Tetherin inhibits HIV-1 release by directly tethering virions to cells

scientific article

Tetherin inhibits HIV-1 release by directly tethering virions to cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELL.2009.08.039
P932PMC publication ID2844890
P698PubMed publication ID19879838
P5875ResearchGate publication ID38058097

P50authorMarc C JohnsonQ60374298
Paul BieniaszQ54632854
P2093author name stringTrinity Zang
David Perez-Caballero
Matthew W McNatt
Devon A Gregory
Alaleh Ebrahimi
P2860cites workSpecies-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2Q21559418
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherinQ24318564
Antiviral actions of interferonsQ24550676
Inhibition of Lassa and Marburg virus production by tetherinQ24652263
Plasma membrane is the site of productive HIV-1 particle assemblyQ27334953
HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egressQ28207991
Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylaseQ28570907
Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topologyQ28580409
Tetherin inhibits retrovirus release and is antagonized by HIV-1 VpuQ29547836
The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu proteinQ29619540
Retrovirus buddingQ29619900
HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membraneQ30815492
Quantitative membrane proteomics reveals new cellular targets of viral immune modulatorsQ33269787
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variantsQ33408799
Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cellsQ33862227
Nef proteins from simian immunodeficiency viruses are tetherin antagonists.Q34658653
Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletionQ37115275
Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.Q37115285
Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu.Q37120188
Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi networkQ37157197
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factorQ39872885
An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu proteinQ40051211
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
virionQ1757347
identical protein bindingQ14762994
Bone marrow stromal cell antigen 2Q21100505
P304page(s)499-511
P577publication date2009-10-01
P1433published inCellQ655814
P1476titleTetherin inhibits HIV-1 release by directly tethering virions to cells
P478volume139

Reverse relations

cites work (P2860)
Q57252413A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism
Q33292303A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.
Q34220959A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.
Q39350800A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein.
Q67405976A lipid-based partitioning mechanism for selective incorporation of proteins into membranes of HIV particles.
Q36387986A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins
Q34668033A new approach to establish a cell line with reduced risk of endogenous retroviruses.
Q34929498A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release
Q34211506A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo
Q36376142A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.
Q30382586A tail of Tetherin: how pandemic HIV-1 conquered the world.
Q28384647Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cells
Q38692134Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
Q27010123An evolutionary perspective on the broad antiviral specificity of MxA
Q39005453Analysis of determinants in filovirus glycoproteins required for tetherin antagonism
Q39707294Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.
Q30423656Animal models for HIV/AIDS research
Q39898727Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.
Q33553369Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
Q39383826Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts
Q35531194Antibody-mediated enhancement of HIV-1 and HIV-2 production from BST-2/tetherin-positive cells
Q35686784Antiretroviral restriction factors
Q34623866Antiretroviral restriction factors in mice
Q33807551Antiviral activity of the interferon-induced cellular protein BST-2/tetherin
Q24635271Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction
Q34123690Antiviral potency and functional analysis of tetherin orthologues encoded by horse and donkey
Q38489344Apolipoprotein E-dependent differences in innate immune responses of maturing human neuroepithelial progenitor cells exposed to HIV-1.
Q34742397Assembly and replication of HIV-1 in T cells with low levels of phosphatidylinositol-(4,5)-bisphosphate.
Q41816646BST-2 Diminishes HIV-1 Infectivity
Q34905536BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action
Q39667774BST-2 mediated restriction of simian-human immunodeficiency virus
Q33631179BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.
Q24630382BST-2/tetherin: a new component of the innate immune response to enveloped viruses
Q39278440BST-2/tetherin: viral tether, viral sensor or both?
Q39034818BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface
Q21559401BST2/Tetherin enhances entry of human cytomegalovirus
Q35544442BST2/tetherin inhibition of alphavirus exit
Q21559656BST2/tetherin inhibits dengue virus release from human hepatoma cells
Q90015819Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (BST-2)
Q26774878Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses
Q28510187Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo
Q36208162Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge
Q39611736Budding capability of the influenza virus neuraminidase can be modulated by tetherin
Q35562726C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif
Q92487810CD317 Activates EGFR by Regulating Its Association with Lipid Rafts
Q27468925CD317 Promotes the survival of cancer cells through apoptosis-inducing factor
Q34325965CD317/tetherin is an organiser of membrane microdomains
Q33826740CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection
Q37428581CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric molecules
Q34291056Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells
Q39222387Cell-cell transmission allows human T-lymphotropic virus 1 to circumvent tetherin restriction
Q34544718Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.
Q33743176Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.
Q33867470Cloning and characterization of the antiviral activity of feline Tetherin/BST-2
Q37589650Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation
Q36245641Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.
Q104480742Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 Infection
Q95601314Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection
Q41877699Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity.
