Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

scientific article published on 29 November 2018

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1007465
P932PMC publication ID6289448
P698PubMed publication ID30496325

P50authorToru TakimotoQ93366809
P2093author name stringTsuyoshi Hayashi
Netty Santoso
Chutikarn Chaimayo
Megan Dunagan
P2860cites workMolecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.Q54217744
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.Q35915706
Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virusQ36363892
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.Q36668024
Viral stress-inducible genes.Q36926779
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30Q37070609
Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff ActivityQ37174404
The known unknowns of antigen processing and presentation.Q37222227
The role of the influenza virus RNA polymerase in host shut-offQ37823112
Viral subversion of the host protein synthesis machineryQ37946208
Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translationQ38288951
Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 proteinQ38715617
Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcriptionQ39646325
Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cellsQ39781908
PA-X protein contributes to virulence of triple-reassortant H1N2 influenza virus by suppressing early immune responses in swineQ40205634
Cholesterol reducing agents inhibit assembly of type I parainfluenza virusesQ40424878
Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity.Q40871573
Lambda interferon is the predominant interferon induced by influenza A virus infection in vivoQ42411048
Impact of influenza PA-X on host responseQ43000411
Immunomodulatory Nonstructural Proteins of Influenza A VirusesQ47548714
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IQ24312113
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
Sendai virus infection induces efficient adaptive immunity independently of type I interferonsQ24545838
The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cellsQ24676166
Structural basis for suppression of a host antiviral response by influenza A virusQ27651800
Functions of the influenza A virus NS1 protein in antiviral defenseQ28083893
The multifunctional NS1 protein of influenza A virusesQ28294201
Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitroQ28391423
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNASQ28609773
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humansQ29619059
Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act.Q30353100
The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.Q30353557
The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.Q30371441
Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune ResponsesQ30373511
PA-X is a virulence factor in avian H9N2 influenza virus.Q30378192
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathwaysQ30380125
Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 proteinQ30388846
The pathogenesis of influenza virus infections: the contributions of virus and host factorsQ30405941
Innate immunity to influenza virus infectionQ33923354
Towards a systems understanding of MHC class I and MHC class II antigen presentation.Q34029353
Interferon-stimulated genes: a complex web of host defensesQ34405609
Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNAQ34629197
Influenza virus non-structural protein NS1: interferon antagonism and beyond.Q35237056
PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host responseQ35640905
Interferon-stimulated genes and their antiviral effector functionsQ35742006
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAsQ35837862
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesDESeq2Q113018293
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e1007465
P577publication date2018-11-29
P1433published inPLOS PathogensQ283209
P1476titleSpecificity and functional interplay between influenza virus PA-X and NS1 shutoff activity
P478volume14

Reverse relations

cites work (P2860)
Q96301394Fated for decay: RNA elements targeted by viral endonucleases
Q90736243Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses
Q101337845Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expression
Q64059156PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection
Q100524034PA-X protein of H5N1 avian influenza virus inhibits NF-kappaB activity, a potential mechanism for PA-X counteracting the host innate immune responses
Q90244937R195K mutation in the PA-X protein increases the virulence and transmission of influenza A virus in mammalian hosts
Q64107548The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression

Search more.