Human D-Amino Acid Oxidase: Structure, Function, and Regulation

scientific article published on 28 November 2018

Human D-Amino Acid Oxidase: Structure, Function, and Regulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FMOLB.2018.00107
P932PMC publication ID6279847
P698PubMed publication ID30547037

P50authorGiulia MurtasQ54963175
Loredano PollegioniQ28359654
P2093author name stringSilvia Sacchi
P2860cites workDisseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's diseaseQ48268722
Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidaseQ48305063
Involvement of the primate specific gene G72 in schizophrenia: From genetic studies to pathomechanismsQ48324392
An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of NeuronsQ48348242
Involvement of D-amino acid oxidase in elimination of D-serine in mouse brainQ48444964
Age-related effects of the neuromodulator D-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat.Q48491445
Regional distribution and postnatal changes of D-amino acids in rat brainQ48763751
Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidaseQ48857138
Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.Q48925158
D-Amino Acid Oxidase-pLG72 Interaction and D-Serine Modulation.Q50127100
Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of SchizophreniaQ22241679
d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophreniaQ24294371
Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesisQ24297316
A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinitiesQ24300660
Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell lineQ24306641
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaQ24308818
Relevance of weak flavin binding in human D-amino acid oxidaseQ24309227
Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatmentQ24316880
Characterization of human D-amino acid oxidaseQ24317569
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibilityQ24320365
NMDA Receptor Function During Senescence: Implication on Cognitive PerformanceQ26770902
Sites of binding and orientation in a four-location model for protein stereospecificityQ27625401
The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenationQ27628036
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.Q50482411
Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.Q50998776
Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access.Q55283538
Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies.Q55340063
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.Q55717695
Immunocytochemical localization of D-amino acid oxidase in rat brainQ58236646
The role of cofactor binding in tryptophan accessibility and conformational stability of His-tagged d-amino acid oxidase from Trigonopsis variabilisQ59385642
Localization of D-amino acid oxidase mRNA in the mouse kidney and the effect of testosterone treatmentQ70934129
Characterization of D-amino acid oxidase from Trigonopsis variabilisQ72666242
D-amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytesQ72788226
Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammalsQ73131335
Nephrotoxicity of D-proparglyglycine in miceQ73245807
Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine antinociceptive toleranceQ87223869
Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophreniaQ94704034
Yeast D-amino acid oxidase: structural basis of its catalytic propertiesQ27640004
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitorsQ27655460
Novel human ᴅ-amino acid oxidase inhibitors stabilize an active-site lid-open conformationQ27684575
Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2Q27733284
Increased brain D-amino acid oxidase (DAAO) activity in schizophreniaQ28274560
Physiological functions of D-amino acid oxidases: from yeast to humansQ28295729
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activityQ28513330
A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memoryQ28571166
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmissionQ28590312
BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacologyQ28603124
Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidaseQ31680371
The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Q33611796
Activity of D-amino acid oxidase is widespread in the human central nervous systemQ33730910
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidaseQ33842154
Neurobiology through the looking-glass: D-serine as a new glial-derived transmitterQ33960838
Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.Q33966453
Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patientsQ33987618
D-amino acids in the central nervous system in health and diseaseQ33988102
Metabolism of amino-acids: Deamination of amino-acidsQ33996419
Glutamate and schizophrenia: beyond the dopamine hypothesisQ33996803
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).Q33997506
Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective?Q34003528
Mouse mutant deficient in D-amino acid oxidase activityQ34005267
Metabolism of the neuromodulator D-serine.Q34021473
The role of D-amino acids in amyotrophic lateral sclerosis pathogenesis: a reviewQ34033121
Drug discovery targeting amino acid racemasesQ34215943
Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivoQ34286452
d-serine levels in Alzheimer's disease: implications for novel biomarker developmentQ34475073
Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity.Q43648615
Assignment of D-amino-acid oxidase gene to a human and a mouse chromosomeQ43673577
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cellsQ44131370
Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat.Q44590316
Structure-function correlation in glycine oxidase from Bacillus subtilis.Q44856933
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic painQ45780324
Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection.Q45935284
Optimization of human D-amino acid oxidase expression in Escherichia coli.Q45982397
Synthesis and biological evaluation of D-amino acid oxidase inhibitors.Q46572073
D-amino-acid oxidase is involved in D-serine-induced nephrotoxicityQ46813951
Competitive Inhibitors Unveil Structure/Function Relationships in Human D-Amino Acid OxidaseQ47117950
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neuronsQ47118571
Human d-amino acid oxidase: The inactive G183R variantQ47258168
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult targetQ47681604
Biochemical Properties of Human D-Amino Acid Oxidase.Q47868455
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitroQ48172184
d-Amino Acid Levels in Perfused Mouse Brain Tissue and Blood: A Comparative StudyQ48229603
L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neuronsQ35313612
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathwaysQ35624305
Expanding the chemical space of human serine racemase inhibitorsQ35748414
Protective role of D-amino acid oxidase against Staphylococcus aureus infectionQ35867584
Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivoQ35951912
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic painQ36025408
Localization of D-amino acid oxidase on the cell surface of human polymorphonuclear leukocytesQ36199108
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenonQ36357444
D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial systemQ36450594
Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring.Q36458171
Novel targets for drugs in schizophreniaQ36907403
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidaseQ36917482
Human D-amino acid oxidase: an update and review.Q36965925
Properties and applications of microbial D-amino acid oxidases: current state and perspectivesQ37033904
D-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brainQ37118079
Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiotaQ37357830
Central sensitization: a generator of pain hypersensitivity by central neural plasticityQ37361185
Serine racemase and the serine shuttle between neurons and astrocytesQ37827616
New biotech applications from evolved D-amino acid oxidases.Q37852361
Structure-function relationships in human D-amino acid oxidase.Q38032223
The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration.Q38164385
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.Q38672905
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibilityQ38717701
G72 primate-specific gene: a still enigmatic element in psychiatric disordersQ38749650
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPsQ38907627
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.Q39062810
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.Q39230935
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interactionQ39613722
In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic propertiesQ40097342
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cellsQ40349429
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase InhibitorQ40618357
Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategiesQ41619176
Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomersQ41898653
A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.Q42856729
D-amino acid oxidase activity and expression are increased in schizophrenia.Q43195422
Spinal D-amino acid oxidase contributes to neuropathic pain in ratsQ43261398
Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brainQ43291010
The presence of free D-serine, D-alanine and D-proline in human plasmaQ43586675
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)107
P577publication date2018-11-28
P1433published inFrontiers in molecular biosciencesQ27726420
P1476titleHuman D-Amino Acid Oxidase: Structure, Function, and Regulation
P478volume5

Reverse relations

Q91675920Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargetingcites workP2860

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