A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats

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A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1742-7843.2009.00501.X
P932PMC publication ID2882512
P698PubMed publication ID20002062
P5875ResearchGate publication ID40679979

P2093author name stringKafait U Malik
Bahar Tunctan
Belma Korkmaz
C Kemal Buharalioglu
John Falck
Seyhan Sahan-Firat
Tuba Cuez
P2860cites workNitric oxide and vascular reactivity in sepsis.Q46428848
Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.Q46804513
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenaseQ48493776
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A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock.Q54461995
Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide.Q54583287
Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress?Q57216536
20-HETE agonists and antagonists in the renal circulationQ57220278
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Inhibition of 20-HETE production contributes to the vascular responses to nitric oxideQ57221409
Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysacchride treatment in vivo in the ratQ61712889
20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteriesQ70781584
Cytochrome P450-derived renal HETEs: storage and releaseQ73423928
20-HETE relaxes bovine coronary arteries through the release of prostacyclinQ74132575
Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in ratsQ80380690
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertensionQ80428271
Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthaseQ24307745
Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vesselQ28189283
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expressionQ28243109
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivoQ28505758
P-450 metabolites of arachidonic acid in the control of cardiovascular functionQ29620578
The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signalingQ31838704
20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells.Q34276074
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolitesQ34428688
Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular systemQ34463893
Functional significance of hsp90 complexes with NOS and sGC in endothelial cellsQ34653954
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.Q34729787
Regulation of the expression of inducible nitric oxide synthase.Q35605774
Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donorsQ36138113
Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studiesQ36203883
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Endothelial nitric oxide (NO) and its pathophysiologic regulationQ36992714
A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.Q37041257
Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.Q37199203
Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.Q40185278
Effects of a 20-HETE antagonist and agonists on cerebral vascular toneQ42457671
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.Q42484284
Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteriesQ44138643
Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.Q44315300
20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinaseQ44353853
Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant ratsQ44396063
In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOQ44671163
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirusQ44739223
autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function.Q45176603
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.Q45819815
Negative feedback regulation of endothelial cell function by nitric oxideQ46053566
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectendotoxinsQ319997
P304page(s)378-388
P577publication date2009-12-07
P1433published inBasic and Clinical Pharmacology and ToxicologyQ15724438
P1476titleA synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats
P478volume106

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cites work (P2860)
Q370858445,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.
Q47348893Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock.
Q40792305Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock
Q37138417Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock
Q35084210Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.
Q34151380Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.
Q51025124Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms.
Q37174392NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite
Q35173157Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide
Q35710923Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats.
Q38100223Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.

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