interactions between the microbiota and innate and innate-like lymphocytes.Q47552015
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota.Q48306782
Compartmentalized control of skin immunity by resident commensalsQ24603475
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interfaceQ24644721
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic RodentsQ26795699
Immune-microbiota interactions in health and diseaseQ26827944
Impact of the gut microbiota, prebiotics, and probiotics on human health and diseaseQ26830040
Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small IntestineQ28543424
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisQ29547656
Induction of colonic regulatory T cells by indigenous Clostridium speciesQ29547701
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune systemQ29614267
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisQ29616351
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviourQ29617115
Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthmaQ89394603
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell ResponsesQ89448413
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections.Q51335974
Tropism for tuft cells determines immune promotion of norovirus pathogenesis.Q52323120
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.Q52597757
Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury.Q53220696
Short-term Oral Antibiotics Treatment Promotes Inflammatory Activation of Colonic Invariant Natural Killer T and Conventional CD4+ T Cells.Q53841887
Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice.Q54215475
Gut–Brain Axis and Mood Disorder.Q55019020
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumoniaQ56963192
Germ-free mice produce high levels of interferon-gamma in response to infection with Leishmania major but fail to heal lesionsQ58227632
Dynamics of the human gut phageome during antibiotic treatmentQ59350179
Microbiome, pattern recognition receptor function in health and inflammationQ60642687
High endothelial venule morphology and function are inducible in germ-free mice: A possible role for interferon-γQ61863712
Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting functionQ81073587
Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitisQ84749218
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal RemodelingQ89055227
Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility.Q37586495
The germfree murine animal: an important animal model for research on the relationship between gut microbiota and the hostQ37955502
Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.Q38311200
Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree miceQ39291435
Intestinal microbiota promote enteric virus replication and systemic pathogenesisQ39306213
Maternal Antibiotic Treatment Impacts Development of the Neonatal Intestinal Microbiome and Antiviral Immunity.Q39870861
The microbial metabolite desaminotyrosine protects from influenza through type I interferon.Q40107499
Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota.Q40438742
Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis.Q40473201
Phages rarely encode antibiotic resistance genes: a cautionary tale for virome analysesQ40689920
Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer.Q40899510
Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in miceQ41166877
Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor CellsQ41195214
Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning.Q41195942
Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant miceQ41204512
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in miceQ42351778
The response of the lymphatic tissue to the microbial flora. Studies on germfree miceQ42414281
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisQ29619978
Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasisQ30920058
Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communitiesQ31151211
Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in MiceQ33575993
The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal miceQ33591085
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.Q33609732
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneityQ33752333
Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patchesQ33822367
Innate immune recognition of the microbiota promotes host-microbial symbiosisQ33945889
The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free miceQ34082793
Gut microbiota promote hematopoiesis to control bacterial infectionQ34089573
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucusQ34120082
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccinationQ34216832
Bacterial colonization leads to the colonic secretion of RELMβ/FIZZ2, a novel goblet cell-specific proteinQ34274465
Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy.Q34321946
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistQ34326973
Commensal bacteria protect against food allergen sensitizationQ34583618
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficitsQ34596030
An enteric virus can replace the beneficial function of commensal bacteriaQ34641111
Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networksQ34667649
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expressionQ34704203
Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colonQ34714938
Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiotaQ34729475
Microbiota regulates immune defense against respiratory tract influenza A virus infectionQ34750186
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.Q34918999
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surfaceQ35008436
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesisQ35008903
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanismQ35191621
Commensal bacteria regulate thymic Aire expressionQ35231917
Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signalingQ35322800
Antibiotic treatment suppresses rotavirus infection and enhances specific humoral immunity.Q35443349
Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infectionQ35458229
Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteriaQ35580065
Peyer's patch innate lymphoid cells regulate commensal bacteria expansionQ35582872
Antibiotic-Induced Depletion of Murine Microbiota Induces Mild Inflammation and Changes in Toll-Like Receptor Patterns and Intestinal Motility.Q35610417
Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function.Q35611410
Use of Germ-Free Animal Models in Microbiota-Related ResearchQ35648881
MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cellsQ35687488
Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficileQ35691177
MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut MicrobiotaQ35741680
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineQ35760849
Neutrophil ageing is regulated by the microbiomeQ35776946
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial ColonizationQ35829763
Microbiota depletion promotes browning of white adipose tissue and reduces obesityQ35841623
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.Q35861527
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammationQ35874723
The Gut Microbiota Reduces Colonization of the Mesenteric Lymph Nodes and IL-12-Independent IFN-γ Production During Salmonella InfectionQ35886436
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosaQ35904651
Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty AcidsQ36032402
Impact of intestinal microbiota on intestinal luminal metabolome.Q36050216
Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 ResponseQ36081679
The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the MicrobiomeQ36108549
The gut microbiota regulates bone mass in miceQ36153190
Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion InjuryQ36215448
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonizationQ36352037
Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantationQ36495202
Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large IntestineQ36891309
Manipulation of the Gut Microbiota Reveals Role in Colon TumorigenesisQ36891360
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.Q36916407
Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasisQ36920454
Commensal bacteria calibrate the activation threshold of innate antiviral immunityQ36921389
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenomeQ37009655
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cellsQ37013654
Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injuryQ37391313
Gut microbiota induce IGF-1 and promote bone formation and growthQ37451310
Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in miceQ37514864
Role of antibiotics and fungal microbiota in driving pulmonary allergic responsesQ37521749
The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent mannerQ37581353
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectantibioticQ12187
P304page(s)1534
P577publication date2018-01-01
P1433published inFrontiers in PhysiologyQ2434141
P1476titleMouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria
P478volume9