Q34505213Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV
Q28730542Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene
Q28659945Counteraction of the multifunctional restriction factor tetherin
Q92019600Current advances in HIV vaccine preclinical studies using Macaque models
Q38748567Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells
Q41065951Determinants in HIV-2 Env and tetherin required for functional interaction
Q34416492Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein
Q24629504Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin
Q30360141Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.
Q27316022Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles
Q64949513Distinct Requirements for HIV-1 Accessory Proteins during Cell Coculture and Cell-Free Infection.
Q37701191Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles.
Q28607463Early Vertebrate Evolution of the Host Restriction Factor Tetherin
Q30419742Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir
Q36043214Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin
Q40359568Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal
Q39614822Ebolavirus Replication and Tetherin/BST-2.
Q30397332Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain
Q35067382Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻γ C⁻/⁻ mice in vivo
Q39668496Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.
Q35982916Env-less endogenous retroviruses are genomic superspreaders
Q34408687Epitope tags beside the N-terminal cytoplasmic tail of human BST-2 alter its intracellular trafficking and HIV-1 restriction
Q38158955Equine infectious anemia and equine infectious anemia virus in 2013: a review
Q37547504Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein.
Q34684340Evidence that Vpu modulates HIV-1 Gag-envelope interaction towards envelope incorporation and infectivity in a cell type dependent manner
Q26852372Evolution of foamy viruses: the most ancient of all retroviruses
Q52579749Evolution-guided structural and functional analyses of the HERC family reveals an ancient marine origin and determinants of antiviral activity.
Q28533773Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation
Q47424549FRET Analysis of the Promiscuous yet Specific Interactions of the HIV-1 Vpu Transmembrane Domain
Q38326209Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation.
Q35076983Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection
Q36086707Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein
Q36594734Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression
Q92005460Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
Q57043865From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
Q37336745Functional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions
Q34231846Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties
Q33871635Functional microarray analysis suggests repressed cell-cell signaling and cell survival-related modules inhibit progression of head and neck squamous cell carcinoma
Q34511101HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep
Q35902681HIV Restriction Factors and Mechanisms of Evasion
Q37375080HIV accessory proteins versus host restriction factors
Q37945213HIV-1 Virological Synapse: Live Imaging of Transmission
Q37384691HIV-1 Vpu - an ion channel in search of a job.
Q40677862HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites
Q39175785HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.
Q39696123HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment
Q33887674HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.
Q38281996HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface
Q39536992HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction
Q24296630HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions
Q24619066HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms
Q39417033HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin
Q97886770HM1.24/BST-2 is constitutively poly-ubiquitinated at the N-terminal amino acid in the cytoplasmic domain
Q64078553Herpes Simplex Virus Evasion of Early Host Antiviral Responses
Q42266919Herpes simplex virus 1 counteracts tetherin restriction via its virion host shutoff activity
Q47230024High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release
Q37252004Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches
Q61807398Host and Viral Proteins Modulating Ebola and Marburg Virus Egress
Q37890247Host factors involved in retroviral budding and release.
Q36548179Host restriction factors in retroviral infection: promises in virus-host interaction
Q34298213How Ebola virus counters the interferon system
Q90440626How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection
Q40285743Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain
Q54260280Human Intestinal Epithelial Cells Release Antiviral Factors That Inhibit HIV Infection of Macrophages.
Q30425799Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein
Q31086787Identification and functional analysis of three isoforms of bovine BST-2
Q35792954Identification of BST-2/tetherin-induced hepatitis B virus restriction and hepatocyte-specific BST-2 inactivation
Q35028829Identification of Residues in the BST-2 TM Domain Important for Antagonism by HIV-1 Vpu Using a Gain-of-Function Approach
Q34426491Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities
Q39114721Identification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu
Q41922332Identifying Restriction Factors for Hemorrhagic Fever Viruses: Dengue and Junín
Q28472771Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane
Q34434913Immunogenetics of small ruminant lentiviral infections
Q35382088In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity
Q35170879In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans
Q36270509Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys
Q34405097Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells
Q37385830Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin
Q36052469Influenza virus partially counteracts restriction imposed by tetherin/BST-2.
Q47550785Inhibiting the Ins and Outs of HIV Replication: Cell-Intrinsic Antiretroviral Restrictions at the Plasma Membrane
Q38170229Innate antiviral immune signaling, viral evasion and modulation by HIV-1.
Q51574130Innate barriers to viral infection.
Q33997880Innate immune recognition and activation during HIV infection
Q38160779Innate immune responses to HIV infection in the central nervous system
Q38491184Innate immunity against HIV-1 infection
Q35696991Innate immunity in acute HIV-1 infection
Q39243642Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses.
Q34561070Insights into cellular factors that regulate HIV-1 replication in human cells
Q54478839Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.
