Access to high-impact mutations constrains the evolution of antibiotic resistance in soft agar

scientific article published in Scientific Reports

Access to high-impact mutations constrains the evolution of antibiotic resistance in soft agar is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-018-34911-9
P932PMC publication ID6242871
P698PubMed publication ID30451932

P50authorBrandon L FindlayQ93208988
P2093author name stringNour Ghaddar
Mona Hashemidahaj
P2860cites workConstruction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
Spatiotemporal microbial evolution on antibiotic landscapesQ26844386
Bacterial Responses and Genome Instability Induced by Subinhibitory Concentrations of AntibioticsQ27008535
The complete genome sequence of Escherichia coli K-12Q27860542
A constant rate of spontaneous mutation in DNA-based microbesQ28271032
Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimuriumQ50127629
A theoretical examination of the relative importance of evolution management and drug development for managing resistance.Q51015217
Growth rates made easy.Q51147152
Predicting drug resistance evolution: insights from antimicrobial peptides and antibiotics.Q52655481
Role of mutator alleles in adaptive evolution.Q54564129
Death and population dynamics affect mutation rate estimates and evolvability under stress in bacteria.Q55162233
Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant CellsQ59444106
Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers setQ77465460
Acceleration of emergence of bacterial antibiotic resistance in connected microenvironmentsQ84975610
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapyQ28544732
Quantifying the Determinants of Evolutionary Dynamics Leading to Drug ResistanceQ28551034
Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classesQ28597744
On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient.Q30519515
Determining the limits of the evolutionary potential of an antibiotic resistance geneQ30912402
Critical evaluation of two primers commonly used for amplification of bacterial 16S rRNA genesQ33320960
Resistance to trimethoprim-sulfamethoxazoleQ33945728
Fitness cost of chromosomal drug resistance-conferring mutationsQ34107494
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutantsQ34370243
Antibiotic resistance-the need for global solutionsQ34386251
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substancesQ34750112
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.Q34922438
Normal mutation rate variants arise in a Mutator (Mut S) Escherichia coli population.Q34998550
Migration of chemotactic bacteria in soft agar: role of gel concentrationQ35132792
Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica.Q35165526
Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibioticsQ35215053
Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistanceQ35699612
Development of potent in vivo mutagenesis plasmids with broad mutational spectraQ36249749
Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitalsQ36333597
Evolutionary paths to antibiotic resistance under dynamically sustained drug selectionQ36500996
AmpC beta-lactamasesQ37366249
Bacterial hypermutation: clinical implicationsQ37847007
The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwideQ38220361
Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosomeQ38355288
LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli.Q38364145
Prediction of antibiotic resistance: time for a new preclinical paradigm?Q38649580
One ring to rule them all: Current trends in combating bacterial resistance to the β-lactamsQ38712471
Evolution of Resistance to Continuously Increasing Streptomycin Concentrations in Populations of Escherichia coliQ38740945
The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of BacteriaQ39019848
Antibiotic uptake into gram-negative bacteriaQ39309521
Two complementation groups mediate tetracycline resistance determined by Tn10Q39984225
Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coliQ40230898
Selective compartments for resistant microorganisms in antibiotic gradientsQ40885917
Mutational Consequences of Ciprofloxacin in Escherichia coliQ41194789
Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolutionQ42054011
High mutation frequencies among Escherichia coli and Salmonella pathogensQ48057867
The Search for 'Evolution-Proof' AntibioticsQ49391302
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibiotic resistanceQ380775
P304page(s)17023
P577publication date2018-11-19
P1433published inScientific ReportsQ2261792
P1476titleAccess to high-impact mutations constrains the evolution of antibiotic resistance in soft agar
P478volume8

Search more.