Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps

scientific article published on 16 August 2018

Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/BIES.201800086
P932PMC publication ID6371793
P698PubMed publication ID30113067

P2093author name stringTom J Brett
Kayla N Berry
Daniel L Kober
Alvin Su
P2860cites workSpecies-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2Q21559418
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherinQ24294470
HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactionsQ24296630
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1Q24297949
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanismsQ24302747
Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomainQ24306855
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interactionQ24309134
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherinQ24318564
A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cellsQ24319113
BST-2/tetherin: a new component of the innate immune response to enveloped virusesQ24630382
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanismQ24644811
HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomesQ24646984
Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirusQ24650331
Inhibition of Lassa and Marburg virus production by tetherinQ24652263
Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection.Q24701738
The role of BST-2/Tetherin in host protection and disease manifestationQ26752737
Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particlesQ27316022
Three-Dimensional Structural Characterization of HIV-1 Tethered to Human CellsQ27321247
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformationsQ27664759
Structural insight into the mechanisms of enveloped virus tethering by tetherinQ27664987
Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus ReleaseQ27665937
Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cellsQ28384647
Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membraneQ28472771
Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interactionQ28478446
Mechanism of HIV-1 virion entrapment by tetherinQ28534707
Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topologyQ28580409
Counteraction of the multifunctional restriction factor tetherinQ28659945
Tetherin inhibits retrovirus release and is antagonized by HIV-1 VpuQ29547836
The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu proteinQ29619540
The BAR domain superfamily: membrane-molding macromoleculesQ30014845
The Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract.Q30235334
Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.Q30376050
Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.Q30382590
Influenza antivirals currently in late-phase clinical trialQ30398099
Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal traffickingQ33455505
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartmentQ33553369
Dimerization of the transmembrane domain of human tetherin in membrane mimetic environmentsQ45093134
B49, a BST-2-based peptide, inhibits adhesion and growth of breast cancer cells.Q52663561
Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in the Naive Mouse, but a Promiscuous Cell Surface Antigen following IFN StimulationQ57275870
Tetherin: Holding On and Letting GoQ58668771
Modulation of the NF-κB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonismQ59352162
High-throughput assay to identify inhibitors of Vpu-mediated down-regulation of cell surface BST-2Q84581960
Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cellsQ38968050
Respiratory RNA VirusesQ38977783
BST-2 restricts IAV release and is countered by the viral M2 protein.Q39021012
BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surfaceQ39034818
BST-2 expression in human hepatocytes is inducible by all three types of interferons and restricts production of hepatitis C virusQ39062893
Antiviral TreatmentsQ39118405
The molecular basis for differential type I interferon signalingQ39176574
Stimulation of NF-κB activity by the HIV restriction factor BST2.Q39230459
Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses.Q39243642
Release of filamentous and spherical influenza A virus is not restricted by tetherinQ39409944
Budding capability of the influenza virus neuraminidase can be modulated by tetherinQ39611736
HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartmentQ39696123
Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoproteinQ39801517
Cooperation of the Ebola proteins VP40 and GP1,2 with BST2 to activate NF-κβ independently of virus-like particle trapping.Q40040462
Influenza Vaccine Effectiveness in the United States during the 2015-2016 SeasonQ40089214
Tetherin antagonism by V proteins is a common trait among the genus RubulavirusQ40217772
Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removalQ40359568
Human parainfluenza virus type 2 V protein inhibits and antagonizes tetherinQ40868468
Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes.Q41544565
Retroviral retention activates a Syk-dependent HemITAM in human tetherin.Q41743410
Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness.Q41922217
Role of viral infections in the development and exacerbation of asthma in childrenQ41922224
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human CellsQ41927179
Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferonsQ42010307
A novel peptide to disrupt the interaction of BST-2 and Vpu.Q42228500
Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherinQ42979548
The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherinQ33564429
Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retrovirusesQ33826655
CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infectionQ33826740
BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1)Q33861091
Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cellsQ33862227
Tetherin inhibits HIV-1 release by directly tethering virions to cellsQ34019962
IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathwayQ34256897
Antagonism to human BST-2/tetherin by Sendai virus glycoproteinsQ34331538
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cellsQ34405097
Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activitiesQ34426491
Nef proteins from simian immunodeficiency viruses are tetherin antagonists.Q34658653
A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus releaseQ34929498
Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infectionQ35076983
Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic CellsQ35690771
The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle releaseQ35826562
Virus-activated interferon regulatory factor 7 upregulates expression of the interferon-regulated BST2 gene independently of interferon signalingQ35826825
Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus InfectionQ35840924
Influenza virus partially counteracts restriction imposed by tetherin/BST-2.Q36052469
HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3.Q36080904
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation InterferenceQ36281167
A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.Q36376142
IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN.Q36463634
2-thio-6-azauridine inhibits Vpu mediated BST-2 degradationQ36646086
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk childrenQ36915476
Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.Q37115285
The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthmaQ37244199
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptinQ37257389
Tetherin is an exosomal tetherQ37276774
Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherinQ37385830
Modulation of an ectodomain motif in the influenza A virus neuraminidase alters tetherin sensitivity and results in virus attenuation in vivoQ37658537
BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factorQ38070284
Human parainfluenza virus type 2 V protein inhibits induction of tetherinQ38813353
Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism.Q38823675
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
respiratory tract infectionQ754447
P304page(s)e1800086
P577publication date2018-08-16
2018-10-01
P1433published inBioEssaysQ4914614
P1476titleLimiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps
P478volume40

Reverse relations

cites work (P2860)
Q90204208Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response
Q90631880Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, in Campylobacter Jejuni-Lysate-Infected U937 Cells

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