Q24302747Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms
Q28585561Interferon-induced tetherin restricts vesicular stomatitis virus release in neurons
Q34114819Interferon-inducible effector mechanisms in cell-autonomous immunity
Q35742006Interferon-stimulated genes and their antiviral effector functions
Q34405609Interferon-stimulated genes: a complex web of host defenses
Q92703239Interplay between Intrinsic and Innate Immunity during HIV Infection
Q33826655Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses
Q37899341Intracellular defenses against HIV, viral evasion and novel therapeutic approaches
Q28659575Intrinsic cellular defenses against human immunodeficiency viruses
Q30954229Intrinsic host restrictions to HIV-1 and mechanisms of viral escape.
Q39538757Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317.
Q38697270Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E.
Q57027519Latent human cytomegalovirus enhances HIV-1 infection in CD34 progenitor cells
Q36807121Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines
Q59354447Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps
Q34885158Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin.
Q42369135Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.
Q40927400MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
Q38282025Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane
Q41927990Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription
Q28534707Mechanism of HIV-1 virion entrapment by tetherin
Q38688274Mechanisms of HIV-1 Control
Q33828507Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers
Q38211428Mechanisms underlying HIV-1 Vpu-mediated viral egress
Q35536281Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly
Q39649986Membrane raft association of the Vpu protein of human immunodeficiency virus type 1 correlates with enhanced virus release
Q30397761Modulation of HIV-1-host interaction: role of the Vpu accessory protein
Q92989829Modulation of Innate Immune Signaling Pathways by Herpesviruses
Q37658537Modulation of an ectodomain motif in the influenza A virus neuraminidase alters tetherin sensitivity and results in virus attenuation in vivo
Q42979548Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin
Q34536269Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses
Q36355811Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy
Q33650914Molecular evolution of the primate antiviral restriction factor tetherin
Q34645914Molecular mechanism of arenavirus assembly and budding
Q47555946Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature
Q36735631Mutation of Glycosylation Sites in BST-2 Leads to Its Accumulation at Intracellular CD63-Positive Vesicles without Affecting Its Antiviral Activity against Multivesicular Body-Targeted HIV-1 and Hepatitis B Virus
Q47141408Myeloid Cell Interaction with HIV: A Complex Relationship.
Q92239576Negative and Positive Selection Pressure During Sexual Transmission of Transmitted Founder HIV-1
Q36307738New insights into HIV assembly and trafficking
Q58698873Nomenclature for endogenous retrovirus (ERV) loci
Q34389186Oligomerization state and supramolecular structure of the HIV‐1 Vpu protein transmembrane segment in phospholipid bilayers
Q40610377Origins and Evolution of tetherin, an Orphan Antiviral Gene.
Q43433320Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin
Q93081405Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
Q33933111Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity
Q59354068Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δ-Infected Animals
Q30369981Positioning of cysteine residues within the N-terminal portion of the BST-2/tetherin ectodomain is important for functional dimerization of BST-2.
Q37820816Properties and functions of the nucleocapsid protein in virus assembly
Q37013972Protective Role of BST2 Polymorphisms in Mother-to-Child Transmission of HIV-1 and Adult AIDS Progression.
Q28478446Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction
Q39084005RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs
Q89777325RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells
Q24296650Rab7A is required for efficient production of infectious HIV-1
Q35030956Regulation of Interferon-Stimulated Gene BST2 by a lncRNA Transcribed from a Shared Bidirectional Promoter
Q34666503Relationships between plasma membrane microdomains and HIV-1 assembly
Q26767362Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence
Q38823675Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism.
Q92646111Resilience of BST-2/Tetherin structure to single amino acid substitutions
Q60046078Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1
Q42234287Restriction of Retroviral Replication by Tetherin/BST-2.
Q37895742Retroviral restriction and dependency factors in primates and carnivores
Q41743410Retroviral retention activates a Syk-dependent HemITAM in human tetherin.
Q84985844Rhesus monkey TRIM5α has distinct HIV-1 restriction activity among different mammalian cell lines
Q35383008Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens
Q36760105Roles played by capsid-dependent induction of membrane curvature and Gag-ESCRT interactions in tetherin recruitment to HIV-1 assembly sites
Q33916620SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release
Q36409352Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range
Q35383228Separable determinants of subcellular localization and interaction account for the inability of group O HIV-1 Vpu to counteract tetherin
Q35531294Sequences in gibbon ape leukemia virus envelope that confer sensitivity to HIV-1 accessory protein Vpu.
Q35758867Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors
Q34146128Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu
Q36281167Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference
Q84315458Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle release
Q35036587Short communication: Nitazoxanide inhibits HIV viral replication in monocyte-derived macrophages
Q37378819Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism.
