Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

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Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1110542091
P356DOI10.1186/S13054-018-2277-5
P932PMC publication ID6288902
P698PubMed publication ID30538005

P50authorAnthony GordonQ57300688
P2093author name stringJames Tomlinson
Sophie Piper
James Leiper
Simon Lambden
P2860cites workWhat is the best method for estimating the burden of severe sepsis in the United States?Q51378498
Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction.Q51789370
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.Q53063266
Myocardial depression characterizes the fatal course of septic shock.Q54269075
Circulatory ShockQ56137044
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunctionQ57773627
High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivoQ73286550
Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial diseaseQ82983436
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminasesQ22010563
Sepsis: rethinking the approach to clinical researchQ22255578
Disruption of methylarginine metabolism impairs vascular homeostasisQ27643718
Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studiesQ28087272
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney DamageQ30300218
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsisQ31001162
Biological significance of endogenous methylarginines that inhibit nitric oxide synthasesQ33847583
Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH).Q33879866
State of the arg: protein methylation at arginine comes of age.Q34084396
Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational studyQ35544768
The DDAH/ADMA/NOS pathwayQ35603929
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shockQ35621102
L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failureQ35961528
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsisQ36083890
Judging quality of current septic shock definitions and criteriaQ36424765
Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyondQ36438224
Nitric oxide in shockQ36835542
Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysisQ37819904
Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical TrialQ38389309
Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertensionQ38462560
High Levels of Methylarginines Were Associated With Increased Mortality in Patients With Severe SepsisQ39749294
Regulation of biosynthesis of nitric oxide.Q40389134
Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene StudyQ40397164
Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and LimitationsQ40491993
Markers of nitric oxide are associated with sepsis severity: an observational studyQ41033479
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphismsQ43221823
Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertensionQ43295548
Relationship between circulating levels of calcitonin gene-related peptide, nitric oxide metabolites and hemodynamic changes in human septic shockQ44011999
Microvascular blood flow is altered in patients with sepsisQ44045816
Nitrite/nitrate oxide (NOx) and cytokine levels in patients with septic shockQ44723750
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsisQ44901088
Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.Q45967633
Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in ratsQ46661250
Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE studyQ46770081
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failureQ46861533
Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary originsQ47663251
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectsingle-nucleotide polymorphismQ501128
septic shockQ1765564
P304page(s)336
P577publication date2018-12-11
P1433published inCritical CareQ5186602
P1476titleEvidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity
P478volume22