A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

scientific article published in January 2013

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCOMMS2371
P698PubMed publication ID23340406

P2093author name stringKiyoshi Fukui
Shin Koike
Yuki Ogasawara
Yuka Kimura
Hideo Kimura
Mari Ishigami-Yuasa
Noriyuki Nagahara
Makiko Tanaka
Norihiro Shibuya
P2860cites workIdentification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acidsQ22253376
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactionsQ27929768
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel openerQ28363080
Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expressionQ28506768
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brainQ28513550
Characterization of homocysteine metabolism in the rat kidneyQ28568553
Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysisQ28569061
Purification of serine racemase: biosynthesis of the neuromodulator D-serineQ28573657
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial functionQ30480176
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesisQ33733662
Metabolism of amino-acids: Deamination of amino-acidsQ33996419
Origin, microbiology, nutrition, and pharmacology of D-amino acidsQ34022818
Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide.Q34992435
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channelsQ35603720
Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteinsQ36219439
Sulphane sulphur in biological systems: a possible regulatory roleQ38763753
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfideQ39511939
Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondriaQ39784182
L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitterQ40286540
Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanismsQ40369965
Special delivery from mitochondria to peroxisomesQ41452491
Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the ratQ42122753
On the chemistry and biochemistry of 3-mercaptopyruvic acid, the alpha-keto acid analog of cysteine.Q42263136
Hydrogen sulfide enhances reducing activity in neurons: neurotrophic role of H2S in the brain?Q42824880
Hydrogen sulfide induces calcium waves in astrocytes.Q44735803
Hydrogen sulfide protects neurons from oxidative stressQ44904699
Purification and characterization of mitochondrial cysteine aminotransferase from rat liverQ45096122
Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thalianaQ45273424
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunctionQ46446506
The possible role of hydrogen sulfide as an endogenous neuromodulator.Q46606180
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Q46738154
Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidaseQ48305063
L-cysteine, a bicarbonate-sensitive endogenous excitotoxinQ48973772
Is a certain amount of cysteine prerequisite to produce brain damage in neonatal rats?Q69617995
Immunoelectron microscopic localization of D-amino acid oxidase in rat kidney and liverQ69901248
In vivo and in vitro expression of porcine D-amino acid oxidase: in vitro system for the synthesis of a functional enzymeQ69927441
The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the ratQ70968282
Flavoenzyme catalysis: substrate-competitive inhibition of D-amino acid oxidaseQ74300453
Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteineQ77134087
Determination of alpha-keto acids in serum and urine by high-performance liquid chromatography with fluorescence detectionQ93672769
P407language of work or nameEnglishQ1860
P921main subjectD-CysteineQ16633812
P304page(s)1366
P577publication date2013-01-01
P1433published inNature CommunicationsQ573880
P1476titleA novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
P478volume4