Q36141193Smart self-assembled hybrid hydrogel biomaterials
Q35383070Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo
Q37335524Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages
Q39230459Stimulation of NF-κB activity by the HIV restriction factor BST2.
Q35607295Structural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral Antagonism
Q27665937Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus Release
Q27664759Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations
Q24306855Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain
Q47155329Structural determinant of BST-2-mediated regulation of breast cancer cell motility: a role for cytoplasmic tail tyrosine residues
Q27664987Structural insight into the mechanisms of enveloped virus tethering by tetherin
Q33740120Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.
Q41849777T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication
Q34144143TIM-family proteins inhibit HIV-1 release.
Q36578830TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse.
Q35076765TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements
Q39654362Tethered virions are intermediates in the assembly and release of HIV-1 particles
Q30393226Tetherin Antagonism by HIV-1 Group M Nef Proteins
Q30853698Tetherin Inhibits Cell-Free Virus Dissemination and Retards Murine Leukemia Virus Pathogenesis
Q30376050Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.
Q37827428Tetherin and its viral antagonists
Q33674461Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity.
Q31172123Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells
Q42746331Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef.
Q37607851Tetherin has negligible activity in restricting hepatitis C virus in hepatocytes
Q59350998Tetherin inhibits Nipah virus but not Ebola virus replication in fruit bat cells
Q35038590Tetherin inhibits prototypic foamy virus release
Q35518677Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo
Q34180302Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.
Q38933327Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins
Q30497822Tetherin restricts direct cell-to-cell infection of HIV-1.
Q37336851Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M
Q27314339Tetherin restricts productive HIV-1 cell-to-cell transmission
Q34819697Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis
Q41990109Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.
Q36548512Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Q30385433Tetherin/BST-2: Restriction Factor or Immunomodulator?
Q33815533The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation
Q35300078The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin
Q35808638The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection
Q34594080The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activity
Q28742774The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism
Q35973592The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion
Q56988192The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies
Q28606741The KT Jeang Retrovirology prize 2015: Paul Bieniasz
Q41504905The Molecular Switch of Telomere Phages: High Binding Specificity of the PY54 Cro Lytic Repressor to a Single Operator Site
Q89804627The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization
Q33564429The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
Q37448307The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies
Q36301264The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD)
Q34594813The VP40 protein of Marburg virus exhibits impaired budding and increased sensitivity to human tetherin following mouse adaptation
Q36824020The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species
Q38269459The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation
Q57050797The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin
Q38321444The cytoplasmic tail of retroviral envelope glycoproteins.
Q41762850The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif.
Q40055431The effect of bovine BST2A1 on the release and cell-to-cell transmission of retroviruses
Q45323651The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells.
Q21090506The great escape: viral strategies to counter BST-2/tetherin
Q34492477The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?
Q24605108The restriction factors of human immunodeficiency virus
Q26752737The role of BST-2/Tetherin in host protection and disease manifestation
Q34664616The role of BST2/tetherin in feline retrovirus infection
Q39010678The roles of ebolavirus glycoproteins in viral pathogenesis.
Q34992656The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions
Q36492793The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release
Q35826562The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release
Q38210024The ubiquitin-conjugating system: multiple roles in viral replication and infection
Q35172704The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy
Q39717911Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication
Q27321247Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells
Q47548056Type I Interferon Responses by HIV-1 Infection: Association with Disease Progression and Control
Q38181142Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1.
Q38348388Type I interferon: understanding its role in HIV pathogenesis and therapy
Q92681960Ubiquitination and SUMOylation in HIV Infection: Friends and Foes
Q31034125Ultra structural characterisation of tetherin - a protein capable of preventing viral release from the plasma membrane
Q92859937Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses
Q35075884Upregulation of innate antiviral restricting factor expression in the cord blood and decidual tissue of HIV-infected mothers.
Q43047324Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles
Q27000898Viral Membrane Channels: Role and Function in the Virus Life Cycle
Q35778560Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-κB Activation
Q35151120Viral miniproteins
Q37755567Viral proteins function as ion channels.
Q90470251Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding
Q38023155Viroporins: structure and biological functions.
Q37726587Virus cell-to-cell transmission.
Q35826825Virus-activated interferon regulatory factor 7 upregulates expression of the interferon-regulated BST2 gene independently of interferon signaling
Q26801489Vpu Protein: The Viroporin Encoded by HIV-1
Q34697856Vpu binds directly to tetherin and displaces it from nascent virions
Q34532245Vpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail
Q84561051Vpu-mediated tetherin antagonism of ongoing HIV-1 infection in CD4(+) T-cells is not directly related to the extent of tetherin cell surface downmodulation
Q35089155Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
Q24336663Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation
Q34312227Zinc-finger antiviral protein inhibits XMRV infection
Q109649533Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/Tetherin
Q39594626β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release
Q57811810βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin

Search more.