PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection

scientific article published on 10 May 2019

PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-43632-6
P932PMC publication ID6510759
P698PubMed publication ID31076606

P50authorRachel E RigbyQ54377958
Jan RehwinkelQ28152068
P2093author name stringPaul Digard
Helen M Wise
Nikki Smith
P2860cites workInhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusQ24311228
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IQ24312113
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7Q24533409
ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3' RACE applicationsQ24617775
A diverse range of gene products are effectors of the type I interferon antiviral responseQ24626018
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5Q24648192
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling.Q51336057
PA-X: a key regulator of influenza A virus pathogenicity and host immune responsesQ56563872
Viral Infections Activate Types I and III Interferon Genes through a Common MechanismQ56880076
TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral PathwayQ57018246
Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine virusesQ58089550
Host Shutoff in Influenza A Virus: Many Means to an EndQ58762417
Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activityQ59349563
Influenza Virus NS1 Protein RNA-Interactome Reveals Intron TargetingQ59351862
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7Q77758397
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in HumansQ100693613
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTSQ107473800
Cytosolic sensing of virusesQ26852473
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
Functions of the influenza A virus NS1 protein in antiviral defenseQ28083893
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathwayQ28216760
IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genesQ28245089
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IQ28269604
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAQ28513215
Cell type-specific involvement of RIG-I in antiviral responseQ29615914
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.Q30371441
Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune ResponsesQ30373511
PA-X is a virulence factor in avian H9N2 influenza virus.Q30378192
Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.Q30398067
Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potentialQ30417679
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 proteinQ33810694
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferonQ34055501
RIG-I detects viral genomic RNA during negative-strand RNA virus infectionQ34097840
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencingQ34136483
Animal Models for Influenza Virus Pathogenesis and TransmissionQ34714853
PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host responseQ35640905
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.Q35915706
Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virusQ36363892
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virusQ36974640
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.Q37401277
Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity.Q38964354
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferonQ39593618
Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A VirusQ40150668
Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host FitnessQ40198041
PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in miceQ40706208
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrityQ42153057
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virusQ42812948
Interferon Lambda Genetics and Biology in Regulation of Viral ControlQ47141979
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
P304page(s)7216
P577publication date2019-05-10
P1433published inScientific ReportsQ2261792
P1476titlePA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection
P478volume9

Reverse relations

cites work (P2860)
Q90244937R195K mutation in the PA-X protein increases the virulence and transmission of influenza A virus in mammalian hosts
Q102072412The role of PA-X C-terminal 20 residues of classical swine influenza virus in its replication and pathogenicity

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