Reverse relations

cites work (P2860)
Q416205013-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S.
Q92881645A Fast-Response Red Shifted Fluorescent Probe for Detection of H2S in Living Cells
Q48186286A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications.
Q39325806A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease.
Q92533395A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway
Q62381232A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?
Q38759243A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.
Q55078338A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration.
Q50205191A novel pathway for the production of H2 S by DAO in rat jejunum
Q41904350A simple bioluminescent method for measuring D-amino acid oxidase activity
Q47762321A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator
Q47106415Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
Q28585109Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria
Q38732028Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response.
Q47868455Biochemical Properties of Human D-Amino Acid Oxidase.
Q55340063Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies.
Q35640746Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice
Q37700190Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS).
Q39173063Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis
Q57021829Cavernosal hydrogen sulfide levels are associated with nitric oxide and hemeoxygenase levels in diabetic rats
Q47430972Chemical Biology of H2S Signaling through Persulfidation
Q38121347Chemical foundations of hydrogen sulfide biology
Q38905201Chemiluminescent detection of enzymatically produced H2S
Q91716765CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway
Q37555498Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.
Q41270672Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration
Q35903690Cysteine Metabolism and Oxidative Processes in the Rat Liver and Kidney after Acute and Repeated Cocaine Treatment
Q42147655Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation
Q39067787D-Amino Acids in the Nervous and Endocrine Systems
Q28817472Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
Q58760529Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria?
Q51459204Dual-Reactable Fluorescent Probes for Highly Selective and Sensitive Detection of Biological H2 S.
Q51068380Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice.
Q38165277Emerging role of gasotransmitters in renal transplantation.
Q28078276Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival
Q92929300Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells
Q35204841Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats
Q57812368Gas Signaling Molecules and Mitochondrial Potassium Channels
Q39451528Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury
Q38772779Gasotransmitter Heterocellular Signaling
Q37656625Gasotransmitters in cancer: from pathophysiology to experimental therapy
Q41849370Gasotransmitters: novel regulators of ion channels and transporters.
Q38600019H2S: A Novel Gasotransmitter that Signals by Sulfhydration
Q59805075Human D-Amino Acid Oxidase: Structure, Function, and Regulation
Q46317273Hydrogen Polysulfide Biosignal-Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS).
Q64958643Hydrogen Sulfide Attenuates High Glucose-Induced Human Retinal Pigment Epithelial Cell Inflammation by Inhibiting ROS Formation and NLRP3 Inflammasome Activation.
Q52595127Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.
Q90538033Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
Q49093504Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice
Q54224553Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.
Q64230679Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease
Q54919654Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins.
Q28087344Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract
Q38785627Hydrogen Sulfide in Renal Physiology and Disease
Q92479214Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy
Q38916218Hydrogen polysulfide (H2S n ) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO).
Q38229082Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
Q38258816Hydrogen sulfide and polysulfides as biological mediators.
Q36055721Hydrogen sulfide and polysulfides as signaling molecules
Q35015679Hydrogen sulfide as an oxygen sensor
Q51758188Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses.
Q48604182Hydrogen sulfide is essential for Schwann cell responses to peripheral nerve injury
Q37683393Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor κB (NF-κB) pathway
Q49874007Hydrogen sulfide, nitric oxide, and neurodegenerative disorders
Q38236845Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia.
Q38717958Hydrogen sulphide as a signalling molecule regulating physiopathological processes in gastrointestinal motility.
Q36123398Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain
Q92309718Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury
Q36837643Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.
Q89509540Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria
Q93273085Interaction between hydrogen sulfide, nitric oxide, and carbon monoxide pathways in the bovine isolated retina
Q26774063Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System
Q47914860International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
Q51063347Investigation of thiolysis of NBD amines for the development of H2S probes and evaluating the stability of NBD dyes.
Q38451870L-Cysteine metabolism and its nutritional implications
Q64107286L-Cysteine-Derived HS Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice
Q42368268Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis
Q30886573Mechanistic investigations reveal that dibromobimane extrudes sulfur from biological sulfhydryl sources other than hydrogen sulfide†Electronic supplementary information (ESI) available: Experimental details, pH stability data for BTE, NMR spectra. S
Q38545041Medicinal Chemistry: Insights into the Development of Novel H2S Donors.
Q38795213MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease
Q36480335Mini-review: diabetic renal complications, a potential stinky remedy
Q28386668Modes of physiologic H2S signaling in the brain and peripheral tissues
Q58557810Modulation of K channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides
Q46236962Mouse d-Amino-Acid Oxidase: Distribution and Physiological Substrates
Q26744013Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota
Q33559882New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS.
Q49982345Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine.
Q45016507Peptide-based hydrogen sulphide-releasing gels.
Q42015269Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S).
Q26740399Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator
Q38545013Physiological Roles of Hydrogen Sulfide and Polysulfides.
Q35596046Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons.
Q39093488Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells.
Q37737869Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels
Q51601346Potentiation of Hypoxic Pulmonary Vasoconstriction by Hydrogen Sulfide Precursors 3-Mercaptopyruvate and D-Cysteine Is Blocked by the Cystathionine γ Lyase Inhibitor Propargylglycine.
Q92877303Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms
Q37544124Production and physiological effects of hydrogen sulfide.
Q37016283Production of hydrogen sulfide from d-cysteine and its therapeutic potential.
Q90043563Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis
Q64100774Redox Pioneer: Professor Hideo Kimura
Q46245972Regulation of Aqueous Humor Dynamics by Hydrogen Sulfide: Potential Role in Glaucoma Pharmacotherapy
Q38709498Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception
Q35647095Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury.
Q47166058Role of Hydrogen Sulfide in Retinal Diseases
Q35103465Role of hydrogen sulfide in early blood-brain barrier disruption following transient focal cerebral ischemia.
Q41217057Role of hydrogen sulfide within the dorsal motor nucleus of the vagus in the control of gastric function in rats
Q55000550Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions.
Q46420694Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis
Q27024480Signaling molecules: hydrogen sulfide and polysulfide
Q34835381Sodium hydrosulfide prevents myocardial dysfunction through modulation of extracellular matrix accumulation and vascular density
Q55652298Specific downregulation of cystathionine β-synthase expression in the kidney during obesity.
Q91675920Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting
Q50644367Substrate-Specific Amino Acid Sensing Using a Molecular d/ l-Cysteine Probe for Comprehensive Stereochemical Analysis in Aqueous Solution.
Q28072907Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals
Q36384782Sulfur as a signaling nutrient through hydrogen sulfide
Q28083965The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential
Q38834599The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides
Q64903321The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease.
Q91807520The Effect of Hydrogen Sulfide on Different Parameters of Human Plasma in the Presence or Absence of Exogenous Reactive Oxygen Species
Q38671099The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and Signaling
Q28066719The Role of Hydrogen Sulfide in Renal System
Q49346285The dichotomous role of H2S in cancer cell biology? Déjà vu all over again
Q38967406The role of hydrogen sulfide in aging and age-related pathologies
Q90194790d-Cysteine-Induced Rapid Root Abscission in the Water Fern Azolla Pinnata: Implications for the Linkage between d-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses

Search more.