Nitric oxide in shock

scientific article published on 30 May 2007

Nitric oxide in shock is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.KI.5002340
P698PubMed publication ID17538569
P5875ResearchGate publication ID6296844

P2093author name stringCauwels A
P2860cites workRole of endothelium-derived nitric oxide in the regulation of blood pressureQ28242958
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
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Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginineQ67537698
NG-monomethyl-l-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shockQ67945286
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radicalQ69908799
Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbitsQ71580286
Effects of a nitric oxide synthase inhibitor in humans with septic shockQ71611483
Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusionQ71775893
Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activityQ72102328
cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cellsQ72848651
Effects of carboxy-PTIO on systemic hemodynamics, liver energetics, and concentration of liver metabolites during endotoxic shock in rabbits: a 31P and 1H magnetic resonance spectroscopic studyQ73454343
Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbateQ73643093
Nonselective versus selective inhibition of inducible nitric oxide synthase in experimental endotoxic shockQ74005713
Selective NOS inhibition restores myocardial contractility in endotoxemic rats; however, myocardial NO content does not correlate with myocardial dysfunctionQ74025520
Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissuesQ74211165
Prolonged inhibition of nitric oxide synthesis in severe septic shock: a clinical studyQ74480713
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivationQ78038211
Evidence for, and importance of, cGMP-independent mechanisms with NO and NO donors on blood vessels and plateletsQ81243805
Septic shockQ81245367
Potassium channels and septic shockQ82893241
Is nitric oxide overproduction the target of choice for the management of septic shock?Q34463493
Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat.Q34793248
Anaphylaxis: a review of causes and mechanismsQ34810093
cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO.Q34831503
Anaphylactic shock depends on PI3K and eNOS-derived NO.Q34872991
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthaseQ35026148
Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammationQ35052426
Novel strategies for the treatment of sepsisQ35118750
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemiaQ35545028
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shockQ35621102
Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.Q35626892
EDHF: new therapeutic targets?Q35693574
Immune cells: free radicals and antioxidants in sepsis.Q35705224
Acute renal failure and sepsisQ35833149
MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanismsQ36012140
Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxideQ36041762
NO generation from nitrite and its role in vascular controlQ36061188
Novel therapies for sepsis: a reviewQ36095713
cGMP-dependent protein kinases in drug discoveryQ36127830
Cardiovascular aspects of anaphylaxis: implications for treatment and diagnosisQ36178088
Nitric oxide as a modulator of apoptosisQ36187401
N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxinQ36231861
Hydrogen sulfide as a vasodilatorQ36276376
Signaling for contraction and relaxation in smooth muscle of the gut.Q36387902
Endothelium-derived hyperpolarizing factor: where are we now?Q36423629
Severe sepsis and septic shock: review of the literature and emergency department management guidelines.Q36510126
Role of KATP channels in sepsisQ36590110
Therapeutic use of nitric oxide scavengers in shock and sepsisQ36612099
Survival of TNF toxicity: dependence on caspases and NO.Q36744895
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albuminQ37159291
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharideQ37555750
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoproteinQ37587741
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.Q37718172
On the expression of nitric oxide synthase by human macrophages. Why no NO?Q40382556
Human monocytes/macrophages: NO or no NO?Q40752174
Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosisQ41021039
Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid arteryQ42131226
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shockQ42150089
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.Q42484284
EDHF and endothelial potassiun channels: IKCa and SKCaQ43178704
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesisQ43540421
The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shockQ43707175
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled studyQ43757721
Continuously infused methylene blue modulates the early cardiopulmonary response to endotoxin in awake sheepQ43817592
Differential involvement of guanylate cyclase and potassium channels in nitric oxide-induced hyporesponsiveness to phenylephrine in endotoxemic ratsQ43857378
Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivoQ44121526
Does methylene blue administration to septic shock patients affect vascular permeability and blood volume?Q44190542
Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shockQ44296580
Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.Q44315300
Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shockQ44618408
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxideQ45111036
Effect of potassium channel and cytochrome P450 inhibition on transient hypotension and survival during lipopolysaccharide-induced endotoxic shock in the rat.Q45119665
An inhibitor of nitric oxide production, NGnitro-L-arginine-methyl ester, improves survival in anaphylactic shockQ45180812
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.Q45256231
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouseQ46465914
Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stressQ46577764
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Q46738154
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouseQ46905143
Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shockQ46949999
NO contest: nitrite versus S-nitroso-hemoglobinQ47755076
Expression of inducible nitric oxide synthase in circulating neutrophils of the systemic inflammatory response syndrome and septic patientsQ47804605
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock.Q48639311
Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shockQ49072068
Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthaseQ49073437
Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or bothQ50126739
Methylene blue: an old-timer or a compound ready for revival?Q50474866
Effects of methylene blue on oxygen availability and regional blood flow during endotoxic shockQ50757928
Methylene blue administration in septic shock: a clinical trial.Q50764693
Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin.Q50772503
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle.Q50773580
Inhibition of nitric oxide synthesis by methylene blueQ50785727
Methylene blue increases systemic vascular resistance in human septic shock. Preliminary observationsQ50797195
Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury.Q50802519
Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice.Q51445046
Nitric oxide synthase activity is increased in patients with sepsis syndrome.Q52870839
Effects of nitric oxide scavenger, carboxy-PTIO on endotoxin-induced alterations in systemic hemodynamics in rats.Q54045111
NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension.Q54171009
Glibenclamide, a blocker of ATP-sensitive potassium channels, reverses endotoxin-induced hypotension in pig.Q54186651
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?Q54355366
In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.Q54459009
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)557-565
P577publication date2007-05-30
P1433published inKidney InternationalQ6404823
P1476titleNitric oxide in shock
P478volume72

Reverse relations

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